GSK484
- CAS No.
- 1652591-81-5
- Chemical Name:
- GSK484
- Synonyms
- GSK484;CS-2265;AOB6992;GTPL8577;GSK484 HCl;GSK484 >=98% (HPLC);PAD4 inhibitor GS484;PAD4 inhibitor GSK484;GSK484 (hydrochloride);GSK484 hydrochloride,GSK 484,Protein Arginine Deiminase,GSK-484,GSK-484 hydrochloride,GSK484,inhibit,Peptidylarginine Deiminase,Inhibitor
- CBNumber:
- CB63146499
- Molecular Formula:
- C27H32ClN5O3
- Molecular Weight:
- 510.04
- MDL Number:
- MOL File:
- 1652591-81-5.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
HS Code | 2933399990 |
GSK484 price More Price(21)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML1658 | GSK484 ≥98% (HPLC) | 1652591-81-5 | 5MG | $346 | 2023-06-20 | Buy |
Sigma-Aldrich | SML1658 | GSK484 ≥98% (HPLC) | 1652591-81-5 | 25MG | $1350 | 2023-06-20 | Buy |
Cayman Chemical | 17488 | GSK484 (hydrochloride) ≥95% | 1652591-81-5 | 500μg | $37 | 2024-03-01 | Buy |
Cayman Chemical | 17488 | GSK484 (hydrochloride) ≥95% | 1652591-81-5 | 1mg | $68 | 2024-03-01 | Buy |
Cayman Chemical | 17488 | GSK484 (hydrochloride) ≥95% | 1652591-81-5 | 5mg | $283 | 2024-03-01 | Buy |
GSK484 Chemical Properties,Uses,Production
Description
GSK484 is a reversible inhibitor of PAD4 (IC50 = 50 nM) that binds to the low-calcium form of the enzyme. It is selective for PAD4 over PAD1-3. GSK484 blocks the citrullination of PAD4 target proteins in human neutrophils and inhibits the formation of neutrophil extracellular traps in both mouse and human neutrophils. It exhibits favorable pharmacokinetic profiles in mouse and rat. See the Structural Genomics Consortium (SGC) website for more information.
Uses
GSK484 is a novel selective PAD4 inhibitor.
Biochem/physiol Actions
GSK484 is a potent selective reversible inhibitor of protein arginine deiminase PAD4, an enzyme believed to play a role in granulocyte and macrophage development leading to inflammation and immune response, and overexpressed in many tumors. GSK484 has IC50 values of 50 nM without calcium and 250 nM in the presence of 2 mM calcium. GSK484 showed minimal off-target activity tested against 50 other proteins with no activation across HDACs 1–11 even at 100 μM. GSK484 binds at a different site from the amidines, a conformation of the PAD4 active site where part of the site is reordered to form a β-hairpin. For full characterization details, please visit the GSK484 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
GSK484 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hubei Chuchang Biotech Co., Ltd. | +86-18727130788 +86-18727130788 | info@chuchangbiotech.com | China | 102 | 58 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
Hebei Miaoyin Technology Co.,Ltd | +86-17367732028 +86-17367732028 | kathy@hbyinsheng.com | China | 3582 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
View Lastest Price from GSK484 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-06-06 | GSK484 (hydrochloride)
1652591-81-5
|
US $0.00-0.00 / mg | 1mg | 98% | 100G | Hubei Chuchang Biotech Co., Ltd. |
- GSK484 (hydrochloride)
1652591-81-5
- US $0.00-0.00 / mg
- 98%
- Hubei Chuchang Biotech Co., Ltd.
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