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CAY10607

CAY10607 Structure
CAY10607 structure
CAS No.
1012788-65-6
Chemical Name:
CAY10607
Synonyms
CAY10607;CAY10607 Exclusive;Benzisoxazole Hsp90 Inhibitor;1,3-Benzenediol, 4-chloro-6-[5-[[2-(4-morpholinyl)ethyl]amino]-1,2-benzisoxazol-3-yl]-
CBNumber:
CB52590441
Molecular Formula:
C19H20ClN3O4
Molecular Weight:
389.83
MDL Number:
MFCD18382085
MOL File:
1012788-65-6.mol
Last updated:2023-05-21 10:59:17
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CAY10607 Properties

storage temp. Store at -20°C
solubility DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 25 mg/ml; Ethanol:PBS (pH 7.2) (1:10): 0.1 mg/ml
form A crystalline solid

CAY10607 price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10012694 Benzisoxazole Hsp90 Inhibitor ≥98% 1012788-65-6 1mg $120 2024-03-01 Buy
Cayman Chemical 10012694 Benzisoxazole Hsp90 Inhibitor ≥98% 1012788-65-6 5mg $537 2024-03-01 Buy
Cayman Chemical 10012694 Benzisoxazole Hsp90 Inhibitor ≥98% 1012788-65-6 10mg $952 2024-03-01 Buy
TRC B201968 BenzisoxazoleHsp90Inhibitor 1012788-65-6 2.5mg $340 2021-12-16 Buy
AK Scientific 1409AH 4-Chloro-6-(5-((2-(4-morpholinyl)ethyl)amino)-1,2-benzisoxazol-3-yl)-1,3-benzenediol 1012788-65-6 5mg $695 2021-12-16 Buy
Product number Packaging Price Buy
10012694 1mg $120 Buy
10012694 5mg $537 Buy
10012694 10mg $952 Buy
B201968 2.5mg $340 Buy
1409AH 5mg $695 Buy

CAY10607 Chemical Properties,Uses,Production

Description

Benzisoxazole Hsp90 inhibitor is an inhibitor of heat shock protein 90 (Hsp90; IC50 = 30 nM in a fluorescence polarization assay). It is selective for Hsp90 over a panel of kinases (IC50s = >20 μM). Benzisoxazole Hsp90 inhibitor inhibits the proliferation of HCT116, SK-BR-3, LNCaP, DU145, and H157 cancer cells (IC50s = 0.28, 0.37, 0.17, 0.29, and 0.23 μM, respectively). It also induces degradation of the Hsp90 targets HER2 and the androgen receptor in SK-BR-3 and LNCaP cells, respectively, with an IC50 value of 0.33 μM for both.

Uses

Benzisoxazole Hsp90 Inhibitor is an inhibitor that binds to the N-terminal domain of Hsp90.

Definition

ChEBI: 4-chloro-6-{5-[(2-morpholin-4-ylethyl)amino]-1,2-benzisoxazol-3-yl}benzene-1,3-diol is a member of the class of 1,2-benzoxazoles carrying 2,4-dihydroxy-4-chlorophenyl and (2-morpholin-4-ylethyl)amino substituents at positions 3 and 5 respectively. It has a role as a Hsp90 inhibitor. It is a member of 1,2-benzoxazoles, a member of morpholines, a member of resorcinols, a member of monochlorobenzenes, a tertiary amino compound, a secondary amino compound and an aromatic amine.

CAY10607 Preparation Products And Raw materials

Raw materials

Preparation Products

CAY10607 Suppliers

Global( 19)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
Energy Chemical 021-58432009 400-005-6266 marketing1@energy-chemical.com China 44843 58
Shanghai Yiyan Biotechnology Co. , Ltd. 021-69985186 13611928337 3427709316@qq.com China 7984 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8740 58
Supplier Advantage
Aladdin Scientific 		58
Shanghai Hongye Biotechnology Co. Ltd 58
Energy Chemical 58
Shanghai Yiyan Biotechnology Co. , Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
CAY10607 Benzisoxazole Hsp90 Inhibitor CAY10607 Exclusive 1,3-Benzenediol, 4-chloro-6-[5-[[2-(4-morpholinyl)ethyl]amino]-1,2-benzisoxazol-3-yl]- 1012788-65-6