BD 1008 Dihydrobromide
- CAS No.
- 138356-09-9
- Chemical Name:
- BD 1008 Dihydrobromide
- Synonyms
- BD-1008 HBr;BD 1008 (hydrobromide);N-[2-(3,4-Dichlorophenyl)ethyl]-N-Methyl-1-pyrrolidineethanaMine DihydrobroMide;1-Pyrrolidineethanamine, N-[2-(3,4-dichlorophenyl)ethyl]-N-methyl-, hydrobromide (1:2)
- CBNumber:
- CB62503053
- Molecular Formula:
- C15H22Cl2N2
- Molecular Weight:
- 301.25458
- MDL Number:
- MFCD00209903
- MOL File:
- 138356-09-9.mol
BD 1008 Dihydrobromide price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 9001336 | BD 1008 (hydrobromide) ≥99% | 138356-09-9 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 9001336 | BD 1008 (hydrobromide) ≥99% | 138356-09-9 | 5mg | $74 | 2024-03-01 | Buy |
| Cayman Chemical | 9001336 | BD 1008 (hydrobromide) ≥99% | 138356-09-9 | 10mg | $122 | 2024-03-01 | Buy |
| Cayman Chemical | 9001336 | BD 1008 (hydrobromide) ≥99% | 138356-09-9 | 50mg | $547 | 2024-03-01 | Buy |
| TRC | B129450 | BD1008Dihydrobromide | 138356-09-9 | 10mg | $140 | 2021-12-16 | Buy |
BD 1008 Dihydrobromide Chemical Properties,Uses,Production
Uses
An α receptor antagonist, attenuating the biochemical effects of cocaine. Also studied was this compounds ability to prevent neuropathic pain following chemotherapy.
Biological Activity
bd 1008 dihydrobromide is a potent and selective ligand for σ-receptor with ki values of 2 and 8 nm for σ-1 receptor and σ-2 receptor, respectively [1].σ-receptor is a type of opioid receptor. there are two subtypes of σ-receptor: σ-1 and σ-2 [2].bd 1008 dihydrobromide is a potent and selective σ-receptor ligand. bd1008 showed high affinity to sites labeled by 4-[125i]pemp with ki value of 5.06 nm in guinea pig brain membranes. in mcf-7 breast cancer and melanoma (a375) cells, 4-[125i]pemp inhibited the binding of bd1008 with ki value of 11 nm in a dose-dependent way [2]. in xenopus oocytes coexpressed n-methyl-d-aspartate (nmda) receptor (nr) 1a with either nr2a, 2b or 2c, bd1008 inhibited nmda-activated membrane current responses with ic50 values of 62, 18 and 120 μm for nr1a/2a, nr1a/2b and nr1a/2c respectively, which were due to direct effects on the receptor channel complex [3].in mice, bd1008 (1 mg/kg) inhibited cocaine-induced locomotor activity with ed50 value increased from 6.50 mg/kg to 11.19 mg/kg [1].
References
[1]. mccracken ka, bowen wd, matsumoto rr. novel sigma receptor ligands attenuate the locomotor stimulatory effects of cocaine. eur j pharmacol, 1999, 365(1): 35-38.
[2]. john cs, gulden me, vilner bj, et al. synthesis, in vitro validation and in vivo pharmacokinetics of [125i]n-[2-(4-iodophenyl)ethyl]-n-methyl-2-(1-piperidinyl) ethylamine: a high-affinity ligand for imaging sigma receptor positive tumors. nucl med biol, 1996, 23(6): 761-766.
[3]. whittemore er, ilyin vi, woodward rm. antagonism of n-methyl-d-aspartate receptors by sigma site ligands: potency, subtype-selectivity and mechanisms of inhibition. j pharmacol exp ther, 1997, 282(1): 326-338.
BD 1008 Dihydrobromide Preparation Products And Raw materials
Raw materials
Preparation Products
BD 1008 Dihydrobromide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 94838 | 76 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15421 | 60 |
| Beijing Yisiyan Technology Research Center | 010-56645598 13366904824 | bjkaida@163.com | China | 1652 | 59 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8073 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55954 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |