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NVS-PAK1-1

NVS-PAK1-1 Structure
NVS-PAK1-1 structure
CAS No.
1783816-74-9
Chemical Name:
NVS-PAK1-1
Synonyms
NVS-PAK1-1;NVS-PAK11Chemicalbook;NVS-PAK1-1 >=98% (HPLC);NVS-PAK1-1;NVS-PAK11;NVS-PAK1 1;Inhibitor,p21 activated kinases,NVS PAK1 1,inhibit,PAK,NVS-PAK-1-1,NVSPAK11;(3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N-isopropylpyrrolidine-1-carboxamide;(S)-3-((2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-yl)amino)-N-isopropylpyrrolidine-1-carboxamide;1-Pyrrolidinecarboxamide, 3-[[2-chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-yl]amino]-N-(1-methylethyl)-, (3S)-
CBNumber:
CB63333615
Molecular Formula:
C23H25ClF3N5O
Molecular Weight:
479.93
MDL Number:
MFCD30723183
MOL File:
1783816-74-9.mol
MSDS File:
SDS
Last updated:2023-06-30 15:45:59
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NVS-PAK1-1 Properties

Boiling point 697.8±55.0 °C(Predicted)
Density 1.42±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMF: 50 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 50 mg/ml; Ethanol: 20 mg/ml
pka 14.02±0.40(Predicted)
form powder
color white to beige

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313

NVS-PAK1-1 price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SML1867 NVS-PAK1-1 ≥98% (HPLC) 1783816-74-9 5MG $155 2023-06-20 Buy
Sigma-Aldrich SML1867 NVS-PAK1-1 ≥98% (HPLC) 1783816-74-9 25MG $618 2023-06-20 Buy
Cayman Chemical 19964 NVS-PAK1-1 ≥98% 1783816-74-9 5mg $121 2024-03-01 Buy
Cayman Chemical 19964 NVS-PAK1-1 ≥98% 1783816-74-9 10mg $218 2024-03-01 Buy
Cayman Chemical 19964 NVS-PAK1-1 ≥98% 1783816-74-9 25mg $481 2024-03-01 Buy
Product number Packaging Price Buy
SML1867 5MG $155 Buy
SML1867 25MG $618 Buy
19964 5mg $121 Buy
19964 10mg $218 Buy
19964 25mg $481 Buy

NVS-PAK1-1 Chemical Properties,Uses,Production

Uses

NVS PAK1 1 is one of potent and selective allosteric PAK1 inhibitors.

Biochem/physiol Actions

NVS-PAK1-1 is a potent allosteric inhibitor of p21-activated kinase PAK1, a serine-threonine kinase that is upregulated in many cancers. NVS-PAK1-1 has an IC50 value of 5 nM for dephoshorylated PAK1 and 6 nM for phosphorylated PAK1 in an in vitro dephosphorylation assay. NVS-PAK1-1 showed good selectivity against 442 other kinases including PAK2. NVS-PAK1-1 has generally good physicochemical properties, but was metabolized by rat liver microsomes, so may not be useful for in vivo work. For full characterization details, please visit the NVS-PAK1-1 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for protein targets, visit sigma.com/sgc

storage

Store at -20°C

NVS-PAK1-1 Preparation Products And Raw materials

Raw materials

Preparation Products

NVS-PAK1-1 Suppliers

Global( 63)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32686 60
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19553 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
Aladdin Scientific 		+1-833-552-7181 sales@aladdinsci.com United States 57511 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139 orders@jknbiochem.com China 4664 58
Chengdu Henghui Pharm Tec Co. Ltd. 13540674322 15828370308 CHINA 121 55
Chengdu Celes Technology Co., Ltd 17323066073 2538834896@qq.com China 80 58
Deyang Sino Biotech. Co., LTD 19182167371 19182167371 service@synlord.com China 93 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
BOC Sciences 		58
TargetMol Chemicals Inc. 		58
InvivoChem 		58
Aladdin Scientific 		58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		58
Chengdu Henghui Pharm Tec Co. Ltd. 55
Chengdu Celes Technology Co., Ltd 58
Deyang Sino Biotech. Co., LTD 58
Sigma-Aldrich 80

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1of2

NVS-PAK1-1 (3S)-3-(2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-ylamino)-N-isopropylpyrrolidine-1-carboxamide NVS-PAK1-1;NVS-PAK11;NVS-PAK1 1 1-Pyrrolidinecarboxamide, 3-[[2-chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-yl]amino]-N-(1-methylethyl)-, (3S)- NVS-PAK1-1 >=98% (HPLC) NVS-PAK11Chemicalbook (S)-3-((2-Chloro-5-(2,2-difluoroethyl)-8-fluoro-5H-dibenzo[b,e][1,4]diazepin-11-yl)amino)-N-isopropylpyrrolidine-1-carboxamide Inhibitor,p21 activated kinases,NVS PAK1 1,inhibit,PAK,NVS-PAK-1-1,NVSPAK11 1783816-74-9 API