5-(N,N-dimethyl)-Amiloride (hydrochloride)
- CAS No.
- 2235-97-4
- Chemical Name:
- 5-(N,N-dimethyl)-Amiloride (hydrochloride)
- Synonyms
- Venlafaxine Impurity 31;Dimethylamiloride hydrochloride;N)-Dimethylamiloride Hydrochloride;Dimethylamiloride hydrochloride (5-(N,N-Dimethyl)amiloride hydrochloride)
- CBNumber:
- CB53152503
- Molecular Formula:
- C8H13Cl2N7O
- Molecular Weight:
- 294.141
- MDL Number:
- MFCD00069207
- MOL File:
- 2235-97-4.mol
| Melting point | 298 °C (decomp) |
|---|---|
| storage temp. | Store at -20°C |
| solubility | ≤30mg/ml in DMSO;30mg/ml in dimethyl formamide |
| form | crystalline solid |
| FDA UNII | 52W30K1Q9Q |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
5-(N,N-dimethyl)-Amiloride (hydrochloride) price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19100 | 5-(N,N-dimethyl)-Amiloride (hydrochloride) ≥98% | 2235-97-4 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 19100 | 5-(N,N-dimethyl)-Amiloride (hydrochloride) ≥98% | 2235-97-4 | 5mg | $116 | 2024-03-01 | Buy |
| TRC | D470570 | 5-(N,N-Dimethyl)amiloride hydrochloride | 2235-97-4 | 50mg | $400 | 2021-12-16 | Buy |
| TRC | D470570 | 5-(N,N-Dimethyl)amiloride hydrochloride | 2235-97-4 | 100mg | $755 | 2021-12-16 | Buy |
| ApexBio Technology | C3505 | 5-(N,N-Dimethyl)amiloride hydrochloride | 2235-97-4 | 5mg | $130 | 2021-12-16 | Buy |
5-(N,N-dimethyl)-Amiloride (hydrochloride) Chemical Properties,Uses,Production
Uses
5-(N,N-dimethyl)-Amiloride (hydrochloride)?has been used to investigate biochemical processes related to the circadian clock in mouse and human cell lines. It can also inhibit sodium-hydrogen exchangers (NHE). NHEs regulate sodium and pH in various tissues.
Biological Activity
5-(n, n-dimethyl)-amiloride (hydrochloride), a derivative of amiloride, is an inhibitor of nhe1, nhe2, and nhe3.the na+/h+ exchanger (nhe) is a protein that has been involved in intracellular ph homeostasis of many mammalian cell types. nhe is involved in regulating intracellular ph and cell volume by extruding protons from, and taking up sodium ions into cells [1].5-(n, n-dimethyl)-amiloride (dma) inhibited nhe1, nhe2, and nhe3 with ki values of 0.02, 0.25, and 14 μm, respectively. dma showed little or no effects on nhe4, nhe5, and nhe7 [1]. dma could effectively protect the right ventricular wall against ischemia-reperfusion dysfunction in the presence or absence of ouabain [2]. dma protected against severe reperfusion-induced cardiac contractile dysfunction, appeared to act via a normalization of tissue sodium levels [2]. dma (0.2 mm) completely inhibited phi recovery after cell acidification and blocked egf-induced cytoprotection against acid [3].in primary rat hepatocyte cultures and rat liver plasma membranes, dma increased steady-state na+ content and inhibited ouabain-sensitive 86rb+ uptake in a reversible, concentration-dependent, ouabain-like manner, with estimated ic50 of 5.2×10-4 m. dma also inhibited ouabain-sensitive atp hydrolysis in rat liver plasma membranes with ic50 value of 2.2 ×10-3 m. dma (10-3 m) decreased the uptake into hepatocytes of alanine by 61% [4].
References
[1] masereel b, pochet l, laeckmann d. an overview of inhibitors of na+/h+ exchanger[j]. european journal of medicinal chemistry, 2003, 38(6): 547-554.
[2] meng h, pierce g n. involvement of sodium in the protective effect of 5-(n, n-dimethyl)-amiloride on ischemia-reperfusion injury in isolated rat ventricular wall[j]. journal of pharmacology and experimental therapeutics, 1991, 256(3): 1094-1100.
[3] fujiwara y, higuchi k, takashima t, et al. roles of epidermal growth factor and na+/h+ exchanger-1 in esophageal epithelial defense against acid-induced injury[j]. american journal of physiology-gastrointestinal and liver physiology, 2006, 290(4): g665-g673.
[4] renner e l, lake j r, cragoe e j, et al. amiloride and amiloride analogs inhibit na+/k+-transporting atpase and na+-coupled alanine transport in rat hepatocytes[j]. biochimica et biophysica acta (bba)-biomembranes, 1988, 938(3): 386-394.
5-(N,N-dimethyl)-Amiloride (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
5-(N,N-dimethyl)-Amiloride (hydrochloride) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Wuhan Topule | +86-02787215551 +86-19945035818 | 2936752263@qq.com | China | 8287 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |
| Xianning Shen Lan Biomedical Research and Development Co., Ltd. | 18171815831 | 1341138380@qq.com | China | 2780 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| guoyungurui | 18162595016 | 3287908757@qq.com | China | 10012 | 58 |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | +86-18521732826 | market@aladdin-e.com | China | 48467 | 58 |
| Olix (Shanghai) Pharmaceutical Technology Co., Ltd | 17316404525 | 209533805@qq.com | China | 9621 | 58 |