1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide
- CAS No.
- 1892-57-5
- Chemical Name:
- 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide
- Synonyms
- EDCI;EDAC;1-ETHYL-3-(3-DIMETHYLAMINOPROPYL) CARBODIIMIDE;WSCI;WSCD;N1-((EthyliMino)Methylene)-N3,N3-diMethylpropane-1,3-diaMine;1-(3-Dimethylaminopropyl)-3-;N-(3-DIMETHYLAMINOPROPYL)-N'-ETHYLCARBODIIMIDE;({[3-(dimethylamino)propyl]imino}methylidene)(ethyl)amine;WSC【Dotite】
- CBNumber:
- CB4403030
- Molecular Formula:
- C8H17N3
- Molecular Weight:
- 155.24
- MDL Number:
- MFCD00044916
- MOL File:
- 1892-57-5.mol
- MSDS File:
- SDS
| Boiling point | 66-68°C/1mm |
|---|---|
| Density | 0.877 g/mL at 20 °C (lit.) |
| refractive index |
n |
| Flash point | 66-68°C/1mm |
| storage temp. | -20°C |
| solubility | Chloroform |
| pka | 9.52±0.28(Predicted) |
| form | Liquid |
| Specific Gravity | 0.885 |
| color | Colorless to slightly yellow |
| Water Solubility | Soluble in water. |
| Sensitive | Air Sensitive |
| BRN | 507429 |
| InChIKey | LMDZBCPBFSXMTL-UHFFFAOYSA-N |
| CAS DataBase Reference | 1892-57-5(CAS DataBase Reference) |
| FDA UNII | RJ5OZG6I4A |
| NIST Chemistry Reference | 1,3-Propanediamine, n'-(ethylcarbonimidoyl)-n,n-dimethyl-(1892-57-5) |
| EPA Substance Registry System | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl- (1892-57-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS06,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H311-H315-H317-H373-H410 | |||||||||
| Precautionary statements | P260-P273-P280-P301+P312-P302+P352+P312-P314 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34 | |||||||||
| Safety Statements | 26-36/37/39-45 | |||||||||
| RIDADR | UN 2735 8/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 1-3-10 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29252900 | |||||||||
| NFPA 704 |
|
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 39391 | N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide ≥97.0% (T) | 1892-57-5 | 10ml | $185 | 2024-03-01 | Buy |
| Sigma-Aldrich | 39391 | N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide ≥97.0% (T) | 1892-57-5 | 50ml | $798 | 2024-03-01 | Buy |
| TCI Chemical | D4029 | 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide >98.0%(GC)(T) | 1892-57-5 | 5g | $80 | 2024-03-01 | Buy |
| TCI Chemical | D4029 | 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide >98.0%(GC)(T) | 1892-57-5 | 25g | $240 | 2024-03-01 | Buy |
| Alfa Aesar | B25057 | 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide, 98% | 1892-57-5 | 5g | $106 | 2024-03-01 | Buy |
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Chemical Properties,Uses,Production
Description
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide is a water-soluble carbodiimide available as hydrochloride salt. This compound is a carboxyl- and amine-reactive crosslinker that is water soluble and can activate carboxyl residues for their reaction with primary amines to form O-acylisourea as a reaction intermediate, which reacts with amide bonds to release isourea as a by-product. It can crosslink the carboxy-group of glutamate and aspartate to the side-chain primary amine of lysine and the amino group at the N-terminus. The crosslinker readily reacts at a pH range of 4.5–7.2 and only crosslinks the residues within their van der Waals distance. 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide is also widely used in fabricating different nanosystems implemented in drug/protein delivery systems. It is mainly used for surface crosslinking/immobilization of drugs to increase stability against environmental changes, such as pH or temperature[1-2].
Chemical Properties
Clear light yellow liquid
Uses
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide is used as a carboxyl activating agent and activate phosphate groups in phospho mono and di esters. It is used in peptide synthesis, 3'-amino-3'-deoxyadenosine-5'-di- and triphosphates and in the preparation of antibodies like immunoconjugates. It plays a vital role for immobilization of large biomolecules in association with N-hydroxysuccinimide. It is also used in the acylation of phosphoranes.
General Description
N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide is commonly used in combination with N-hydroxysuccinimide (NHS) in carbodiimide coupling reaction to activate carboxyl group for coupling with amines to form amides.
Synthesis
The production method of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide is to react with N, N'-dimethylpropanediamine and carbon disulfide as raw materials to prepare N, N'- Dimethylpropylthiourea. Then it is oxidized with ethyl chloroformate to obtain N, N'-dimethylpropyl isothiocyanate, which is then reacted with ethylamine and oxidized with sodium hypochlorite to obtain the product 1-(3-dimethylaminopropyl)-3- Ethylcarbodiimide.
References
[1] Manjula ;Mummadisetti et al.“Chapter Five-An approach to nearest neighbor analysis of pigment-protein complexes using chemical cross-linking in combination with mass spectrometry.” Methods in enzymology" Methods in Enzymology, 680 (2023) 139-162.
[2] Dmour, Isra and M. Taha. “Natural and semisynthetic polymers in pharmaceutical nanotechnology.”Organic Materials as Smart Nanocarriers for Drug Delivery (2018) 35-100.
1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Z&T Chemical Co., Ltd | +86-21-33561011 13818804961 | Sales@ztchemical.com.cn | China | 402 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12471 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 6000 | 58 |
| Ouhuang Engineering Materials (Hubei) Co., Ltd | +8617702722807 | admin@hbouhuang.com | China | 3001 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15956 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8822 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5909 | 58 |
View Lastest Price from 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-25 | 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide
1892-57-5
|
US $30.00 / kg | 1kg | 99.7% | 200000kg | Ouhuang Engineering Materials (Hubei) Co., Ltd | |
 |
2023-10-26 | 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide
1892-57-5
|
US $30.00-9.00 / kg | 1kg | 0.99 | 10 tons | Hebei Yanxi Chemical Co., Ltd. | |
 |
2023-06-28 | 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide
1892-57-5
|
US $0.00 / KG | 1KG | 99% | 50000KG/month | Hebei Mojin Biotechnology Co., Ltd |
-
- 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide
1892-57-5
- US $30.00 / kg
- 99.7%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
-
- 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide
1892-57-5
- US $30.00-9.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
-
- 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide
1892-57-5
- US $0.00 / KG
- 99%
- Hebei Mojin Biotechnology Co., Ltd