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JNJ-42847922

JNJ-42847922 Structure
JNJ-42847922 structure
CAS No.
1293281-49-8
Chemical Name:
JNJ-42847922
Synonyms
JNJ-42847922;JNJ-42847922,Cid 67116280;Seltorexant (JNJ-42847922);[5-(4,6-dimethyl-pyrimidin-2-yl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-(2-fluoro-6-[1,2,3]triazol-2-yl-phenyl)-methanone;[2-(4,6-DIMETHYLPYRIMIDIN-2-YL)-1,3,3A,4,6,6A-HEXAHYDROPYRROLO[3,4-C]PYRROL-5-YL]-[2-FLUORO-6-(TRIAZOL-2-YL)PHENYL]METHANONE;Methanone, [5-(4,6-dimethyl-2-pyrimidinyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl][2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl]-;Hypocretin Receptor,JNJ42847922,HCRT Receptor,Orexin Receptor (OX Receptor),Seltorexant,movement,barrier,insomnia,somnolence,eye,blood-brain,inhibit,rapid,selective,sleep,JNJ 42847922,Inhibitor
CBNumber:
CB53369745
Molecular Formula:
C21H22FN7O
Molecular Weight:
407.44
MDL Number:
MFCD31700700
MOL File:
1293281-49-8.mol
Last updated:2023-09-20 16:43:00
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JNJ-42847922 Properties

Boiling point 667.7±65.0 °C(Predicted)
Density 1.46±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 250 mg/mL (613.59 mM)
pka 6.50±0.50(Predicted)
FDA UNII AIS8N3O50B

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS06
Signal word  Danger
Hazard statements  H312-H319-H301-H335-H332-H315
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P261-P271-P304+P340-P312-P264-P270-P301+P310-P321-P330-P405-P501-P280-P302+P352-P312-P322-P363-P501

JNJ-42847922 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0030510 Seltorexant 99.51% 1293281-49-8 100mg $1432 2021-12-16 Buy
ChemScene CS-0030510 Seltorexant 99.51% 1293281-49-8 250mg $2386 2021-12-16 Buy
Chemenu CM337143 [2-(4,6-dimethylpyrimidin-2-yl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-[2-fluoro-6-(triazol-2-yl)phenyl]methanone 95%+ 1293281-49-8 250mg $4343 2021-12-16 Buy
Chemenu CM337143 [2-(4,6-dimethylpyrimidin-2-yl)-1,3,3a,4,6,6a-hexahydropyrrolo[3,4-c]pyrrol-5-yl]-[2-fluoro-6-(triazol-2-yl)phenyl]methanone 95%+ 1293281-49-8 100mg $2234 2021-12-16 Buy
Product number Packaging Price Buy
CS-0030510 100mg $1432 Buy
CS-0030510 250mg $2386 Buy
CM337143 250mg $4343 Buy
CM337143 100mg $2234 Buy

JNJ-42847922 Chemical Properties,Uses,Production

Description

Seltorexant, also known as JNJ-42847922 and MIN-202, is a potent OX2R antagonist that has been shown to promote sleep in various species. JNJ-42847922 had an approximate 2-log selectivity ratio versus the human orexin-1 receptor. Ex vivo receptor binding studies demonstrated that JNJ-42847922 quickly occupied OX2R binding sites in the rat brain after oral administration and rapidly cleared from the brain. Seltorexant shows antidepressant and sleep-promoting effects in patients with major depressive disorder. JNJ-42847922 induces somnolence in healthy subjects without residual central effects.

JNJ-42847922 synthesis

1186050-58-7
1293284-71-5
1293281-49-8
Synthesis of JNJ-42847922 from 2-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid and Pyrrolo[3,4-c]pyrrole, 2-(4,6-dimethyl-2-pyrimidinyl)octahydro-

JNJ-42847922 Preparation Products And Raw materials

Raw materials

Benzoyl chloride, 2-fluoro-6-(2H-1,2,3-triazol-2-yl)- Pyrrolo[3,4-c]pyrrole, 2-(4,6-dimethyl-2-pyrimidinyl)octahydro- 5-Benzyl-2-Boc-hexahydro-pyrrolo[3,4-C]pyrrole 2-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid 3-Benzyl-3,7-diazabicyclo[3.3.0]octane
2-BOC-HEXAHYDRO-PYRROLO[3,4-C]PYRROLE 2-FLUORO-6-IODOBENZOIC ACID

1of2

Preparation Products

JNJ-42847922 Suppliers

Global( 42)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32715 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6313 58
Finetech Industry Limited 		+86-27-87465837 +8618971612321 info@finetechnology-ind.com China 9634 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8474 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57511 58
Suzhou ARTK Medchem Co., Ltd. 		+86-512-68323967 +86-18015559028 sales1@artkmedchem.com China 39009 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139 orders@jknbiochem.com China 4691 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 sales-cpd@caerulumpharma.com China 3423 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Finetech Industry Limited 		58
InvivoChem 		58
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Aladdin Scientific 		58
Suzhou ARTK Medchem Co., Ltd. 		58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		58
ShangHai Caerulum Pharma Discovery Co., Ltd. 58

JNJ-42847922 Spectrum

JNJ-42847922(1293281-49-8)1HNMR
[2-(4,6-DIMETHYLPYRIMIDIN-2-YL)-1,3,3A,4,6,6A-HEXAHYDROPYRROLO[3,4-C]PYRROL-5-YL]-[2-FLUORO-6-(TRIAZOL-2-YL)PHENYL]METHANONE JNJ-42847922 JNJ-42847922,Cid 67116280 [5-(4,6-dimethyl-pyrimidin-2-yl)-hexahydro-pyrrolo[3,4-c]pyrrol-2-yl]-(2-fluoro-6-[1,2,3]triazol-2-yl-phenyl)-methanone Methanone, [5-(4,6-dimethyl-2-pyrimidinyl)hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl][2-fluoro-6-(2H-1,2,3-triazol-2-yl)phenyl]- Seltorexant (JNJ-42847922) Hypocretin Receptor,JNJ42847922,HCRT Receptor,Orexin Receptor (OX Receptor),Seltorexant,movement,barrier,insomnia,somnolence,eye,blood-brain,inhibit,rapid,selective,sleep,JNJ 42847922,Inhibitor 1293281-49-8 API