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2-Acetylthiophene

2-Acetylthiophene structure

CAS No.: 88-15-3

Chemical Name:: 2-Acetylthiophene

Synonyms: Ethanone, 1-(2-thienyl)-;AKOS 91936;2-Acetylthioph;2-Acetothienone;2-Acetylthiophen;2-ACETYLTHIOLE;2-ACETOTHIOPHENE;-Acetylthiophene;2-ACETYLTHIOPHENE;AKOS BBS-00000940

CBNumber:: CB5259889

Molecular Formula:: C6H6OS

Molecular Weight:: 126.18

MDL Number:: MFCD00005442

MOL File:: 88-15-3.mol

MSDS File:: SDS

Last updated:2024-04-26 17:21:34

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2-Acetylthiophene Properties

Melting point	10-11 °C (lit.)
Boiling point	214 °C (lit.)
Density	1.168 g/mL at 25 °C (lit.)
vapor pressure	2.7 hPa (50 °C)
refractive index	n20/D 1.565(lit.)
Flash point	196 °F
storage temp.	Store below +30°C.
solubility	14g/l
form	Liquid
color	Clear pale yellow to light brown
Odor	at 100.00 %. sulfurous nutty hazelnut walnut
Odor Type	sulfurous
Water Solubility	Insoluble in water.
Sensitive	Light Sensitive
BRN	107910
InChIKey	WYJOVVXUZNRJQY-UHFFFAOYSA-N
LogP	1.250
CAS DataBase Reference	88-15-3(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	5ASO208T20
NIST Chemistry Reference	Ethanone, 1-(2-thienyl)-(88-15-3)
EPA Substance Registry System	Ethanone, 1-(2-thienyl)- (88-15-3)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H300+H330-H311

Precautionary statements

P260-P264-P270-P280-P302+P352+P312-P304+P340+P310

Hazard Codes

T,Xi,Xn

Risk Statements

25-23/24/25-20/21/22

Safety Statements

45-38-36/37/39-28-36

RIDADR

UN 2810 6.1/PG 2

WGK Germany

RTECS

OB6300000

Autoignition Temperature

265 °C DIN 51794

Hazard Note

Irritant

TSCA

Yes

HazardClass

6.1

PackingGroup

HS Code

29349990

Toxicity

LD50 orally in Rabbit: 25 - 200 mg/kg LD50 dermal Rat 370 mg/kg

NFPA 704

	2
1		0

2-Acetylthiophene price More Price(39)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	A22602	2-Acetylthiophene 98%	88-15-3	25g	$38	2023-06-20	Buy
Sigma-Aldrich	W503509	2-Acetylthiophene ≥98%, FG	88-15-3	250g	$173	2023-06-20	Buy
Sigma-Aldrich	W503509	2-Acetylthiophene ≥98%, FG	88-15-3	1kg	$521	2023-01-07	Buy
Sigma-Aldrich	8.00175	2-Acetylthiophene for synthesis	88-15-3	50mL	$110	2023-01-07	Buy
Sigma-Aldrich	8.00175	2-Acetylthiophene for synthesis	88-15-3	250ML	$450	2023-01-07	Buy

Product number	Packaging	Price	Buy
A22602	25g	$38	Buy
W503509	250g	$173	Buy
W503509	1kg	$521	Buy
8.00175	50mL	$110	Buy
8.00175	250ML	$450	Buy

2-Acetylthiophene Chemical Properties,Uses,Production

Description

2-Acetylthiophene occurs naturally in kohlrabi. It has a sulfurous nutty hazelnut odor. It can be used as a food additive. It is also used as an intermediate to produce drugs, such as Tiamonium Iodide, Suprofan, Stepronin, Tenonitrozole, Namirotene, etc.

Chemical Properties

clear colorless to slightly yellow liquid

Uses

2-Acetylthiophene(2AT) is used as an intermediate in the manufacturing of drugs like Tiamonium Iodide, Suprofan, Stepronin, Tenonitrozole, Namirotene, etc. 2AT is used as an important precursor to thiophene-2-acetic acid (T2AA) or its acid chloride (Cl) and thiophene-2-carboxylic acid (T2CA) (Cl). It is important that the process used to synthesize 2AT yields the lowest amount of 3- acetylthiophene isomer.

Definition

ChEBI: 2-Acetylthiophene is an aromatic ketone.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 2, p. 8, 1943
The Journal of Organic Chemistry, 36, p. 540, 1971 DOI: 10.1021/jo00803a011
Tetrahedron Letters, 40, p. 3109, 1999 DOI: 10.1016/S0040-4039(99)00476-1

Safety Profile

Poison by intraperitoneal route. A flammable liquid. When heated to decomposition emits toxic fumes of SOx,.

Purification Methods

Fractionally distil the thiophene through a 12-plate column, and fraction b 77o/4mm is collected. Also wet the acetylthiophene in order to remove and free thiophene which forms an azeotrope with H2O, b 68o. Store it in a brown bottle, and the clear colourless liquid remains thus for extended periods. [Kosak & Hartough Org Synth Coll Vol III 14 1955, Hartough & Kosak J Am Chem Soc 69 3093 1947.] The red 4-nitrophenylhydrazone crystallises from EtOH with m 181-182o. [Beilstein 17/9 V 387.]

2-Acetylthiophene Preparation Products And Raw materials

Raw materials

Acetyl chloride

Preparation Products

5-[2-(METHYLTHIO)PYRIMIDIN-4-YL]THIOPHENE-2-SULFONYL CHLORIDE 1-(4-BROMO-2-THIENYL)ETHAN-1-ONE 5-THIEN-2-YL-4H-PYRAZOLE-3-CARBOXYLIC ACID Ethyl 5-thien-2-yl-1H-pyrazole-3-carboxylate N-(2-THIOPHENECARBOMYL)PYRIDINIUM BROMIDE

3-OXO-3-THIOPHEN-2-YL-PROPIONIC ACID ETHYL ESTER 4-Bromo-2-thiophenecarboxylic acid 5-ACETYL-2-THIOPHENECARBALDEHYDE 2-Thiopheneacetic acid 2-(2-BROMOACETYL)THIOPHENE

2-Acetyl-5-bromothiophene 2-(2-thienyl)propionic acid 1-[2-Hydroxy-2(2-thienyl)ethyl]pyridinium bromide 2,4-DIOXO-4-THIOPHEN-2-YL-BUTYRIC ACID METHYL ESTER 5-(2-sulfanylidene-3H-1,3-thiazol-4-yl)thiophene-2-carboxamide

THIOPHENE-2-ACETAMIDE 1,3,5-tri(thiophen-2-yl)benzene 2-ACETYL-4-CHLOROTHIOPHENE 2,5-Dihydrothiophene 2-THIENYL-2-DIMETHYLAMINOETHYL KETONE HCL

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2-Acetylthiophene Suppliers

Global( 683)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Yingrui Biopharma Co.,Ltd	21-33585366	export01@shyrchem.com	CHINA	1320	58
Hebei Guanlang Biotechnology Co,.LTD	+8619930503252	daisy@crovellbio.com	China	5963	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	18232	58
airuikechemical co., ltd.	+undefined86-15315557071	sales05@airuikechemical.com	China	994	58
Ouhuang Engineering Materials (Hubei) Co., Ltd	+8617702722807	admin@hbouhuang.com	China	3001	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15957	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21689	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9341	55
Nanjing Finetech Chemical Co., Ltd.	025-85710122 17714198479	sales@fine-chemtech.com	CHINA	885	55

Supplier	Advantage
Shanghai Yingrui Biopharma Co.,Ltd	58
Hebei Guanlang Biotechnology Co,.LTD	58
Henan Fengda Chemical Co., Ltd	58
airuikechemical co., ltd.	58
Ouhuang Engineering Materials (Hubei) Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Nanjing Finetech Chemical Co., Ltd.	55

View Lastest Price from 2-Acetylthiophene manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-04-27	2-Acetylthiophene 88-15-3	US $15.00 / kg	1kg	99.912%	10ton	Ouhuang Engineering Materials (Hubei) Co., Ltd
2024-04-07	2-Acetylthiophene 88-15-3	US $0.00-0.00 / g	1g	99.9%	20 tons	airuikechemical co., ltd.
2024-01-23	2-Acetylthiophene 88-15-3	US $9.00-0.90 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd

2-Acetylthiophene
88-15-3
US $15.00 / kg
99.912%
Ouhuang Engineering Materials (Hubei) Co., Ltd

2-Acetylthiophene
88-15-3
US $0.00-0.00 / g
99.9%
airuikechemical co., ltd.

2-Acetylthiophene
88-15-3
US $9.00-0.90 / KG
99%
Henan Fengda Chemical Co., Ltd

2-Acetylthiophene Spectrum

2-Acetylthiophene(88-15-3)MS 2-Acetylthiophene(88-15-3)¹HNMR 2-Acetylthiophene(88-15-3)¹³CNMR 2-Acetylthiophene(88-15-3)IR1 2-Acetylthiophene(88-15-3)Raman

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1-(2-THIENYL)ETHAN-1-ONE AKOS BBS-00000940 2-ACETYLTHIOLE 2-ACETYLTHIOPHENE 2-ACETOTHIOPHENE LABOTEST-BB LT01593557 METHYL 2-THIENYL KETONE 2-ACETYLTHIOPHENE 98+% 2-Acetylthiophene99% acetylthiophene,2-acetylthiophene 2-ACETYLBROMOTHIOPHENE 1-(2-Thienyl)-1-ethanone 1-(Thien-2-yl)ethan-1-one 2-Acetylthiophene, 98% 100GR METHYL 2-THIENYL KETONE FOR SYNTHESIS 1-(2-thienyl)-ethanon 1-thiophen-2-yl-ethanone 2-acethylthiophene 2-Thienyl methyl ketone 2-thienylmethylketone alpha-acetylthiophene Ketone, methyl 2-thienyl ketone,methyl2-thienyl thiophene,2-acetyl- 2 - thiophene ethyl ketone 2-Acetylthiophene in stock Factory 2-Acetylthiophene > High Quality 2-Acetylthiophene 2-Acetylthiophene USP/EP/BP 2-Acetylthiophene (Stellar-2002) 2-Acetyl Thiophene pure, 99% AKOS 91936 Ethanone, 1-(2-thienyl)- 2-Acetothienone 2-Acetylthiophen 2-Acetylthioph Avatrombopag Impurity 95 -Acetylthiophene Aficamten Impurity 11 5-BROMO-4-(THIOPHEN-2-YL)-1,3-THIAZOL-2-AMINE Acetonitrile Dried Special 88-15-3 8-15-3 CH3COC4H3S Thiophenes Heterocyclic Building Blocks KETONE Building Blocks Heterocycle-oher series Sulphur Derivatives Thiophene&Benzothiophene thiophene Flavor Thiophenes 1 bc0001