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Atorvastatin Acetonide tert-Butyl Ester

CAS No.
125971-95-1
Chemical Name:
Atorvastatin Acetonide tert-Butyl Ester
Synonyms
tert R;tert-Butyl (4R,6R)-2;Atorvastatin USP RC I;Atorvastatin calcium-9;Atorvastatin condensate;Atorvastatin Impurity I;Atorvastatin EP IMpurity I;Atorvastatin Acetonide ter;Atorvastatin intermediate L1;DIPROTECTED ATORVASTATIN (L1)
CBNumber:
CB4317476
Molecular Formula:
C40H47FN2O5
Molecular Weight:
654.81
MDL Number:
MFCD04039904
MOL File:
125971-95-1.mol
MSDS File:
SDS
Last updated:2024-03-21 17:31:59

Atorvastatin Acetonide tert-Butyl Ester Properties

Melting point 144-148 °C(lit.)
Boiling point 678.0±55.0 °C(Predicted)
alpha 6.5 º (c=1, chloroform)
Density 1.14±0.1 g/cm3(Predicted)
storage temp. Refrigerator
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka 13.57±0.70(Predicted)
form Solid
color White
optical activity [α]20/D +6.5°, c = 1 in chloroform
InChIKey NPPZOMYSGNZDKY-ROJLCIKYSA-N
CAS DataBase Reference 125971-95-1(CAS DataBase Reference)
FDA UNII 0PTA8HGH1F

SAFETY

Risk and Safety Statements

Safety Statements  24/25
RIDADR  UN 2811 6.1 / PGII
WGK Germany  3
HS Code  29349990

Atorvastatin Acetonide tert-Butyl Ester price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1044593 Atorvastatin Related Compound I United States Pharmacopeia (USP) Reference Standard 125971-95-1 20mg $1300 2024-03-01 Buy
Sigma-Aldrich 570826 tert-Butyl (4R,6R)-6-[2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1-pyrrolyl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetate 97% 125971-95-1 1g $32 2023-06-20 Buy
TCI Chemical B3690 tert-Butyl (4R,6R)-2-[6-[2-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate >98.0%(HPLC)(N) 125971-95-1 1g $73 2024-03-01 Buy
TCI Chemical B3690 tert-Butyl (4R,6R)-2-[6-[2-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate >98.0%(HPLC)(N) 125971-95-1 5g $217 2024-03-01 Buy
Sigma-Aldrich PHR1874 Atorvastatin Related Compound I pharmaceutical secondary standard, certified reference material 125971-95-1 30mg $684 2024-03-01 Buy
Product number Packaging Price Buy
1044593 20mg $1300 Buy
570826 1g $32 Buy
B3690 1g $73 Buy
B3690 5g $217 Buy
PHR1874 30mg $684 Buy

Atorvastatin Acetonide tert-Butyl Ester Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

Atorvastatin Acetonide tert-Butyl Ester (Atorvastatin EP Impurity I) is an Atorvastatin intermediate.

125971-94-0
125971-95-1
Synthesis of Atorvastatin Acetonide tert-Butyl Ester from (4R,6R)-tert-Butyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate

Atorvastatin Acetonide tert-Butyl Ester Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 359)Suppliers
Supplier Tel Email Country ProdList Advantage
Jiangsu Yutian pharmaceutical Co.,Ltd.
+undefined-0518-86098006 +undefined19851887368 lvan.hui@jsytsw.com China 80 58
Hebei Mojin Biotechnology Co., Ltd
+8613288715578 sales@hbmojin.com China 12471 58
Hangzhou ICH Biofarm Co., Ltd
+undefined8613073685410 sales@ichemie.com China 985 58
hebei hongtan Biotechnology Co., Ltd
+86-86-1913198-3935 +8617331935328 sales03@chemcn.cn China 952 58
Capot Chemical Co.,Ltd.
571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886 info@dakenam.com China 15957 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21689 55
Shanghai Time Chemicals CO., Ltd.
+86-021-57951555 +8617317452075 jack.li@time-chemicals.com China 1807 55
career henan chemical co
+86-0371-86658258 sales@coreychem.com China 29914 58
Hubei Jusheng Technology Co.,Ltd.
18871490254 linda@hubeijusheng.com CHINA 28180 58

View Lastest Price from Atorvastatin Acetonide tert-Butyl Ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Atorvastatin Acetonide tert-Butyl Ester pictures 2024-05-14 Atorvastatin Acetonide tert-Butyl Ester
125971-95-1
US $50.00 / kg 1kg 99% 1000 hebei hongtan Biotechnology Co., Ltd
Atorvastatin Acetonide tert-Butyl Ester pictures 2024-02-20 Atorvastatin Acetonide tert-Butyl Ester
125971-95-1
US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
Atorvastatin Acetonide tert-Butyl Ester pictures 2024-01-14 Atorvastatin Acetonide tert-Butyl Ester
125971-95-1
US $0.00 / KG 1KG 99% 50000KG/month Hebei Mojin Biotechnology Co., Ltd
(4R-CIS)-1,1-DIMETHYLETHYL-6-[2-[2-(4-FLUOROPHENYL)-5-(1-ISOPROPYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROL-1-YL]ETHYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE (4R-CIS)-[1,1-DIMETHYLETHYL-6-[(2-FLUOROPHENYL)-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO) CARBONYL]-1H-PYRROL-1-YL]ETHYL]-2, 2-DIMETHYL-1, 3-DIOXANE-4-ACETATE (4R-CIS)-6-[2-[2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROL-1-YL]ETHYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETIC ACID, 1,1-DIMETHYLETHYL ESTER L-1(4R-Cis)-1,1-DiMethylethyl-6- 2- 2-(4-Fluorophenyl)-5-(1-Isopropyl)-3-Phenyl-4 (PhenylaMino)carbonyl -1H-pyrrol-1-yl Ethyl -2,2-DiMethyl-1,3-Dioxane-4-Acetate tert-butyl (4r,6r)-2-[[[6-(2-4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate tert-Butyl (4R,6R)-6-[2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1-pyrrolyl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetate tert-Butyl 2-[(4R,6R)-6-[2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl] (4R-cis)-1,1-dimethylethyl-6-[2-[2-(4-fluorophenyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetate Atorvastatin Calcium Impurity E 1,3-Dioxane-4-acetic acid, 6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R,6R)- L-1tert-butyl 2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate ert-Butyl (4R,6R)-2-[[[6-(2-4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate tert-Butyl 2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenyl-caramoyl)-1H-pyr (4R-CIS)-1,1-DIMETHYLETHYL-6-[2-[2-(4-FLUOROPHENYL)-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO) CARBONYL]-1H-PYRROL-1-yl]ETHYL]-2,2-DIMETHYL-1,3-DIOXANE-4-ACETATE (ATORVASTATINE CONDENSATION PRODUCT / L-1) tert-Butyl (4R,6R)-2 (4R-cis)-1,1-dimethylethyl-6-[2-[2-(4-fluorophenyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetate(L-1) tert-Butyl (4R,6R)-2-[6-[2-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbaMoyl)pyrrol-1-yl]ethyl]-2,2-diMethyl-1,3-dioxan-4-yl]acetate (4R,6R)-1,3-Dioxane-4-acetic acid, 6-[2-[2-(4-fluorophenyl)-5-(1-Methylethyl)-3-phenyl-4-[(phenylaMino)carbonyl]-1H-pyrrol-1-l]ethyl]- 2,2-diMethyl-1,1-diMethylethyl ester (4R-cis)-1,1-diMethylethyl-6-[2-[2-(4-fluorophenyl)-3-phenyl-4-[(phenylaMino)carbonyl]-1H-pyrro-1-yl]ethyl]-2,2-diMethyl-1,3-dioxane-4-acetate (4R-cis)-1,1-DiMethylethyl-6-[2-[2-(4-fluorophenyl)-5-(1-isoprophyl)-3-phenyl-4-[(phenylaMino)carbonyl]-1H-pyrrol-1-yl]-2,2-diMethyl-1,3-dioxane-4-acetate Atorvastatin Related Compound I (20 mg) (tert-Butyl 2-((4R,6R)-6-{2-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]ethyl}-2,2-dimethyl-1,3-dioxan-4-yl)acetate) (4R-CIS)-1,1-DIMETHYLETHYL-6-(2-(2-(4-FLUOROPHENYL)-5-(1-ISOPROPYL)-3-PHENYL-4-((PHENYLAMINO)CARBONYL)-1H-PYRROL-1-YL) Atorvastatin EP IMpurity I Atorvastatin calciuM interMediate tert-butyl 2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbaMoyl)-1H-pyrrol-1-yl)ethyl)-2,2-diMethyl-1,3-dioxan-4-yl)acetate Atorvastatin CalciuM InterMediate L1 tert-Butyl 2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenyl-caramoyl)-1H-pyrrol (4r,6r)-6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid 1,1-dimethylethyl ester Atorvastatin intermediate L1 (4R-Cis)-1,1-dimethylethyl-6-[2-[2-(4-fluoropheny) -5-(1-isopropyl)-3-phenyl-4-[(phenylamino) carbonyl]-1H-pyrrol-1-yl]ethy]-2,2-dimethyl-1, 3-dioxane-4-acetate (4R, 6R)-1,3-DIOXANE-4-ACETIC ACID, 6-(& Tert-Butyl (4R,6R)-2-[[[6-(2-4-Fluorophenyl)-5-Isopropyl-3-Phenyl-4-(Phenylcarbamoyl)Pyrrol-1Yl]Ethyl]-2,2-
Di-Methyl-1,3-Dioxan-4-Yl]Acetate
(4R-Cis)-1,1-dimethylethyl-6-[2-2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4- Atorvastatin Acetonide tert-Butyl Ester tert-Butyl (4R,6R)-2-[[[6-(2-4-fluorop... DIPROTECTED ATORVASTATIN (L1) (4R,6R)-6-[2-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid t-butyl ester Atorvastatin Impurity 30(Atorvastatin EP Impurity I) Atorvastatin USP RC I 2-[(4R,6R)-6-[2-[4-[anilino(oxo)methyl]-2-(4-fluorophenyl)-3-phenyl-5-propan-2-yl-1-pyrrolyl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetic acid tert-butyl ester Atorvastatin impurity 12/Atorvastatin EP Impurity I/Atorvastatin Acetonide tert-Butyl Ester/(4R,6R)-6-[2-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-Dimethylethy Atorvastatin calcium-9 tert-Butyl 2-[(4R,6R)-6-[2-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate tert-Butyl (4R,6R)-2-[6-[2-[2-(4-Fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate > tert R Atorvastatin impurity 12/Atorvastatin EP Impurity I/Atorvastatin Acetonide tert-Butyl Ester/(4R,6R)-6-[2-[2-(4-Fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-Dimethylethyl Ester tert-Butyl (4R,6R)-2-[[[6-(2-4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)pyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate [L-1] Atorvastatin Acetonide t-Butyl Ester Atorvastatin Acetonide tert-Butyl Ester(L1) Atorvastatin acetylacetone tert-butyl ester Atorvastatin imp I ( acetonide tert butyl ester) Atorvastatin condensate "Atorvastatin condensate" Atorvastatin calcium Impurities (V)“ USP Atorvastatin Related Compound I Atorvastatin EP Impurity I/ Atorvastatin Related Compound I (Atorvastatin Acetonide t-Butyl Ester) Atorvastatin Impurity I (4R-CIS)-1,1-DIMETHYLETHYL-6-[2-[2-(4-FLUOROPHENYL)-5-(1-MET... ATV imp I ( acetonide tert butyl ester)