Azanidazole
- CAS No.
- 62973-76-6
- Chemical Name:
- Azanidazole
- Synonyms
- Azanidazole;2-Pyrimidinamine, 4-[(1E)-2-(1-methyl-5-nitro-1H-imidazol-2-yl)ethenyl]-
- CBNumber:
- CB4875521
- Molecular Formula:
- C10H10N6O2
- Molecular Weight:
- 246.23
- MDL Number:
- MOL File:
- 62973-76-6.mol
| Melting point | 232-235° |
|---|---|
| Boiling point | 389.22°C (rough estimate) |
| Density | 1.3200 (rough estimate) |
| refractive index | 1.7000 (estimate) |
| FDA UNII | YP2Y0DRX4S |
| ATC code | G01AF13,P01AB04 |
SAFETY
Risk and Safety Statements
| Toxicity | LD50 in mice, rats (mg/kg): 5100, 7600 orally; 590, 860 i.p. (Tammiso) |
|---|
Azanidazole Chemical Properties,Uses,Production
Originator
Triclose,Ist. Chemioter.,Italy,1977
Uses
Antiprotozoal.
Definition
ChEBI: Azanidazole is a member of imidazoles and a C-nitro compound.
Manufacturing Process
Into a mixture of 1.6 g of 2-amino-4-methylpyrimidine with 10 ml of glacial acetic acid is slowly added 2.13 g of concentrated sulfuric acid. A mixture of 2.4 g of 2-formyl-1-methyl-5-nitroimidazole in 20 ml of glacial acetic acid is slowly added to the mixture of the pyrimidine under stirring. The reaction mixture is maintained at a temperature of about 55°C for 4 hours. The resultant mixture is then diluted with 200 ml of distilled water and neutralized with a saturated aqueous solution of sodium bicarbonate. A brownish-yellow precipitate (MP 232° to 235°C) is formed and recovered. The product is analyzed by infrared spectroscopy and is found to conform to 2-amino-4-[2- (1-methyl-5-nitro-2-imidazolyl)vinyl]pyrimidine.
Therapeutic Function
Antiprotozoal, Antibacterial
Safety Profile
Moderately toxic byintraperitoneal route. Mildly toxic by ingestion.Experimental reproductive effects. Mutation datareported. When heated to decomposition it emits toxicfumes of NOx.
Azanidazole Preparation Products And Raw materials
Azanidazole Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52861 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 50000 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | 029-81124267 15229202216 | 1073@dideu.com | China | 10011 | 58 |
| Supplier | Advantage |
|---|---|
| Dayang Chem (Hangzhou) Co.,Ltd. | 58 |
| GIHI CHEMICALS CO.,LIMITED | 58 |
| Shaanxi Dideu Medichem Co. Ltd | 58 |