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JNJ-26481585

JNJ-26481585 structure

CAS No.: 875320-29-9

Chemical Name:: JNJ-26481585

Synonyms: CS-1098;Quisinostat;JNJ-26481585;Quisinostat HClbase;JNJ26481585;JNJ 26481585;Quisinostat (JNJ-26481585);Quisinostat (JNJ-26481585) 2HCl;JNJ-26481585 JNJ26481585 Quisinostat;N1-(2-(1H-indol-3-yl)ethyl)-N4-(pyridin-4-yl)benzene-1,4-diaMine;N-Hydroxy-2-(4-((((1-methyl-1H-indol-3-yl)methyl)amino)-methyl)piperidin-1-yl)pyrimidine-5-car

CBNumber:: CB42500942

Molecular Formula:: C21H26N6O2

Molecular Weight:: 394.47

MDL Number:: MFCD17010272

MOL File:: 875320-29-9.mol

MSDS File:: SDS

Last updated:2023-05-21 10:59:17

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JNJ-26481585 Properties

Density	1.35
storage temp.	Store at -20°C
solubility	insoluble in H2O; insoluble in EtOH; ≥19.2 mg/mL in DMSO
form	Powder
FDA UNII	9BJ85K1J8S
NCI Drug Dictionary	quisinostat

JNJ-26481585 price More Price(29)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	14088	JNJ-26481585 ≥98%	875320-29-9	1mg	$71	2022-04-27	Buy
Cayman Chemical	14088	JNJ-26481585 ≥98%	875320-29-9	5mg	$177	2022-04-27	Buy
Cayman Chemical	14088	JNJ-26481585 ≥98%	875320-29-9	10mg	$317	2022-04-27	Buy
Cayman Chemical	14088	JNJ-26481585 ≥98%	875320-29-9	50mg	$703	2022-04-27	Buy
TRC	J211333	JNJ-26481585	875320-29-9	5mg	$275	2021-12-16	Buy

Product number	Packaging	Price	Buy
14088	1mg	$71	Buy
14088	5mg	$177	Buy
14088	10mg	$317	Buy
14088	50mg	$703	Buy
J211333	5mg	$275	Buy

JNJ-26481585 Chemical Properties,Uses,Production

Uses

JNJ-26481585 is an HDAC1, HDAC2, HDAC4, HDAC10, and HDAC11 inhibitor. Potent Histone deacetylase inhibitor.

Definition

ChEBI: N-hydroxy-2-[4-[[(1-methyl-3-indolyl)methylamino]methyl]-1-piperidinyl]-5-pyrimidinecarboxamide is a member of indoles.

Biological Activity

jnj-26481585 is a novel histone deacetylase (hdac) inhibitor that exerts a strong potency towards class i hdac (including hdac1, hdac2 and hdac3), with values of inhibition constant ic50 of 0.11, 0.33 and 4.8 nmol/l respectively, leading to strong anti-proliferative activities (ic50 ranging from 3.1 to 246 nmol/l) against a broad range of cancer cell lines including lung, breast, colon, prostate, brain and overian cancer cell lines. recent study results have shown that jnj-26481585 strongly induce the hdac1-suppressed p21waf1,cip1 promoter in vivo, histone h3 acetylation in tumor tissue and apoptosis in human colon cancer cell lines (both apc wild-type and mutant) in vitro.arts j, king p, mariën a, floren w, beliën a, janssen l, pilatte i, roux b, decrane l, gilissen r, hickson i, vreys v, cox e, bol k, talloen w, goris i, andries l, du jardin m, janicot m, page m, van emelen k, angibaud p. jnj-26481585, a novel "second-generation" oral histone deacetylase inhibitor, shows broad-spectrum preclinical antitumoral activity. clin cancer res. 2009;15(22):6841-6851

target

HDAC1

JNJ-26481585 Preparation Products And Raw materials

Raw materials

Preparation Products

JNJ-26481585 Suppliers

Global( 98)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	18232	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Hubei xin bonus chemical co. LTD	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
LEAP CHEM CO., LTD.	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Henan Fengda Chemical Co., Ltd	58
Amadis Chemical Company Limited	58

JNJ-26481585 Spectrum

JNJ-26481585(875320-29-9)¹HNMR

875320-29-9(JNJ-26481585)Related Search:

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JNJ-7706621 JNJ 63533054 N-(4-chloropyridin-3-yl)-4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)Methyl)piperazine-1-carboxaMide JNJ 31020028 JNJ-10229570

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Vorinostat (1S,4Z,7S,10S,11E,20R)-4-ethylidene-7,20-dipropan-2-yl-9-oxa-15,16-dit hia-3,6,18,21-tetrazabicyclo[8.7.6]tricos-11-ene-2,5,8,19,22-pentone CRA-02478

1of4

JNJ-26481585 N1-(2-(1H-indol-3-yl)ethyl)-N4-(pyridin-4-yl)benzene-1,4-diaMine N-Hydroxy-2-[4-[[[(1-methyl-1H-indol-3-yl)methyl]amino]methyl]-1-piperidinyl]-5-pyrimidinecarboxamide N-Hydroxy-2-(4-((((1-methyl-1H-indol-3-yl)methyl)amino)-methyl)piperidin-1-yl)pyrimidine-5-carbox N-Hydroxy-2-(4-((((1-Methyl-1H-indol-3-yl)Methyl)aMino)Methyl)piperidin-1-yl)pyriMidine-5-carboxaMide Quisinostat (JNJ-26481585) Quisinostat N-Hydroxy-2-(4-((((1-methyl-1H-indol-3-yl)methyl)amino)-methyl)piperidin-1-yl)pyrimidine-5-car Quisinostat (JNJ-26481585) 2HCl CS-1098 JNJ26481585;JNJ 26481585 N-hydroxy-2-[4-[[(1-methylindol-3-yl)methylamino]methyl]piperidin-1-yl]pyrimidine-5-carboxamide Quisinostat HClbase 5-Pyrimidinecarboxamide, N-hydroxy-2-[4-[[[(1-methyl-1H-indol-3-yl)methyl]amino]methyl]-1-piperidinyl]- JNJ-26481585 JNJ26481585 Quisinostat 875320-29-9 Inhibitors Inhibitor