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S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride

S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride structure

CAS No.: 86867-01-8

Chemical Name:: S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride

Synonyms: SAM; ADOMET;SAM chloride dihydrochloride;S-(5'-Adenosyl)-L-methionine chloride(SAM);-Adenosyl)-L-methionine chloride (hydrochloride);S-Adenosyl-L-methionine (chloride dihydrochloride);S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride;S-(5'-Adenosyl)-L-methionine chloride (hydrochloride);-Adenosyl)-L-methionine chloride dihydrochloride;S-(5'-Adenosyl)-L-methionine chloride dihydrochloride >=75%;5'-[[(3S)-3-Amino-3-carboxypropyl]methylsulfonio]-5'-deoxyadenosine chloride dihydrochloride

CBNumber:: CB62655576

Molecular Formula:: C15H24Cl2N6O5S

Molecular Weight:: 471.35

MDL Number:: MFCD22571809

MOL File:: 86867-01-8.mol

Last updated:2023-05-18 11:31:20

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S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride Properties

storage temp.	-20°C
solubility	H2O: soluble100mg/mL
form	A lyophilized powder
BRN	6560002

SAFETY

Risk and Safety Statements

Hazard Codes	Xn
Risk Statements	20/21/22-68/20/21/22
Safety Statements	36-45
WGK Germany	3

S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride price More Price(16)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	A7007	S-(5′-Adenosyl)-L-methionine chloride dihydrochloride ≥75%	86867-01-8	5mg	$70.3	2024-03-01	Buy
Sigma-Aldrich	A7007	S-(5′-Adenosyl)-L-methionine chloride dihydrochloride ≥75%	86867-01-8	1g	$1350	2024-03-01	Buy
Cayman Chemical	13956	S-(5'-Adenosyl)-L-methionine chloride (hydrochloride) ≥95%	86867-01-8	1mg	$41	2024-03-01	Buy
Cayman Chemical	13956	S-(5'-Adenosyl)-L-methionine chloride (hydrochloride) ≥95%	86867-01-8	2.5mg	$90	2024-03-01	Buy
Sigma-Aldrich	A7007	S-(5′-Adenosyl)-L-methionine chloride dihydrochloride ≥75%	86867-01-8	25mg	$91.8	2024-03-01	Buy

Product number	Packaging	Price	Buy
A7007	5mg	$70.3	Buy
A7007	1g	$1350	Buy
13956	1mg	$41	Buy
13956	2.5mg	$90	Buy
A7007	25mg	$91.8	Buy

S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride Chemical Properties,Uses,Production

Description

S-(5''-Adenosyl)-L-methionine chloride (SAM) is a ubiquitous methyl donor involved in a wide variety of biological reactions, including those mediated by DNA and protein methyltransferases. The transfer of a methyl group from SAM to an acceptor produces S-adenosyl-L-homocysteine . SAM is also metabolized by SAM decarboxlase to give decarboxylated SAM, which is involved in the polyamine pathway that generates spermine. Cayman Chemical’s SAM has been purified to remove all S-adenosylhomocysteine, a known inhibitor of most SAM-dependent methyltransferases which is commonly found in other commercially available SAM. In addition, Cayman’s SAM contains no S-methylthioadenosine, a common impurity which may act as a substrate in some assay formats, resulting in high background.

Uses

S-(5′-Adenosyl)-L-methionine chloride dihydrochloride has been used as a medium supplement for S30 cell extract. It also has been used for measuring the interaction with catechol-O-methyltransferase (COMT) by quartz crystal microbalance (QCM), surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC) with supported lipid bilayers and vesicles.

General Description

S-(5′-Adenosyl)-L-methionine chloride dihydrochloride (SAM) facilitates the transfer of methyl groups to proteins, lipids and nucleic acids. Methionine adenosyl transferase catalyses the synthesis of SAM from methionine and adenosine triphosphate (ATP). SAM functions to regulate various cellular functions like cell division, cell death, transcription, genetic stability, oxidant/antioxidant balance and polyamine homeostasis. Therapeutically, SAM finds its application as a nutritional supplement in humans for various diseases like osteoarthritis and liver injury. SAM also regulates transsulfuration reactions by binding to the regulatory domain of key enzyme cystathionine-β-synthase (CBS).

Biochem/physiol Actions

Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.

S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride Suppliers

Global( 49)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19743	58
NewCan Biotech Limited	+86-0571-86912261 +8613735419629	sales@newcanbio.com	China	9980	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19915	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
Hunan Hui Bai Shi Biotechnology Co., Ltd.	0731-85526065 13308475853	ivy@hnhbsj.com	China	4550	62
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-400-6206333 18521732826	market@aladdin-e.com	China	25014	65
Guangzhou Isun Pharmaceutical Co., Ltd	020-39119399 18927568969	isunpharm@qq.com	China	4428	55
Shanghai Macklin Biochemical Co.,Ltd.	15221275939 15221275939	shenlinxing@macklin.cn	China	15885	55

Supplier	Advantage
BOC Sciences	58
NewCan Biotech Limited	58
Nextpeptide Inc	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
LEAPCHEM CO., LTD.	58
Aladdin Scientific	58
Hunan Hui Bai Shi Biotechnology Co., Ltd.	62
Shanghai Aladdin Bio-Chem Technology Co.,LTD	65
Guangzhou Isun Pharmaceutical Co., Ltd	55
Shanghai Macklin Biochemical Co.,Ltd.	55

S-(5'-Adenosyl)-L-Methionine chloride dihydrochloride SAM chloride dihydrochloride 5'-[[(3S)-3-Amino-3-carboxypropyl]methylsulfonio]-5'-deoxyadenosine chloride dihydrochloride S-(5'-Adenosyl)-L-methionine chloride (hydrochloride) -Adenosyl)-L-methionine chloride dihydrochloride SAM; ADOMET S-(5'-Adenosyl)-L-methionine chloride(SAM) -Adenosyl)-L-methionine chloride (hydrochloride) S-(5'-Adenosyl)-L-methionine chloride dihydrochloride >=75% ((S)-3-Amino-3-carboxypropyl)(((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)(methyl)sulfonium chloride dihydrochloride [(3S)-3-amino-3-carboxypropyl]-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl]-methylsulfanium S-Adenosyl-L-methionine (chloride dihydrochloride) 86867-01-8 C15H23N6O5S2HClCl