MK-5108 (VX-689)
- CAS No.
- 1010085-13-8
- Chemical Name:
- MK-5108 (VX-689)
- Synonyms
- MK-5108;VX-689;CS-545;MK-5198;MK-5108(VX-689);MK-5108 (VX-689) USP/EP/BP;MK-5108 VX-689 Aurora Kinase Inhibitor;MK 5108; VX-689; VX 689; MK5108; VX689;trans-4-(3-Chloro-2-fluorophenoxy)-1-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]cyclohexanecarboxylic acid;4-(3-chloro-2-fluorophenoxy)-1-[[6-(1,3-thiazol-2-ylamino)pyridin-2-yl]methyl]cyclohexane-1-carboxylic acid
- CBNumber:
- CB62570376
- Molecular Formula:
- C22H21ClFN3O3S
- Molecular Weight:
- 461.94
- MDL Number:
- MFCD22124479
- MOL File:
- 1010085-13-8.mol
| Boiling point | 637.6±65.0 °C(Predicted) |
|---|---|
| Density | 1.429 |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | ≥23.1 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O |
| form | solid |
| pka | 4.41±0.44(Predicted) |
| FDA UNII | H8J407531S |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
MK-5108 (VX-689) price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19167 | MK-5108 ≥95% | 1010085-13-8 | 1mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 19167 | MK-5108 ≥95% | 1010085-13-8 | 5mg | $249 | 2024-03-01 | Buy |
| Cayman Chemical | 19167 | MK-5108 ≥95% | 1010085-13-8 | 10mg | $437 | 2024-03-01 | Buy |
| Usbiological | 474135 | MK 5108 | 1010085-13-8 | 100mg | $2442 | 2021-12-16 | Buy |
| TRC | M424995 | MK-5108 | 1010085-13-8 | 10mg | $150 | 2021-12-16 | Buy |
MK-5108 (VX-689) Chemical Properties,Uses,Production
Uses
MK-5108 is a highly selective Aurora-A kinase inhibitor that shows antitumor activity alone and in combination with Docetaxel (D494420).
Definition
ChEBI: 4-(3-chloro-2-fluorophenoxy)-1-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]-1-cyclohexanecarboxylic acid is an aromatic ether.
Biological Activity
mk-5108, also known as vx-689, is a novel, potent and selective inhibitor of aurora a kinase (aak) that competitively binds to the atp binding site of aak and hence potently inhibits the activity of aak with 50% inhibition concentration ic50 value of 0.064 nm. mk-5108 also inhibits other members of aurora kinase family, including aurora b kinase (ic50 = 14 nm) and aurora c kinase (ic50 = 12 nm), with a lesser potency. mk-5108 has been extensively studies and found to exhibit antitumor activity in a wide range of cancer types, including breast, cervix, colorectal, ovary and pancreas neoplasms.myke r. green, bs, pharm.d., bcop, joseph e. woolery, bs, pharm.d, and daruka mahadevan, md, phd. update on aurora kinase targeted therapeutics in oncology. recent pat anticancer drug discov. 2008 november ; 3(3): 162–177.
target
Aurora-A
MK-5108 (VX-689) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 27945 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |