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INDEX NAME NOT YET ASSIGNED

INDEX NAME NOT YET ASSIGNED Structure
INDEX NAME NOT YET ASSIGNED structure
CAS No.
2738688-57-6
Chemical Name:
INDEX NAME NOT YET ASSIGNED
Synonyms
CBP/p300-IN-12
CBNumber:
CB511614839
Molecular Formula:
C33H29F4N5O6
Molecular Weight:
667.61
MDL Number:
MOL File:
Mol file
Last updated:2023-07-14 17:28:39
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INDEX NAME NOT YET ASSIGNED Properties

Density 1.46±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 250 mg/mL (374.47 mM; Need ultrasonic)
pka 13.36±0.70(Predicted)

INDEX NAME NOT YET ASSIGNED Chemical Properties,Uses,Production

Biological Activity

CBP/p300-IN-12 is a potent and selective covalent histone acetyltransferases p300 (IC50 of 166 nM) and CBP inhibitor. CBP/p300-IN-12 decreases the levels of H3K27Ac of PC-3 cells (EC50 of 37 nM). CBP/p300-IN-12 forms a covalent adduct with C1450[1]. CBP/p300-IN-12 (Compound 2) shows antiproliferative effect against androgen receptor (AR)-positive LnCaP-FGC cells (EC50 of 87 nM), while displaying significantly less activity in the AR-negative cell line DU-145 (EC50 of 1.37 μM).

References

[1]. Anthony Mastracchio, et al. Discovery of a Potent and Selective Covalent p300/CBP Inhibitor. ACS Med Chem Lett. 2021 Apr 5;12(5):726-731.

INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials

Raw materials

Preparation Products

INDEX NAME NOT YET ASSIGNED Suppliers

Global( 1)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
Supplier Advantage
Aladdin Scientific 		58
CBP/p300-IN-12 2738688-57-6 C33H29F4N5O6