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Chidamide

Chidamide structure

CAS No.: 743420-02-2

Chemical Name:: Chidamide

Synonyms: CS-1764;Chidamide;HBI-8000);HDAC-IN-7;Chidamide D4;Chidamide(CS055;chidamide analog;Chidamide impurity;Chidamide USP/EP/BP;Tucidinostat (Chidamide)

CBNumber:: CB42590631

Molecular Formula:: C22H19FN4O2

Molecular Weight:: 390.41

MDL Number:

MOL File:: 743420-02-2.mol

MSDS File:: SDS

Last updated:2023-05-18 11:31:21

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Chidamide Properties

Melting point	>145°C (dec.)
Boiling point	600.2±55.0 °C(Predicted)
Density	1.336±0.06 g/cm3(Predicted)
storage temp.	2-8°C(protect from light)
solubility	DMSO (Slightly), Methanol (Slightly, Sonicated)
form	Solid
pka	12.30±0.70(Predicted)
color	Off-White to Pale Beige
FDA UNII	462284YV3M

Chidamide price More Price(26)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	13686	Chidamide ≥98%	743420-02-2	1mg	$39	2021-12-16	Buy
Cayman Chemical	13686	Chidamide ≥98%	743420-02-2	5mg	$166	2021-12-16	Buy
Cayman Chemical	13686	Chidamide ≥98%	743420-02-2	10mg	$293	2021-12-16	Buy
Cayman Chemical	13686	Chidamide ≥98%	743420-02-2	25mg	$634	2021-12-16	Buy
Usbiological	445836	De-4-fluoro 5-Fluoro Chidamide	743420-02-2	25mg	$460	2021-12-16	Buy

Product number	Packaging	Price	Buy
13686	1mg	$39	Buy
13686	5mg	$166	Buy
13686	10mg	$293	Buy
13686	25mg	$634	Buy
445836	25mg	$460	Buy

Chidamide Chemical Properties,Uses,Production

Description

Chidamide (Epidaza®), a class I HDAC inhibitor, was discovered and developed by ChipScreen and approved by the CFDA in December 2014 for the treatment of recurrent of refractory peripheral T-cell lymphoma. Chidamide, also known as CS055 and HBI- 8000, is an orally bioavailable benzamide type inhibitor of HDAC isoenzymes class I 1–3, as well as class IIb 10, with potential antineoplastic activity. It selectively binds to and inhibits HDAC, leading to an increase in acetylation levels of histone protein H3.74 This agent also inhibits the expression of signaling kinases in the PI3K/ Akt and MAPK/Ras pathways and may result in cell cycle arrest and the induction of tumor cell apoptosis. Currently, phases I and II clinical trials are underway for the treatment of non-small cell lung cancer and for the treatment of breast cancer, respectively.

Uses

De-5-fluoro 4-Fluorochidamide is an analogue of Chidamide (CAS 743420-02-0), a hitsone deacetylase inhibitor (HDACI) that enhances gemcitabine (G305000) cytotoxicity in pancreatic cancer cells.

Synthesis

The scalable synthetic approach to chidamide very closely follows the discovery route. The sequence began with the condensation of commercial nicotinaldehyde (52) and malonic acid (53) in a mixture of pyridine and piperidine. Next, activation of acid 54 with N,N0-carbonyldiimidazole (CDI) and subsequent reaction with 4-aminomethyl benzoic acid (55) under basic conditions afforded amide 56 in 82% yield. Finally, activation of 56 with CDI prior to treatment with 4-fluorobenzene- 1,2-diamine (57) and subsequent treatment with TFA and THF yielded chidamide (VIII) in 38% overall yield from 52. However, no publication reported that mono-N-Boc-protected bis-aniline was used to approach Chidamide.

Synthesis_743420-02-2

References

[1] gong k, xie j, yi h, li w. cs055 (chidamide/hbi-8000), a novel histone deacetylase inhibitor, induces g1 arrest, ros-dependent apoptosisand differentiation in human leukaemia cells. biochem j. 2012 may 1;443(3):735-46.
[2] wang h1, guo y, fu m, liang x, etal. , antitumor activity of chidamide in hepatocellular carcinoma cell lines. mol med rep. 2012 jun;5(6):1503-8.

Chidamide synthesis

Synthesis of Chidamide from 3,4-Diaminofluorobenzene and (E)-4-((3-(pyridin-3-yl)acrylaMido)Methyl)benzoic acid

Chidamide Preparation Products And Raw materials

Raw materials

3,4-Diaminofluorobenzene (E)-4-((3-(pyridin-3-yl)acrylaMido)Methyl)benzoic acid

Preparation Products

Chidamide Suppliers

Global( 128)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
WinWin Chemical CO., Limited	+86-0577-64498589 +8615325081899	sales@win-winchemical.com	China	14151	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	28659	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Coresyn Pharmatech Co., Ltd.	+86-571-86626709 +86-18157142896	cbc@coresyn.com	China	9991	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Biochempartner	58
TargetMol Chemicals Inc.	58
WinWin Chemical CO., Limited	58
Dideu Industries Group Limited	58
InvivoChem	58
Coresyn Pharmatech Co., Ltd.	58
Nantong HI-FUTURE Biology Co., Ltd.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58

View Lastest Price from Chidamide manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-08-18	Chidamide USP/EP/BP 743420-02-2	US $1.10 / g	1g	99.9%	100 Tons min	Dideu Industries Group Limited
	2019-09-06	Chidamide 743420-02-2	US $1.00 / KG	1KG	98%	20kg	Career Henan Chemical Co

Chidamide USP/EP/BP
743420-02-2
US $1.10 / g
99.9%
Dideu Industries Group Limited

Chidamide
743420-02-2
US $1.00 / KG
98%
Career Henan Chemical Co

Chidamide Spectrum

Chidamide(743420-02-2)MS

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(E)-N-(2-amino-5-fluorophenyl)-4-((3-(pyridin-3-yl)acrylamido)methyl)benzamide Chidamide Chidamide (E)-N-(2-aMino-5-fluorophenyl)-4-((3-(pyridin-3-yl)acrylaMido)Methyl)benzaMide N-(2-Amino-5-fluorophenyl)-4-[[[1-oxo-3-(3-pyridinyl)-2-propenyl]amino]methyl]benzamide De-4-fluoro 5-Fluoro Chidamide CHIDAMIDE;(E)-N-(2-AMINO-5-FLUOROPHENYL)-4-((3-(PYRIDIN-3-YL)ACRYLAMIDO)METHYL)BENZAMIDE;(E)-N-(2-AMINO-5-FLUOROPHENYL)-4-((3-(PYRIDIN-3-YL)ACRYLAMIDO)METHYL)BENZAMIDE CHIDAMIDE;N-(2-AMINO-5-FLUOROPHENYL)-4-[[[1-OXO-3-(3-PYRIDINYL)-2-PROPENYL]AMINO]METHYL N-(2-Amino-5-fluorophenyl)-4-[[[1-oxo-3-(3-pyridinyl)-2-propenyl]amino]methyl Chidamide D4 Tucidinostat (Chidamide) chidamide analog Chidamide(CS055 CS-1764 HBI-8000) Chidamide,HBI-8000, CS-055, >96% Chidamide impurity HDAC-IN-7 Benzamide, N-(2-amino-5-fluorophenyl)-4-[[[1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]- Chidamide，HBI-8000， CS-055 Chidamide USP/EP/BP N-(2-Amino-5-fluorophenyl)-4-((3-(pyridin-3-yl)acrylamido)methyl)benzamide Benzamide,N-(2-amino-5-fluorophenyl)-[[[1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl] N - (2-amino-5-fluorophenyl) -4- ((3- (pyridin-3-yl) acrylamide) methyl) benzamide 743420-02-2 Inhibitors API