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ChemicalBook >> CAS DataBase List >>2-Amino-4-bromo-3-fluorobenzoic acid

2-Amino-4-bromo-3-fluorobenzoic acid

2-Amino-4-bromo-3-fluorobenzoic acid Structure
2-Amino-4-bromo-3-fluorobenzoic acid structure
CAS No.
1416013-62-1
Chemical Name:
2-Amino-4-bromo-3-fluorobenzoic acid
Synonyms
140622;Ethanol,5-diazenyl-;Oxymetazoline Impurity 10;3-BROMO-6-CARBOXY-2-FLUOROANILINE;2-amino-4-bromo-3-fluorobenzoicaci;2-Amino-3-fluoro-4-bromobenzoic acid;2-Amino-4-bromo-3-fluorobenzoic acid;Benzoic acid, 2-amino-4-bromo-3-fluoro-
CBNumber:
CB52697454
Molecular Formula:
C7H5BrFNO2
Molecular Weight:
234.02
MDL Number:
MFCD27664889
MOL File:
1416013-62-1.mol
MSDS File:
SDS
Last updated:2024-02-07 11:55:47
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2-Amino-4-bromo-3-fluorobenzoic acid Properties

Boiling point 332.0±42.0 °C(Predicted)
Density 1.877±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2–8 °C
pka 4.37±0.10(Predicted)
form powder
color Off white

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P271-P261-P280
HS Code  2922498590

2-Amino-4-bromo-3-fluorobenzoic acid price More Price(24)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC A577113 2-Amino-4-Bromo-3-FluorobenzoicAcid 1416013-62-1 1g $45 2021-12-16 Buy
Apolloscientific PC500189 2-Amino-4-bromo-3-fluorobenzoicacid 95% 1416013-62-1 1g $67 2021-12-16 Buy
SynQuest Laboratories 4657-B-00 2-Amino-4-bromo-3-fluorobenzoic acid 1416013-62-1 250mg $72 2021-12-16 Buy
AK Scientific Y1761 2-Amino-4-bromo-3-fluorobenzoicacid 1416013-62-1 100mg $80 2021-12-16 Buy
Apolloscientific PC500189 2-Amino-4-bromo-3-fluorobenzoicacid 95% 1416013-62-1 250mg $37 2021-12-16 Buy
Product number Packaging Price Buy
A577113 1g $45 Buy
PC500189 1g $67 Buy
4657-B-00 250mg $72 Buy
Y1761 100mg $80 Buy
PC500189 250mg $37 Buy

2-Amino-4-bromo-3-fluorobenzoic acid Chemical Properties,Uses,Production

Description

2-Amino-4-bromo-3-fluorobenzoic acid is an important pharmaceutical and organic intermediate ingredient used in the synthesis of avibactam sodium, an FDA-approved non-beta-lactam β-lactamase inhibitor used in combination with ceftazidime (Avycaz). It is used for the treatment of complicated intra-abdominal infections, urinary tract infections, and pyelonephritis.

Uses

2-Amino-4-Bromo-3-Fluorobenzoic Acid is used in preparation of Quinazoline compounds as KRAS modulators and antitumor agents.

Synthesis

The synthesis of 2-Amino-4-bromo-3-fluorobenzoic acid is as follows:
To a mixture of 6-bromo-7-fluoroindoline-2,3-dione (18.9 g, 77.5 mmol) in 2 N NaOH (350 mL) at 0 oC, H2O2 (30%, 40 mL) was added. The mixture was stirred at room temperature for 16 h. The mixture was quenched with Na2SO3, and the mixture was acidified with conc. HCl to adjust pH to 2. The precipitate was collected by filtration and dried to afford the desired product as a white solid (17 g, 94% yield).
synthesis of 2-Amino-4-bromo-3-fluorobenzoic acid.png

2-Amino-4-bromo-3-fluorobenzoic acid synthesis

1336963-95-1
1416013-62-1
Synthesis of 2-Amino-4-bromo-3-fluorobenzoic acid from 6-bromo-7-fluoroisatin

2-Amino-4-bromo-3-fluorobenzoic acid Preparation Products And Raw materials

Raw materials

6-bromo-7-fluoroisatin 4-BROMO-2,3-DIFLUOROBENZOIC ACID

Preparation Products

2-Amino-4-bromo-3-fluorobenzoic acid Suppliers

Global( 161)Suppliers
Supplier Tel Email Country ProdList Advantage
WinWin Chemical CO., Limited 		+86-0577-64498589 +8615325081899 sales@win-winchemical.com China 14145 58
Amadis Chemical Company Limited
571-89925085 sales@amadischem.com China 131980 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Zjartschem 		+86-571-8723 8903 jocelynpan@zjarts.com jocelynpan@zjarts.com CHINA 993 58
Win-Win Chemical CO., Limited 		0086-577-64498589 sales@win-winchemical.com CHINA 998 58
Changzhou Ansciep Chemical Co., Ltd. 		+86 519 86305871 sales@ansciepchem.com CHINA 4242 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10247 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830 figo.gao@foxmail.com China 7154 58
Jinan Finer Chemical Co., Ltd 		+86-531-88989536 +86-15508631887 sales@finerchem.com China 2966 58
Accela ChemBio Inc. 		(+1)-858-699-3322 info@accelachem.com United States 19965 58
Supplier Advantage
WinWin Chemical CO., Limited 		58
Amadis Chemical Company Limited
58
Capot Chemical Co.,Ltd. 		60
Zjartschem 		58
Win-Win Chemical CO., Limited 		58
Changzhou Ansciep Chemical Co., Ltd. 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Jinan Carbotang Biotech Co.,Ltd. 		58
Jinan Finer Chemical Co., Ltd 		58
Accela ChemBio Inc. 		58

View Lastest Price from 2-Amino-4-bromo-3-fluorobenzoic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Amino-4-bromo-3-fluorobenzoic acid pictures 2020-01-01 2-Amino-4-bromo-3-fluorobenzoic acid
1416013-62-1
 US $1.00 / KG 1KG 99% 200kg Career Henan Chemical Co

2-Amino-4-bromo-3-fluorobenzoic acid Spectrum

2-Amino-4-bromo-3-fluorobenzoic acid(1416013-62-1)1HNMR

1416013-62-1(2-Amino-4-bromo-3-fluorobenzoic acid)Related Search:

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2-Amino-4-bromo-3-fluorobenzoic acid 3-BROMO-6-CARBOXY-2-FLUOROANILINE 140622 Benzoic acid, 2-amino-4-bromo-3-fluoro- Ethanol,5-diazenyl- 2-amino-4-bromo-3-fluorobenzoicaci Oxymetazoline Impurity 10 2-Amino-3-fluoro-4-bromobenzoic acid 1416013-62-1