ALK5 inhibitor II
- CAS No.
- 446859-33-2
- Chemical Name:
- ALK5 inhibitor II
- Synonyms
- RepSox;E-616452;CS-204;E616452;SJN 2511;E 616452;RepSox, >=98%;RepSox(E-616452;ALK5 INHIBITOR I;RepSox (SJN 2511)
- CBNumber:
- CB3806232
- Molecular Formula:
- C17H13N5
- Molecular Weight:
- 287.32
- MDL Number:
- MFCD09037561
- MOL File:
- Mol file
- MSDS File:
- SDS
Melting point | 195 °C |
---|---|
Boiling point | 501.9±50.0 °C(Predicted) |
Density | 1.296±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO: >20mg/mL |
form | Yellow solid |
pka | 10.05±0.50(Predicted) |
color | Pale yellow |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
InChIKey | LBPKYPYHDKKRFS-UHFFFAOYSA-N |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319-H335 | |||||||||
Precautionary statements | P280-P305+P351+P338 | |||||||||
Hazard Codes | T | |||||||||
Risk Statements | 25 | |||||||||
Safety Statements | 45 | |||||||||
RIDADR | UN 2811 | |||||||||
WGK Germany | 3 | |||||||||
NFPA 704 |
|
ALK5 inhibitor II price More Price(34)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | R0158 | RepSox ≥98% (HPLC) | 446859-33-2 | 5mg | $134 | 2024-03-01 | Buy |
Sigma-Aldrich | R0158 | RepSox ≥98% (HPLC) | 446859-33-2 | 25mg | $565 | 2024-03-01 | Buy |
Sigma-Aldrich | 5.08158 | InSolution TGF-β RI Kinase Inhibitor II, RepSox - CAS 446859-33-2 - Calbiochem | 446859-33-2 | 5mg | $126 | 2024-03-01 | Buy |
TCI Chemical | R0224 | RepSox | 446859-33-2 | 5MG | $68 | 2024-03-01 | Buy |
TCI Chemical | R0224 | RepSox | 446859-33-2 | 25MG | $211 | 2024-03-01 | Buy |
ALK5 inhibitor II Chemical Properties,Uses,Production
Description
RepSox (446859-33-2) is a potent (IC50?ALK5 auto-P= 4 nM; IC50?TGF-β cellular assay = 23 nM) inhibitor of the TGF-β type I receptor (ALK5).1?RepSox can replace Sox2 in reprogramming adult cells into pluripotent stem cells via induction of Nanog transcription.2?It was able to convert astrocytes into neuronal cells as part of a small molecule cocktail (along with valproic acid and CHIR99021).3,4
Uses
Alk 5 Inhibitor II is a selective ATP competitive inhibitor of transforming growth factor-β (TGFβ). A potential drug for the treatment of fibrosis and cancer.
Uses
RepSox has been used as an inhibitor of autophosphorylation of the transforming growth factor β type I receptor kinase (ALK5). It has also been used as a basal media component for culturing human Pluripotent stem cells.
Definition
ChEBI: 1,5-naphthyridine, 2-[3-(6-methyl-2-pyridinyl)-1h-pyrazol-4-yl]- is a pyrazolopyridine.
Biochem/physiol Actions
RepSox Inhibits TGF-beta receptor signaling. Retroviral transduction of Sox2, Oct4, and Klf4 genes results in direct reprogramming of somatic cells into induced pluripotent stem cells (iPSCs).
storage
+4°C
References
1) Gellibert?et al. (2004),?Identification of 1,5-Naphthyridine Derivatives as a Novel Series of Potent and Selective TGF-β Type I Receptor Inhibitors; J. Med. Chem.?47?4494 2) Ichida?et al.?(2009),?A Small-molecule Inhibitor of TGF-β Signaling Replaces Sox2 in Reprogramming by Inducing Nanog; Cell Stem Cell?5?491 3) Cheng?et al.?(2015),?Direct Conversion of astrocytes into neuronal cells by a drug cocktail;?Cell Res.?25?1269 4) Cheng?et al.?(2014),?Generation of neural progenitor cells by chemical cocktails and hypoxia; Cell Res.?24?665
ALK5 inhibitor II Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9341 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
View Lastest Price from ALK5 inhibitor II manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2019-07-06 | 2-(3-(6-METHYLPYRIDIN-2-YL)-1H-PYRAZOL-4-YL)-1,5-NAPHTHYRIDINE
446859-33-2
|
US $1.00 / KG | 1KG | 98% | 1kg,5kg,100kg | Career Henan Chemical Co |
- 2-(3-(6-METHYLPYRIDIN-2-YL)-1H-PYRAZOL-4-YL)-1,5-NAPHTHYRIDINE
446859-33-2
- US $1.00 / KG
- 98%
- Career Henan Chemical Co