(E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide(WXC09160)
- CAS No.
- 1613465-33-0
- Chemical Name:
- (E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide(WXC09160)
- Synonyms
- ML-336;2-[(1,4-Dimethylpiperazin-2-ylidene)amino]-5-nitro-N-phenylbenzamide;(E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide;Benzamide, 2-[(E)-(1,4-dimethyl-2-piperazinylidene)amino]-5-nitro-N-phenyl-;B355252 2-[(1,4-Dimethylpiperazin-2-ylidene) amino]-5-nitro-N-phenylbenzamide;(E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide(WXC09160);ML 336,VEEV V3526 CPE,inhibit,VEEV TC-83 CPE,ML-336,ML336,Virus Protease,VEEV,VEEV Wild Type CPE,venezuelan equine encephalitis virus,Inhibitor
- CBNumber:
- CB43910320
- Molecular Formula:
- C19H21N5O3
- Molecular Weight:
- 367.4
- MDL Number:
- MFCD28160682
- MOL File:
- 1613465-33-0.mol
(E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide(WXC09160) price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 9001920 | ML-336 ≥98% | 1613465-33-0 | 1mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 9001920 | ML-336 ≥98% | 1613465-33-0 | 5mg | $227 | 2024-03-01 | Buy |
| Cayman Chemical | 9001920 | ML-336 ≥98% | 1613465-33-0 | 10mg | $333 | 2024-03-01 | Buy |
| Cayman Chemical | 9001920 | ML-336 ≥98% | 1613465-33-0 | 25mg | $770 | 2024-03-01 | Buy |
| ApexBio Technology | C3581 | ML-336 | 1613465-33-0 | 25mg | $879 | 2021-12-16 | Buy |
(E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide(WXC09160) Chemical Properties,Uses,Production
Biological Activity
ml-336 is an inhibitor for veev-induced cytopathic effect.alphaviruses like venezuelan equine encephalitis virus (veev) are positive-sense, enveloped, single stranded rna viruses that are widely geographically distributed. veevs are found to be arthropod-borne viruses that are known to cause arthritis, encephalitis, rash, as well as death in humans.
in vitro
ml336 was identified as a first-in-class probe that inhibited a veev-induced cytopathic effect in three strains of the virus, which were v3526, tc-83, and trinidad donkey, in the low nanomolar range without having cytotoxicity (> 50 μm, selectivity index > 1500). in addition, ml336 could reduce viral titer (more than 7.2 log) dramatically below a 1 μm drug concentration. furthermore, ml336 showed a favorable in vitro pk profile that included moderate blood-brain barrier permeability. more importantly, ml336 seemed to be able to target the veev [1].
IC 50
32, 20, and 41 nm for tc-83, v3526, and trinidad donkey strains, respectively.
References
[1] chung d et al. ml336: development of quinazolinone-based inhibitors against venezuelan equine encephalitis virus (veev). probe reports from the nih molecular libraries program. bethesda (md): national center for biotechnology information (us); 2010-2012 dec 17.
(E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide(WXC09160) Preparation Products And Raw materials
Raw materials
Preparation Products
(E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-N-phenylbenzamide(WXC09160) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Labnetwork lnc. | +86-27-50766799 +8618062016861 | contact@labnetwork.com | China | 19994 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
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| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 4691 | 58 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8015 | 62 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2985 | 58 |
| Wuxi AppTec | 022-59987777 13552403979 | jia_guoqiang@wuxiapptec.com | China | 22346 | 58 |