2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro-
- CAS No.
- 1422955-31-4
- Chemical Name:
- 2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro-
- Synonyms
- HIF-C2;HIF-2α-I2;TC-S 7009;HIF-2 inhibitor 2;TCS 7009,TC S 7009;HIF-2 Antagonist 2;HIF-2α Antagonist 2;HIF Inhibitor VII - Calbiochem;N-(3-Chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine;2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro-
- CBNumber:
- CB62668459
- Molecular Formula:
- C12H6ClFN4O3
- Molecular Weight:
- 308.6524432
- MDL Number:
- MFCD25371546
- MOL File:
- 1422955-31-4.mol
- MSDS File:
- SDS
| Boiling point | 430.2±55.0 °C(Predicted) |
|---|---|
| Density | 1.652±0.06 g/cm3(Predicted) |
| storage temp. | room temp |
| solubility | DMSO: soluble15mg/mL, clear |
| form | Yellow powder |
| pka | -2.82±0.48(Predicted) |
| color | white to beige |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 1 month. |
2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro- price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0883 | HIF-2 Antagonist 2 ≥98% (HPLC) | 1422955-31-4 | 5mg | $118 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0883 | HIF-2 Antagonist 2 ≥98% (HPLC) | 1422955-31-4 | 25mg | $478 | 2024-03-01 | Buy |
| Sigma-Aldrich | 5.04379 | HIF Inhibitor VII - Calbiochem | 1422955-31-4 | 10MG | $265 | 2024-03-01 | Buy |
| Tocris | 5243 | TC-S7009 ≥99%(HPLC) | 1422955-31-4 | 5 | $87 | 2021-12-16 | Buy |
| Tocris | 5243 | TC-S7009 ≥99%(HPLC) | 1422955-31-4 | 25 | $324 | 2021-12-16 | Buy |
2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro- Chemical Properties,Uses,Production
Description
HIF-2α-I2 (1422955-31-4) is a potent and selective HIF-2α inhibitor, Kd=81 nM.1?Binds to the HIF-2α PAS-B domain2?and interferes with Hif-2α / ARNT heterodimerization reducing target gene expression in a cellular model1. Highly selective for HIF-2α displaying a >60-fold selectivity over HIF-1α.1,2
Uses
N-(3-Chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine is a HIF-2α inhibitor which inhibits HIF-2α-ARNT heterodimerization by binding to HIF-2α PAS-B domain. It may be used in therapeutic treatment of HIF-2-driven tumors such as renal cell carcinomas.
storage
Store at RT
References
1) Scheuermann?et al.?(2013),?Allosteric inhibition of hypoxia inducible factor-2 with small molecules; Nat. Chem. Biol.,?9?271 2) Masetti?et al.?(2014),?Protein dynamics of the HIF-2α PAS-B domain upon heterodimerization and ligand binding; PLoS One,?9(4)?e94986 3) Rodgers?et al.?(2013),?Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor; J. Med. Chem.,?56 1739
2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro- Preparation Products And Raw materials
Raw materials
Preparation Products
2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro- Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |
| AdooQ Bioscience CHINA | 025-58849295 18951903616; | info@adooq.cn | China | 2989 | 60 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9254 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3500 | 55 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |