antibiotic 1233A
- CAS No.
- 29066-42-0
- Chemical Name:
- antibiotic 1233A
- Synonyms
- 699;F-244;1233A;L-659699;Hymeglusin;Antibiotic F-244;antibiotic 1233A;(R,R)-HyMeglusin;(2E,4E,7R)-11-[(2R,3R)-3-Hydroxymethyl-4-oxooxetan-2-yl]-3,5,7-trimethyl-2,4-undecadienoic acid;(2E,4E,7R)-11-[(2R,3R)-3-(Hydroxymethyl)-4-oxo-2-oxetanyl]-3,5,7-trimethyl-2,4-undecadienoic acid
- CBNumber:
- CB41355000
- Molecular Formula:
- C18H28O5
- Molecular Weight:
- 324.41
- MDL Number:
- MOL File:
- 29066-42-0.mol
| Boiling point | 516.6±15.0 °C(Predicted) |
|---|---|
| Density | 1.101±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: soluble |
| form | powder |
| pka | 4.98±0.33(Predicted) |
| color | White |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
antibiotic 1233A price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0301 | Hymeglusin ≥98% (HPLC) | 29066-42-0 | 1mg | $377 | 2024-03-01 | Buy |
| Cayman Chemical | 11899 | Hymeglusin ≥95% | 29066-42-0 | 500μg | $124 | 2024-03-01 | Buy |
| Cayman Chemical | 11899 | Hymeglusin ≥95% | 29066-42-0 | 1mg | $211 | 2024-03-01 | Buy |
| Cayman Chemical | 11899 | Hymeglusin ≥95% | 29066-42-0 | 2.5mg | $496 | 2024-03-01 | Buy |
| TRC | H998033 | Hymeglusin | 29066-42-0 | 0.5mg | $580 | 2021-12-16 | Buy |
antibiotic 1233A Chemical Properties,Uses,Production
Description
Hymeglusin (29066-42-0) is an inhibitor of eukaryotic mevalonate biosynthesis via inhibition of HMG-CoA synthase, IC50=0.12 μM.1 Acts via covalent modification of the active site Cys129.1,2 Inhibits cholesterol biosynthesis in rats (45% at 25 mg/Kg).1 Also inhibits bacterial HMG-CoA synthase.3 Inhibits dengue virus replication.4
Uses
Hymeglusin is an irreversible HMG-CoA synthase inhibitor.
Definition
ChEBI: Hymeglusin is a long-chain fatty acid.
storage
+4°C
References
1) Greenspan et al. (1987), Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L-659,699; Proc. Natl. Acad. Sci. USA, 84 7488 2) Tomoda et al. (2004), Binding site for fungal beta-lactone hymeglusin on cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase; Biochem. Biophys. Acta, 1636 22 3) Skaff et al. (2012), Biochemical and structural basis for inhibition of Enterococcis faecalis hydroxymethylglutaryl-CoA synthase, mvaS, by hymeglusin; Biochemistry, 51 4713 4) Rothwell et al. (2009), Cholesterol biosynthesis modulation regulates dengue viral replication; Virology, 389 8
antibiotic 1233A Preparation Products And Raw materials
Raw materials
Preparation Products
antibiotic 1233A Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| Shanghai Maclean Biochemical Technology Co., LTD | 021-50706066 15221275939 | shenlinxing@macklin.cn | China | 29803 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9180 | 58 |