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ChemicalBook >> CAS DataBase List >>(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide

(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide

(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide Structure
(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide structure
CAS No.
1196504-54-7
Chemical Name:
(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide
Synonyms
EOS-62352;GDC0575 hydrochloride;GDC0575 monohydrochloride;GDC0575 monohydrochloride,GDC-0575 monohydrochloride;(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide
CBNumber:
CB53142373
Molecular Formula:
C16H21BrClN5O
Molecular Weight:
414.73
MDL Number:
MFCD32669797
MOL File:
1196504-54-7.mol
Last updated:2023-09-20 16:43:00
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(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth Carbosynth FG172882 GDC 0575 hydrochloride 1196504-54-7 50mg $1100 2021-12-16 Buy
Biosynth Carbosynth FG172882 GDC 0575 hydrochloride 1196504-54-7 100mg $1350 2021-12-16 Buy
Biosynth Carbosynth FG172882 GDC 0575 hydrochloride 1196504-54-7 250mg $2400 2021-12-16 Buy
Biosynth Carbosynth FG172882 GDC 0575 hydrochloride 1196504-54-7 500mg $2850 2021-12-16 Buy
AK Scientific 2505DT GDC0575hydrochloride 1196504-54-7 500mg $3897 2021-12-16 Buy
Product number Packaging Price Buy
FG172882 50mg $1100 Buy
FG172882 100mg $1350 Buy
FG172882 250mg $2400 Buy
FG172882 500mg $2850 Buy
2505DT 500mg $3897 Buy

(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide Chemical Properties,Uses,Production

Description

GDC-0575, also known as ARRY-575 and RG7741, is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2?nM. Chk1 inhibitor GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells bypassing Chk1-dependent cell cycle arrest in the S and G2/M phases, which permits the cells to undergo DNA repair prior to entry into mitosis.

in vitro

CHK1 inhibitor (CHK1i) GDC-0575 enhances AraC-mediated killing of AML cells both in vitro and in vivo, thus abrogating any potential chemoresistance mechanisms involving DNA repair._x000D_ _x000D_ Reference: Nat Commun. 2017 Nov 22;8(1):1679. https://pubmed.ncbi.nlm.nih.gov/29162833/

target

GDC-0575 (ARRY-575, RG7741) is a highly-selective oral small-molecule Chk1 inhibitor with an IC50 of 1.2?nM.

(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide Preparation Products And Raw materials

Raw materials

Preparation Products

(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide Suppliers

Global( 14)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32715 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
ShangHai Biochempartner Co.,Ltd 17754423994 17754423994 2853530910@QQ.com China 8011 62
Jinan elephant international trading co., LTD 13006575422@163.com China 6357 58
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136 info@SuperLan-chem.com China 9779 58
Shanghai zhigan biotechnology co., LTD zhiqianbio@126.com China 19785 58
Shanghai Dongyang Biotechnology Co., Ltd. 0512-0512-13601744364 13601744364 chemsharker@126.com China 881 58
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9414 58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd. 021-51816796-820 13611835272 sales2@sunwaypharm.com China 44486 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24018 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
ShangHai Biochempartner Co.,Ltd 62
Jinan elephant international trading co., LTD 58
Shanghai Chaolan Chemical Technology Center 58
Shanghai zhigan biotechnology co., LTD 58
Shanghai Dongyang Biotechnology Co., Ltd. 58
DC Chemicals 58
Shanghai Sunway Pharmaceutical Technology Co.,Ltd. 58
TargetMol Chemicals Inc. 58

(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide Spectrum

(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide(1196504-54-7)1HNMR

1196504-54-7((R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide)Related Search:

giredestrant (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide GDC0575 2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide GDC-0077
(S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one XL518 DONEPEZIL HYDROCHLORIDE

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(R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide EOS-62352 GDC0575 hydrochloride GDC0575 monohydrochloride GDC0575 monohydrochloride,GDC-0575 monohydrochloride 1196504-54-7