1400W
- CAS No.
- 180001-34-7
- Chemical Name:
- 1400W
- Synonyms
- 1400W DIHYDROCHLORIDE;400W;1400W;W 1400;N-(3-(AMINOMETHYL)BENZYL)ACETAMIDINE;N-(3-(aminomethyl)benzyl)acetimidamide;N-(3-(AMINOMETHYL)BENZYL)ACETAMIDINE 2HCL;Ethanimidamide, N-[[3-(aminomethyl)phenyl]methyl]-;N-(3-(AMINOMETHYL)BENZYL)ACETAMIDINE, DIHYDROCHLORIDE;N-[[3-(AMINOMETHYL)PHENYL]METHYL]-ETHANIMIDAMIDE DIHYDROCHLORIDE
- CBNumber:
- CB5343313
- Molecular Formula:
- C10H15N3
- Molecular Weight:
- 177.25
- MDL Number:
- MFCD01317835
- MOL File:
- 180001-34-7.mol
| Melting point | 208-220 °C |
|---|---|
| Boiling point | 301.7±44.0 °C(Predicted) |
| Density | 1.09±0.1 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility | DMSO, Methanol, Water |
| pka | 11.33±0.50(Predicted) |
| form | solid |
| color | White to Off-White |
| FDA UNII | M1VB8VP8OH |
SAFETY
Risk and Safety Statements
| Safety Statements | 22-24/25 |
|---|---|
| WGK Germany | 3 |
1400W price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 1415 | 1400W dihydrochloride ≥99%(HPLC) | 180001-34-7 | 10 | $125 | 2021-12-16 | Buy |
| Tocris | 1415 | 1400W dihydrochloride ≥99%(HPLC) | 180001-34-7 | 50 | $526 | 2021-12-16 | Buy |
| TRC | W400050 | W1400 | 180001-34-7 | 1mg | $165 | 2021-12-16 | Buy |
| Usbiological | 044436 | 1400W dihydrochloride | 180001-34-7 | 5mg | $282 | 2021-12-16 | Buy |
| Usbiological | 169589 | 1400W Dihydrochloride | 180001-34-7 | 5mg | $286 | 2021-12-16 | Buy |
1400W Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
A selective inducible nitric oxide synthase (iNOS) inhibitor. A long-acting human iNOS inhibitor possessing an IC50 value of 2.0uM
Uses
1400W selectively inhibits inducible nitric oxide synthase. W 1400 has been implicated to prevent Doxorubicin and Trastuzumab induced cardiotoxicity.
Definition
ChEBI: N-[3-(aminomethyl)benzyl]acetamidine is an aralkylamine that is Nbenzylacetamidine substituted at position 3 on the benzene ring by an aminomethyl group. An inhibitor of nitric oxide synthase. It has a role as an EC 1.14.13.39 (nitric oxide synthase) inhibitor, a geroprotector and an angiogenesis inhibitor. It is a carboxamidine, an aralkylamine and a primary amino compound.
Biological Activity
Slow, tight binding, potent and highly selective inhibitor of inducible nitric oxide synthase (K d = 7 nM). Selective over nNOS and eNOS (K i values are 2 and 50 μ M respectively). Cell-permeable and active in vivo .
1400W Preparation Products And Raw materials
Raw materials
Preparation Products
1400W Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| Ascent Scientific | 4401179829988 | customerservice@ascentscientific.co.uk | United Kingdom | 279 | 60 |
| Guangzhou Zhiya Chemdrugs Co.,Ltd | 18122150900 | sculk28@163.com | China | 646 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
| Chuzhou KeMail Chemical Technology Co., Ltd | 0550-5196001 15000891977 | wj520wjxby@126.com | China | 1836 | 55 |
| Tianjin Kaifu Pharmaceutical Technology Co., Ltd. | 18081075745 | chemflowtech@sina.com | China | 1886 | 58 |
| Shanghai Zeye Biotechnology Co., Ltd. | 021-61998551 13122364865 | sale1@shzysw.net | China | 9763 | 58 |
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