ChemicalBook >> CAS DataBase List >>[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]-

[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]-

[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]- structure

CAS No.: 945526-43-2

Chemical Name:: [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]-

Synonyms: ISCK03;ISCK 03; ISCK-03;C-KIT INHIBITOR II;Stem-Cell Factor/c-Kit Inhibitor;SteM-Cell Factor/c-Kit Inhibitor, ISCK03;T-Butylphenyl Imidazolylphenyl Sulfonamide;[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide;4-tert-butyl-N-(4-imidazol-1-ylphenyl)benzenesulfonamide;inhibit,SCFR,c-Kit,ISCK-03,CD117,Inhibitor,ISCK03,ISCK 03;N-(4-(1H-Imidazol-1-yl)phenyl)-4-(tert-butyl)benzenesulfonamide

CBNumber:: CB42098935

Molecular Formula:: C19H21N3O2S

Molecular Weight:: 355.45

MDL Number:: MFCD12031591

MOL File:: 945526-43-2.mol

Last updated:2023-06-08 09:02:15

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[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]- Properties

storage temp.	Sealed in dry,2-8°C
solubility	Soluble in ethanol or DMSO
form	solid
color	yellow
Sensitive	Light Sensitive
InChIKey	XQABBHBFHWHMKF-UHFFFAOYSA-N
FDA UNII	3028H7W568

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Risk Statements

Safety Statements

WGK Germany

NFPA 704

	0
2		0

[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]- price More Price(32)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	I6410	ISCK03 ≥98% (HPLC), solid	945526-43-2	5mg	$144	2024-03-01	Buy
Sigma-Aldrich	I6410	ISCK03 ≥98% (HPLC), solid	945526-43-2	25mg	$440	2024-03-01	Buy
Alfa Aesar	J65114	Stem-Cell Factor/c-Kit Inhibitor	945526-43-2	10mg	$139	2023-06-20	Buy
Alfa Aesar	J65114	Stem-Cell Factor/c-Kit Inhibitor	945526-43-2	50mg	$459	2021-12-16	Buy
Cayman Chemical	15781	ISCK03 ≥95%	945526-43-2	1mg	$34	2024-03-01	Buy

Product number	Packaging	Price	Buy
I6410	5mg	$144	Buy
I6410	25mg	$440	Buy
J65114	10mg	$139	Buy
J65114	50mg	$459	Buy
15781	1mg	$34	Buy

[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]- Chemical Properties,Uses,Production

Uses

Inhibits in vitro phosphorylation of c-Kit. Also inhibits SCF (stem cell factor)-induced c-kit phosphorylation in 501mel human melanoma cells

Biological Activity

isck03 is an inhibitor of scf-mediated c-kit activation.the signaling downstream of scf/c-kit plays a key role in the development of various mammalian cells, such as mast cells, melanocytes, primordial germ cells, and hematopoietic progenitor cells.

in vitro

previous study showed that the pretreatment of 501mel cells with isck03 could dose-dependently inhibit scf-induced c-kit phosphorylation. isck03 could also inhibit the phosphorylation of p44/42 erk mitogen-activated protein kinase that was known to be involved in scf/c-kit downstream signaling. however, isck03 was not able to inhibit hepatocyte growth factor-induced phosphorylation of p44/42 erk proteins [1].

in vivo

to determine the in vivo efficacy, isck03was orally administered to depilated c57bl/6 mice. results showed that the oral administration of isck03 could induce the dose-dependent depigmentation of newly regrown hair, and this was reversed with cessation of isck03 treatment. in addition, the topical application of isck03 could promote the depigmentation of uv-induced hyperpigmented spots on n brownish guinea pig skin. moreover, the fontana–masson staining analyses showed epidermal melanin was diminished in spots treated with isck03 [1].

References

[1] y. j. na, h. s. baek, s. m. ahn, et al. [4-t-butylphenyl]-n-(4-imidazol-1-yl phenyl)sulfonamide (isck03) inhibits scf/c-kit signaling in 501mel human melanoma cells and abolishes melanin production in mice and brownish guinea pigs. biochemical pharmacology 74(5), 780-786 (2007).

[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]- Suppliers

Global( 68)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32715	60
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5738	58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd	+86-86-22-87899925 +86-8618522618860	18522618860@163.com	China	694	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
Alfa Chemistry	+1-5166625404	Info@alfa-chemistry.com	United States	21317	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd	58
Zhejiang J&C Biological Technology Co.,Limited	58
Alfa Chemistry	58
InvivoChem	58
Nantong HI-FUTURE Biology Co., Ltd.	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58

View Lastest Price from [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]- manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-12-23	[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]- 945526-43-2	US $1.00 / g	1g	99.99%	200kg	Career Henan Chemical Co

[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]-
945526-43-2
US $1.00 / g
99.99%
Career Henan Chemical Co

945526-43-2([4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]-)Related Search:

3-Chloro-2-methylpropene

[4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide, Benzenesulfonamide, 4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl]- ISCK03 SteM-Cell Factor/c-Kit Inhibitor, ISCK03 [4-t-Butylphenyl]-N-(4-imidazol-1-yl phenyl)sulfonamide Benzenesulfonamide,4-(1,1-dimethylethyl)-N-[4-(1H-imidazol-1-yl)phenyl] ISCK 03; ISCK-03 4-tert-butyl-N-(4-imidazol-1-ylphenyl)benzenesulfonamide Stem-Cell Factor/c-Kit Inhibitor, ISCK03 - CAS 945526-43-2 - Calbiochem C-KIT INHIBITOR II Stem-Cell Factor/c-Kit Inhibitor inhibit,SCFR,c-Kit,ISCK-03,CD117,Inhibitor,ISCK03,ISCK 03 T-Butylphenyl Imidazolylphenyl Sulfonamide N-(4-(1H-Imidazol-1-yl)phenyl)-4-(tert-butyl)benzenesulfonamide 945526-43-2 API