Propargyl-PEG4-Tos
- CAS No.
- 875770-32-4
- Chemical Name:
- Propargyl-PEG4-Tos
- Synonyms
- Propargyl-PEG5-Tos;Propargyl-PEG4-Tos;3,6,9,12-tetraoxapentadec-14-yn-1-yl 4-methylbenzene-1-sulfonate;3,6,9,12-Tetraoxapentadec-14-yn-1-ol, 1-(4-methylbenzenesulfonate)
- CBNumber:
- CB53062628
- Molecular Formula:
- C18H26O7S
- Molecular Weight:
- 386.46
- MDL Number:
- MFCD28950765
- MOL File:
- 875770-32-4.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
Propargyl-PEG4-Tos price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Synthonix | P8651 | Propargyl-PEG5-Tos 95% | 875770-32-4 | 50mg | $180 | 2021-12-16 | Buy |
| Synthonix | P8651 | Propargyl-PEG5-Tos 95% | 875770-32-4 | 100mg | $280 | 2021-12-16 | Buy |
| Synthonix | P8651 | Propargyl-PEG5-Tos 95% | 875770-32-4 | 250mg | $380 | 2021-12-16 | Buy |
| BroadPharm | BP-22781 | Propargyl-PEG5-Tos 98% | 875770-32-4 | 250mg | $450 | 2021-12-16 | Buy |
| Synthonix | P8651 | Propargyl-PEG5-Tos 95% | 875770-32-4 | 500mg | $580 | 2021-12-16 | Buy |
Propargyl-PEG4-Tos Chemical Properties,Uses,Production
Description
Propargyl-PEG5-Tos is a PEG linker containing a tosyl group and a propargyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage.
Biological Activity
Propargyl-PEG4-Tos is a PROTAC linker belonging to the PEG class and can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| PEGs
| Cleavable
|
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Wuhan Borenpharm Co., Ltd | 027-65563561 18717150066 | 3207347307@qq.com | CHINA | 1238 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3149 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
| Xian confluore Biological Technology Co., Ltd. | +86-15680926068 +86-15680926068 | 1924344760@confluore.cn | China | 2996 | 58 |
| Daicel Chiral Technologies (China)CO.,LTD | 021-50460086-9 15921403865 | han_yajun@dctc.daicel.com | China | 6854 | 65 |
| Bide Pharmatech Ltd. | 400-1647117 15221909166 | product02@bidepharm.com | China | 41438 | 60 |
| Borenpharm Co., Ltd | 027-65563561 | sales@borenpharm.com | China | 1246 | 55 |
| Jinan elephant international trading co., LTD | 13006575422@163.com | China | 6357 | 58 |
View Lastest Price from Propargyl-PEG4-Tos manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-26 | Propargyl-PEG5-Tos
875770-32-4
|
US $0.00 / g | 5g | >95.00% | 5g | Xian confluore Biological Technology Co., Ltd. |
-
- Propargyl-PEG5-Tos
875770-32-4
- US $0.00 / g
- >95.00%
- Xian confluore Biological Technology Co., Ltd.
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