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N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE

CAS No.
261766-23-8
Chemical Name:
N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE
Synonyms
N-4AIA;N-4ACETIA;N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE;N-(4-ACETAMIDOPHENYL)-1-P-CHLOROBENZOYL-5-METHOXY-2-METHYLINDOLE-3-ACETAMIDE;N-(4-ACETAMIDOPHENYL)-1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETAMIDE;1H-Indole-3-acetamide, N-[4-(acetylamino)phenyl]-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-;N-4AcetIA, N-(4-Acetamidophenyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetamide
CBNumber:
CB6475024
Molecular Formula:
C27H24ClN3O4
Molecular Weight:
489.95
MDL Number:
MFCD02683236
MOL File:
Mol file
Last updated:2023-05-18 11:31:03

N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE Properties

Melting point 256-257°C
storage temp. −20°C
solubility DMSO: ≥15 mg/mL
form crystalline
color Pale Yellow

SAFETY

Risk and Safety Statements

WGK Germany  3

N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 70278 N-(4-acetamidophenyl)-Indomethacin amide ≥98% 261766-23-8 1mg $18 2024-03-01 Buy
Cayman Chemical 70278 N-(4-acetamidophenyl)-Indomethacin amide ≥98% 261766-23-8 5mg $73 2024-03-01 Buy
Cayman Chemical 70278 N-(4-acetamidophenyl)-Indomethacin amide ≥98% 261766-23-8 10mg $129 2024-03-01 Buy
Cayman Chemical 70278 N-(4-acetamidophenyl)-Indomethacin amide ≥98% 261766-23-8 50mg $553 2024-03-01 Buy
TRC A161150 N-(4-Acetamidophenyl)indomethacinAmide 261766-23-8 5mg $55 2021-12-16 Buy
Product number Packaging Price Buy
70278 1mg $18 Buy
70278 5mg $73 Buy
70278 10mg $129 Buy
70278 50mg $553 Buy
A161150 5mg $55 Buy

N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE Chemical Properties,Uses,Production

Description

N-(4-acetamidophenyl)-indomethacin amide (N-4-AIA) is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2. N-4-AIA inhibits human recombinant and ovine COX-2 with IC50 values of 0.12 and 0.625 μM, respectively. It is about 400 times less potent as an inhibitor of human recombinant COX-1 and 80 times less potent as an inhibitor of ovine COX-1 than ovine COX-2.

Chemical Properties

Pale Yellow Solid

Uses

An aromatic amide of indomethacin recently reported to be a potent and selective reversible inhibitor of COX-2. Inhibits human recombinant and ovine COX-2 with IC50 of 0.1 uM and 0.625 uM, respectively

Definition

ChEBI: N-(4-acetamidophenyl)-Indomethacin amide is a N-acylindole.

References

[1]. kalgutkar as, marnett ab, crews bc, et al. ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. j med chem. 2000 jul 27;43(15):2860-70.

N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE Suppliers

Global( 21)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 94838 76
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
Chemsky(shanghai)International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32344 50
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969 isunpharm@qq.com China 4428 55
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 13028896684 sales@rrkchem.com China 55954 58
Energy Chemical 021-58432009 400-005-6266 marketing1@energy-chemical.com China 44843 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8141 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8740 58
United States Biological -- sales@advtechind.com United States 6106 58
Carbosynth -- sales@carbosynth.com United Kingdom 6018 58

261766-23-8(N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE)Related Search:

N-(4-ACETAMIDOPHENYL)-1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETAMIDE N-(4-ACETAMIDOPHENYL)-1-P-CHLOROBENZOYL-5-METHOXY-2-METHYLINDOLE-3-ACETAMIDE N-(4-ACETAMIDOPHENYL)-INDOMETHACIN AMIDE N-4ACETIA N-4AIA N-4AcetIA, N-(4-Acetamidophenyl)-1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetamide 1H-Indole-3-acetamide, N-[4-(acetylamino)phenyl]-1-(4-chlorobenzoyl)-5-methoxy-2-methyl- 261766-23-8 C27H24N3O4Cl C27H24ClN3O4 Biochemicals and Reagents BioChemical Application Index Cell Signaling Enzymes Cyclooxygenase Inhibitors Cyclooxygenase (COX) Enzymes Enzymes, Inhibitors, and Substrates Inhibitors Aromatics Heterocycles