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ChemicalBook >> CAS DataBase List >>1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid

1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid

1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid Structure
1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid structure
CAS No.
849217-48-7
Chemical Name:
1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid
Synonyms
1-((4-FL;Cabozantinib impurities4;InterMediate of Cabozantinib;Intermediate2 of Cabozantinib;FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID;1-(4-FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID;1-(5-FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID;((4-fluorophenyl)carbamoyl)cyclopropane carboxylic acid;1-(4- fluorophenyl formamido) cyclopropanecarboxylic acid;1-{[(4-fluorophenyl)aMino]carbonyl}cyclopropanecarboxylic acid
CBNumber:
CB52460100
Molecular Formula:
C11H10FNO3
Molecular Weight:
223.2
MDL Number:
MFCD11226313
MOL File:
849217-48-7.mol
Last updated:2024-05-15 10:59:15
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1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid Properties

Melting point 173.0 to 177.0 °C
Boiling point 475.2±30.0 °C(Predicted)
Density 1.521
storage temp. Sealed in dry,Room Temperature
solubility soluble in Methanol
form powder to crystal
pka 3.48±0.20(Predicted)
color White to Almost white
InChI InChI=1S/C11H10FNO3/c12-7-1-3-8(4-2-7)13-9(14)11(5-6-11)10(15)16/h1-4H,5-6H2,(H,13,14)(H,15,16)
InChIKey PFMAFXYUHZDKPY-UHFFFAOYSA-N
SMILES C1(C(NC2=CC=C(F)C=C2)=O)(C(O)=O)CC1
FDA UNII 8P43N3DM5Y

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315+H320
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
HS Code  2924.29.9500
NFPA 704
0
2 0

1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid price More Price(23)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical F1083 1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic Acid >98.0%(HPLC)(T) 849217-48-7 1g $105 2024-03-01 Buy
TCI Chemical F1083 1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic Acid >98.0%(HPLC)(T) 849217-48-7 5g $318 2024-03-01 Buy
TRC F632340 1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic Acid 849217-48-7 10mg $45 2021-12-16 Buy
AK Scientific W8765 1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic Acid 849217-48-7 1g $27 2021-12-16 Buy
AK Scientific W8765 1-[(4-Fluorophenyl)carbamoyl]cyclopropanecarboxylic Acid 849217-48-7 25g $321 2021-12-16 Buy
Product number Packaging Price Buy
F1083 1g $105 Buy
F1083 5g $318 Buy
F632340 10mg $45 Buy
W8765 1g $27 Buy
W8765 25g $321 Buy

1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid Chemical Properties,Uses,Production

Chemical Properties

White powdery substance.

Uses

1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid is a useful research chemical that can be used as a cabozantinib intermediate.

Synthesis

Cyclopropyl-1,1-dicarboxylic acid(10 g, 77 mmol) in THF (100 mL) was cooled in an ice-water bath, and Triethylamine (8.0 g, 79 mmol) was added dropwise. The temperature of the ice bath during the dropping process is controlled below 10 degrees. The resulting solution was stirred for 30 minutes, and then thionyl chloride (SOCl2, 9.0 g, 76 mmol). Then, dropwise, 4-fluoroaniline (9.0 mL) of THF (30 mL) was added. The ice bath temperature during the whole dripping process is controlled below 10 degrees. The stirring continued for 4 hours, and the reaction was warmed to room temperature. The reaction was diluted with 200 mL of EtOAc And then washed with aqueous NaOH (1.0 M, 50 mL), water (40 mL), and saturated brine (40 mL). The resulting organic solution was dried over Na2SO4, suction filtered, and evaporated to ~ 30 mL. To the resulting viscous liquid was added heptane (200 mL), and a lot of flaky solid precipitated. Filtration and drying gave 1-((4-Fluorophenyl)carbamoyl) cyclopropane carboxylic acid (15.8 g, 93 percent).

1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid synthesis

372-19-0
598-10-7
849217-48-7
Synthesis of 1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid from 3-Fluoroaniline and 1,1-Cyclopropanedicarboxylic acid

1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid Preparation Products And Raw materials

Raw materials

1,1-Cyclopropanedicarbonyl dichloride (9CI) Cyclopropanecarboxylic acid, 1-(chlorocarbonyl)- (9CI) METHYL 1-[(4-FLUOROPHENYL)CARBAMOYL]CYCLOPROPANECARBOXYLATE ethyl 1-(4-fluorophenylcarbaMoyl)cyclopropanecarboxylate 1-(ethoxycarbonyl)cyclopropanecarboxylic acid
1,1-Cyclopropanedicarboxylic acid monomethyl ester 1,1-Cyclopropanedicarboxylic acid dimethyl ester 3-Fluoroaniline 1,1-Cyclopropanedicarboxylic acid 4-Fluoroaniline
Diethyl 1,1-cyclopropanedicarboxylate

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Preparation Products

Cabozantinib

1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid Suppliers

Global( 243)Suppliers
Supplier Tel Email Country ProdList Advantage
Huanfu Industrial Co.，（Shanghai）Ltd.
+86-18001856580 +86-18001856580 2415195517@qq.com China 43 58
Hebei Longbang Technology Co., LTD
+86-18032476855 +86-18032476855 admin@hblongbang.com China 930 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 18214 58
Hebei Saisier Technology Co., LTD 		+86-18400010335 +86-18034520335 admin@hbsaisier.cn China 945 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15954 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32715 60
Shandonghaohong biotechnology Co.,ltd. 		0635-6175299 13961496334 sale@inyelchem.com CHINA 44 55
Anqing Chico Pharmaceutical Co., Ltd. 		15380796838 chloewu@chicopharm.cn CHINA 341 58
Supplier Advantage
Huanfu Industrial Co.，（Shanghai）Ltd.
58
Hebei Longbang Technology Co., LTD
58
Henan Fengda Chemical Co., Ltd 		58
Hebei Saisier Technology Co., LTD 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
ATK CHEMICAL COMPANY LIMITED 		60
Shandonghaohong biotechnology Co.,ltd. 		55
Anqing Chico Pharmaceutical Co., Ltd. 		58

View Lastest Price from 1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid pictures 2024-05-09 1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid
849217-48-7
 US $0.00-0.00 / kg 1kg 98% 1 ton Nanjing Fred Technology Co., Ltd
CYCLOPROPANECARBOXYLIC ACID pictures 2024-05-08 CYCLOPROPANECARBOXYLIC ACID
849217-48-7
 US $6.00 / KG 1KG 99% 20TONS Hebei Longbang Technology Co., Ltd
1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid pictures 2024-04-18 1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid
849217-48-7
 US $6.00 / KG 1KG 99% 2000KG/MONTH Hebei Saisier Technology Co., LTD

849217-48-7(1-((4-Fluorophenyl)carbamoyl)cyclopropanecarboxylic acid)Related Search:

2-Aminocyclohexanone 4-Aminodiphenylamine 4-Benzothiazolamine (9CI) 4-((6,7-Dimethoxyquinolin-4-yl)oxy)aniline Cabozantinib Malate
4-Aminoveratrole Cabozantinib Impurity 5 N-(4-fluorophenyl)-N-(4-hydroxyphenyl)cyclopropane-1,1-dicarboxamide 4-chloro-6,7-dimethoxyquinoline Cabozantinib Impurity EXA
Cabozantinib impurity DX2 Cyclopropanecarboxylic acid, 1-[[[4-[[7-methoxy-6-(sulfooxy)-4-quinolinyl]oxy]phenyl]amino]carbonyl]- 1,1-Cyclopropanedicarboxamide,N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-phenyl- Quinoline, 6,7-dimethoxy-4-(4-nitrophenoxy)- Cyclopropanecarboxylic acid, 1-[(phenylaMino)carbonyl]-
1,1-Cyclopropanedicarboxamide, N,N'-bis[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]- Cabozantinib impurity 1DYH Cyclopropanecarboxylic acid, 1-[[(2-fluorophenyl)amino]carbonyl]-

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1-(4-FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID Cyclopropanecarboxylic acid, 1-[[(4-fluorophenyl)aMino]carbonyl]- 1-{[(4-fluorophenyl)aMino]carbonyl}cyclopropanecarboxylic acid InterMediate of Cabozantinib FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID ((4-fluorophenyl)carbamoyl)cyclopropane carboxylic acid 1-(5-FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID Intermediate2 of Cabozantinib 1-(4-FLUOROPHENYLCARBAMOYL)CYCLOPROPANECARBOXYLIC ACID(849217-48-7) 1-((4-FL 1-(4- fluorophenyl formamido) cyclopropanecarboxylic acid Cabozantinib impurities4 849217-48-7 849214-48-7 849217-48-7