10-[(1-methyl-3-piperidyl)methyl]-10H-phenothiazine monohydrochloride
![10-[(1-methyl-3-piperidyl)methyl]-10H-phenothiazine monohydrochloride Structure](CAS/GIF/2975-36-2.gif)
- CAS No.
- 2975-36-2
- Chemical Name:
- 10-[(1-methyl-3-piperidyl)methyl]-10H-phenothiazine monohydrochloride
- Synonyms
- Mepazine hydrochloride;10-((1-methylpiperidin-3-yl)methyl)-10H-phenothiazine hydrochloride;10-[(1-methyl-3-piperidyl)methyl]-10H-phenothiazine monohydrochloride;10H-Phenothiazine, 10-[(1-methyl-3-piperidinyl)methyl]-,monohydrochloride
- CBNumber:
- CB3921722
- Molecular Formula:
- C19H23ClN2S
- Molecular Weight:
- 346.91732
- MDL Number:
- MOL File:
- 2975-36-2.mol
| Melting point | 180-181 °C |
|---|---|
| Boiling point | 180-183 °C(Press: 0.5 Torr) |
| storage temp. | Store at -20°C |
| solubility | DMSO: 50 mg/mL (144.13 mM) |
| FDA UNII | TIW15Q5R21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P264-P270-P301+P312-P501 |
10-[(1-methyl-3-piperidyl)methyl]-10H-phenothiazine monohydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 5.00500 | MALT1InhibitorII,MepazineHydrochloride-CAS2975-36-2-Calbiochem | 2975-36-2 | 25mg | $233 | 2023-01-07 | Buy |
| ChemScene | CS-0111531 | Mepazine(hydrochloride) 98.29% | 2975-36-2 | 100mg | $255 | 2021-12-16 | Buy |
| ChemScene | CS-0111531 | Mepazine(hydrochloride) 98.29% | 2975-36-2 | 250mg | $455 | 2021-12-16 | Buy |
| ChemScene | CS-0111531 | Mepazine(hydrochloride) 98.29% | 2975-36-2 | 25mg | $115 | 2021-12-16 | Buy |
| ChemScene | CS-0111531 | Mepazine(hydrochloride) 98.29% | 2975-36-2 | 50mg | $175 | 2021-12-16 | Buy |
10-[(1-methyl-3-piperidyl)methyl]-10H-phenothiazine monohydrochloride Chemical Properties,Uses,Production
Originator
Pacatal,Warner Lambert,US,1957
Manufacturing Process
A 500 cc flask equipped with a mechanical stirrer, reflux condenser and a soda-lime tube was filled with 230 cc of absolute xylene, 27.5 g of 1-methyl3-bromomethylpiperidine, 53.3 g of phenothiazine and 14.2 g of finely powdered sodium amide, and the solution was heated under reflux for 6 hours. After cooling water was added and the batch was extracted with ether. As the hydrochloric acid salt of the obtained phenothiazine derivative is difficultly soluble in water, the further processing was carried out by way of the acetate. The etheric solution was extracted several times in a separating funnel with dilute acetic acid. The combined aqueous extracts were basified, extracted with ether, dried with potassium carbonate and, after removal of the ether, distilled in vacuo.
Yield = 64%; boiling point 230°C to 235°C at 4 mm; melting point of
hydrochloride is 180°C to 181°C.
Therapeutic Function
Tranquilizer
10-[(1-methyl-3-piperidyl)methyl]-10H-phenothiazine monohydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou PBpharmaceutical R&D Co.,Ltd | 0519-83990708 | info@pbpharm.com | CHINA | 498 | 58 |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +86-19164747840 +86-13119157289 | 13119157289@163.com | China | 2971 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 4691 | 58 |
| Changzhou PBpharmaceutical R&D Co.,Ltd | 0519-83990708 | lxy2046@yeah.net | China | 480 | 55 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9824 | 58 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29796 | 68 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 18892239720 | psaitong@jm-bio.com | China | 12308 | 58 |
| Nanjing Qishi Biotechnology Co. Ltd. | 19822610310 | 3122922726@qq.com | China | 1346 | 58 |
| Chunchuang (Wuhan) Technology Co., Ltd | 15342225168 | yutianchun2007@126.com | China | 10005 | 58 |