Nefopam hydrochloride
- CAS No.
- 23327-57-3
- Chemical Name:
- Nefopam hydrochloride
- Synonyms
- NEFOPAM HCL;ajan;r738;ACUPAN;NAFOPAN HCL;NEFOPAM HYDROCHLORIDE;LABOTEST-BB LT00159839;fenazoxinehydrochloride;Nefopam HCl (Fenazoxine);BENZOXAZOCINE HYDROCHLORIDE
- CBNumber:
- CB5379273
- Molecular Formula:
- C17H20ClNO
- Molecular Weight:
- 289.8
- MDL Number:
- MFCD00012750
- MOL File:
- 23327-57-3.mol
| Melting point | 238-242° |
|---|---|
| storage temp. | 2-8°C |
| solubility | H2O: soluble5mg/mL, clear |
| form | powder |
| color | white to beige |
| CAS DataBase Reference | 23327-57-3(CAS DataBase Reference) |
| FDA UNII | 685J48E13W |
| NCI Drug Dictionary | nefopam hydrochloride |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301+H311+H331 | |||||||||
| Precautionary statements | P261-P264-P280-P301+P310-P302+P352+P312-P304+P340+P311 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 23/24/25 | |||||||||
| Safety Statements | 36/37/39-45 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2933.49.2600 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| Toxicity | LD50 in mice, rats (mg/kg): 119, 178 orally; 44.5, 28 i.v. (Baltes) | |||||||||
| NFPA 704 |
|
Nefopam hydrochloride price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0909 | Nefopam hydrochloride ≥98% (HPLC) | 23327-57-3 | 10mg | $74.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0909 | Nefopam hydrochloride ≥98% (HPLC) | 23327-57-3 | 50mg | $290 | 2024-03-01 | Buy |
| TCI Chemical | N1169 | Nefopam Hydrochloride | 23327-57-3 | 1G | $40 | 2024-03-01 | Buy |
| TCI Chemical | N1169 | Nefopam Hydrochloride | 23327-57-3 | 5G | $62 | 2024-03-01 | Buy |
| TRC | N389400 | Nefopam Hydrochloride | 23327-57-3 | 250mg | $250 | 2021-12-16 | Buy |
Nefopam hydrochloride Chemical Properties,Uses,Production
Chemical Properties
White to Off-White Solid
Originator
Ajan,Kettelhack Riker,W. Germany,1976
Uses
Nefopam hydrochloride has been used as a standard for the quantitative determination of tramadol by gas chromatography–mass spectrometry (GC/MS).
Uses
A cyclized analog of orphenadrine and diphenhydramine; representative of a new class of centrally acting skeletal muscle relaxants, the benzoxazocines. Analgesic; antidepressant.
Manufacturing Process
The starting material is prepared by reacting 2-benzoylbenzoic acid with
thionyl chloride and then with 2-methylaminoethanol. 20.0 grams (0.07 mol)
of N-(2-hydroxyethyl)-N-methyl-o-benzoylbenzamide is suspended in 100 ml
tetrahydrofuran and then slowly added in small portions to a solution of 5.5
grams (0.14 mol) of lithium aluminum hydride in 150 ml tetrahydrofuran with
cooling and stirring. The mixture is then refluxed for 18 hours, cooled and
then to it is successively added 5.5 ml water, 5.5 ml of 3.75 N sodium
hydroxide and 16 ml water. After removal of precipitated salts by filtration, the
solution remaining is concentrated under reduced pressure and the residue
dried to yield 19.5 grams of crude product. Yield after conversion to the
hydrochloride salt and recrystallization is 17.0 grams (89%), MP 128° to
133°C.
5-methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f] -2,5-oxazocine is prepared
as follows. 3.0 grams (0.011 mol) of 2-([N-(2-hydroxyethyl)-Nmethyl]amino)methylbenzhydrol, prepared as described above, 3.0 grams ptoluenesulfonic acid and 15 ml benzene are heated together with stirring until
all the benzene is distilled off. The residual oil is heated to 105°C and held at
this temperature for 1 hour, then cooled and dissolved in 30 ml water. This
aqueous solution is then basified to pH 10.0 with 12 N sodium hydroxide,
extracted with ether, and the extracts washed with water, dried over
anhydrous sodium sulfate and the solvent removed under reduced pressure.
The 2.26 grams (81%) oil remaining is converted to the hydrochloride salt, MP
238° to 242°C.
brand name
Acupan (3M Pharmaceuticals).
Therapeutic Function
Muscle relaxant, Antidepressant
Biochem/physiol Actions
Nefopam is a centrally-acting analgesic drug of the benzoxazocine chemical class. Nefopam is a non-opioid, but has a potentiating effect on morphine and other opioids. Its mechanism of action is not certain, but may involve its action as a dopamine/serotonin/norepinephrine reuptake inhibitor.
Clinical Use
Analgesic for moderate pain
Drug interactions
Potentially hazardous interactions with other drugs
Antidepressants: avoid MAOIs; tricyclics possibly
increased risk of side effects.
Metabolism
Extensively metabolised in the liver to produce active metabolites. It is mainly excreted in the urine. About 8% of a dose is excreted via the faeces.
Nefopam hydrochloride Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Xiamen Wonderful Bio Technology Co., Ltd. | +8613043004613 | Sara@xmwonderfulbio.com | China | 305 | 58 |
| Liaoning Pharmaceutical Innovation Co., Ltd | +8616588669988 | sales@pipharma.com.cn | China | 150 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21689 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 | 1056@dideu.com | China | 3335 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10297 | 58 |
View Lastest Price from Nefopam hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-29 | Nefopam(Hydrochloride)
23327-57-3
|
US $0.00 / mg | 10mg | 0.98 | 10g | ShenZhen H&D Pharmaceutical Technology Co., LTD | |
 |
2024-03-22 | Nefopan Hydrochloride
23327-57-3
|
US $10.00-5.00 / kg | 1kg | 99% | 20000tons | Liaoning Pharmaceutical Innovation Co., Ltd | |
 |
2024-03-16 | Nefopam hydrochloride
23327-57-3
|
US $0.00 / KG | 100g | 98%+ | 100kg | WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD |
-
- Nefopam(Hydrochloride)
23327-57-3
- US $0.00 / mg
- 0.98
- ShenZhen H&D Pharmaceutical Technology Co., LTD
-
- Nefopan Hydrochloride
23327-57-3
- US $10.00-5.00 / kg
- 99%
- Liaoning Pharmaceutical Innovation Co., Ltd
-
- Nefopam hydrochloride
23327-57-3
- US $0.00 / KG
- 98%+
- WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
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