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Wortmannin-Rapamycin Conjugate

Wortmannin-Rapamycin Conjugate Structure
Wortmannin-Rapamycin Conjugate structure
CAS No.
1067892-47-0
Chemical Name:
Wortmannin-Rapamycin Conjugate
Synonyms
ATASUAOFUAOSAN-NVEIXTJJSA-N;Wortmannin-Rapamycin Conjugate;Rapamycin, 42-[8-[(1E,4S,4aR,5R,6aS,7S,9aR)-5-(acetyloxy)-1-[[[3-(dimethylamino)propyl]methylamino]methylene]-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydro-11-hydroxy-4-(methoxymethyl)-4a,6a-dimethyl-2,10-dioxocyclopenta[5,6]naphtho[1,2-c]pyran-7-yl] octanedioate]
CBNumber:
CB42592877
Molecular Formula:
C88H131N3O23
Molecular Weight:
1598.99
MDL Number:
MOL File:
1067892-47-0.mol
Last updated:2023-05-21 10:59:17
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Wortmannin-Rapamycin Conjugate Properties

storage temp. Store at -20°C
solubility DMF: 30 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml
form A crystalline solid

Wortmannin-Rapamycin Conjugate price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 13671 Wortmannin-Rapamycin Conjugate ≥98% 1067892-47-0 500μg $152 2024-03-01 Buy
Cayman Chemical 13671 Wortmannin-Rapamycin Conjugate ≥98% 1067892-47-0 1mg $288 2024-03-01 Buy
Cayman Chemical 13671 Wortmannin-Rapamycin Conjugate ≥98% 1067892-47-0 5mg $1204 2024-03-01 Buy
AK Scientific 1384EN 8-O-[(1S,3Ar,6E,9S,9aR,10R,11aS)-10-acetyloxy-6-[[3-(dimethylamino)propyl-methylamino]methylidene]-5-hydroxy-9-(methoxymethyl)-9a,11a-dimethyl-4,7-dioxo-2,3,3a,9,10,11-hexahydro-1H-indeno[4,5-h]isochromen-1-yl]1-O-[(1R,2R,4S)-4-[(2R)-2-[(1R,9S,12S,15R,16Z,18R,19R,21R,23S,24Z,26Z,28Z,30S,32S,35R)-1,18-dihydroxy-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-2,3,10,14,20-pentaoxo-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraen-12-yl]propyl]-2-methoxycyclohexyl]octanedioate 1067892-47-0 5mg $1439 2021-12-16 Buy
Product number Packaging Price Buy
13671 500μg $152 Buy
13671 1mg $288 Buy
13671 5mg $1204 Buy
1384EN 5mg $1439 Buy

Wortmannin-Rapamycin Conjugate Chemical Properties,Uses,Production

Description

Phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) act synergistically in promoting cancer. Wortmannin is a potent inhibitor of PI3K enzymes, while rapamycin blocks mTOR Complex 1 TORC1. Wortmannin-rapamycin conjugate consists of analogs of 17-hydroxy wortmannin and rapamycin conjugated via a prodrug linker. Hydrolysis of the prodrug linker in vivo releases the inhibitors. The wortmannin-rapamycin conjugate inhibits the growth of HT-29 colon tumors and A498 renal tumors in mice better than rapamycin alone. Also, the conjugate, when given in combination with the VEGF-blocker bevacizumab, produces substantial regression of larger A498 tumors. Finally, the wortmannin-rapamycin conjugate is tolerated better than an equivalent mixture of the inhibitors.

Wortmannin-Rapamycin Conjugate synthesis

1067892-18-5
4543-96-8
1067892-47-0
Synthesis of Wortmannin-Rapamycin Conjugate from Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy- and N,N,N'-TRIMETHYL-1,3-PROPANEDIAMINE

Wortmannin-Rapamycin Conjugate Preparation Products And Raw materials

Raw materials

Preparation Products

Wortmannin-Rapamycin Conjugate Suppliers

Global( 13)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences 16314854226 info@bocsci.com United States 9926 65
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8740 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.com China 24246 58
Supplier Advantage
BOC Sciences 65
Shanghai Hongye Biotechnology Co. Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58
Wortmannin-Rapamycin Conjugate ATASUAOFUAOSAN-NVEIXTJJSA-N Rapamycin, 42-[8-[(1E,4S,4aR,5R,6aS,7S,9aR)-5-(acetyloxy)-1-[[[3-(dimethylamino)propyl]methylamino]methylene]-1,2,4,4a,5,6,6a,7,8,9,9a,10-dodecahydro-11-hydroxy-4-(methoxymethyl)-4a,6a-dimethyl-2,10-dioxocyclopenta[5,6]naphtho[1,2-c]pyran-7-yl] octanedioate] 1067892-47-0 C88H131N3O23