Methoxycarbonyl-L-tert-leucine
- CAS No.
- 162537-11-3
- Chemical Name:
- Methoxycarbonyl-L-tert-leucine
- Synonyms
- (S)-2-acetamido-3,3-dimethylbutanoic acid;MOC-L-tert.Leucine;N-Methoxycarbonyl-tert-leucine;(S)-2-(MethoxycarbonylaMino)-3,3-diMethylbutanoic acid;Moc-L-tle;Moc-Tle-OH;MOC-L-Norleucine;Moc-L-tert-lecine;MOC-L-tert. Leucin;Atazanavir USP RC A
- CBNumber:
- CB6663762
- Molecular Formula:
- C8H15NO4
- Molecular Weight:
- 189.21
- MDL Number:
- MFCD07778455
- MOL File:
- 162537-11-3.mol
Melting point | 1090C |
---|---|
Boiling point | 320.9±25.0 °C(Predicted) |
Density | 1.126±0.06 g/cm3(Predicted) |
vapor pressure | 0Pa at 25℃ |
storage temp. | 2-8°C |
solubility | Soluble in ethyl acetate and methanol. |
pka | 4.46±0.10(Predicted) |
form | powder |
Water Solubility | 26.4g/L at 20℃ |
InChI | InChI=1S/C8H15NO4/c1-8(2,3)5(6(10)11)9-7(12)13-4/h5H,1-4H3,(H,9,12)(H,10,11)/t5-/m1/s1 |
InChIKey | NWPRXAIYBULIEI-RXMQYKEDSA-N |
SMILES | C(O)(=O)[C@H](C(C)(C)C)NC(OC)=O |
LogP | 0.832 at 21℃ |
FDA UNII | 0L7G8ZHR2P |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
HS Code | 2933399090 | |||||||||
NFPA 704 |
|
Methoxycarbonyl-L-tert-leucine price More Price(34)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | PHR3001 | Atazanavir Related Compound A pharmaceutical secondary standard, certified reference material | 162537-11-3 | 50MG | $461 | 2024-03-01 | Buy |
Sigma-Aldrich | 1044356 | Atazanavir Related Compound A United States Pharmacopeia (USP) Reference Standard | 162537-11-3 | 25mg | $1210 | 2024-03-01 | Buy |
Alfa Aesar | H35148 | N-Methoxycarbonyl-L-tert-leucine, 98% | 162537-11-3 | 5g | $147 | 2021-12-16 | Buy |
Alfa Aesar | H35148 | N-Methoxycarbonyl-L-tert-leucine, 98% | 162537-11-3 | 1g | $37.3 | 2021-12-16 | Buy |
Alfa Aesar | H35148 | N-Methoxycarbonyl-L-tert-leucine, 98% | 162537-11-3 | 25g | $593 | 2021-12-16 | Buy |
Methoxycarbonyl-L-tert-leucine Chemical Properties,Uses,Production
Description
Methoxycarbonyl-L-tert-leucine is a kind of amino acid deriviative. It is a very useful intermediate for efficient synthesis of the HIV protease inhibitor BMS-232632 as well as atazanavir bisulfate.
References
Zhongmin Xu, †, et al. "Process Research and Development for an Efficient Synthesis of the HIV Protease Inhibitor BMS-232632." Organic Process Research & Development 6.3(2002):323-328.
Simhadri, Srinivas. "Process for the preparation of atazanavir bisulfate." (2016).
https://www.alfa.com/en/search/?q=14328-63-3
Chemical Properties
White Solid
Uses
The coupling of the two key intermediates, N-(methoxycarbonyl)-l-tert-leucine acylated benzyl hydrazine and chloromethyl ketone, via an S N 2 reaction furnished the amino ketone in high yield under our optimized conditions in practical synthesis of the HIV Protease Inhibitor Atazanavir via a Highly diastereoselective Reduction Approach.
Flammability and Explosibility
Not classified
Methoxycarbonyl-L-tert-leucine Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
weifang runzhong fine chemical co., ltd | 536-7868377 +8618653686003 | sq@runzhongchem.com | China | 187 | 58 |
Zhejiang ZETian Fine Chemicals Co. LTD | 18957127338 | stella@zetchem.com | China | 2141 | 58 |
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 994 | 58 |
Chongqing Zhihe Biopharmaceutical Co., Ltd. | +86-18580541567 +86-17782035140 | sales@zhswyy.com | China | 326 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 19368 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 15954 | 58 |
Taizhou Tianhong Biochemistry Technology Co., Ltd. | 0523-86132544 | sales@thbiochem.com | CHINA | 305 | 60 |
View Lastest Price from Methoxycarbonyl-L-tert-leucine manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-05-30 | Methoxycarbonyl-L-tert-leucine
162537-11-3
|
US $0.00-0.00 / kg | 0.10000000149011612kg | 99 | 20tons | Chongqing Zhihe Biopharmaceutical Co., Ltd. | ||
2024-05-21 | N-Methoxycarbonyl-L-tert-Leucine
162537-11-3
|
US $0.00 / kg | 1kg | 99% | 20tons | Shanghai Joiny Pharmaceutical Co.,LTD | ||
2024-05-10 | Methoxycarbonyl-L-tert-leucine
162537-11-3
|
US $60.00-600.00 / KG | 1KG | 0.99 | 20 tons | Zibo Hangyu Biotechnology Development Co., Ltd |
- Methoxycarbonyl-L-tert-leucine
162537-11-3
- US $0.00-0.00 / kg
- 99
- Chongqing Zhihe Biopharmaceutical Co., Ltd.
- N-Methoxycarbonyl-L-tert-Leucine
162537-11-3
- US $0.00 / kg
- 99%
- Shanghai Joiny Pharmaceutical Co.,LTD
- Methoxycarbonyl-L-tert-leucine
162537-11-3
- US $60.00-600.00 / KG
- 0.99
- Zibo Hangyu Biotechnology Development Co., Ltd