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levomethorphan

CAS No.
125-70-2
Chemical Name:
levomethorphan
Synonyms
l-Methorphan;Levomethorphanum;Dextromethorphan Impurity 18 HCl;Levomethorphan (1.0mg/ml in Acetonitrile);Morphinan, 3-methoxy-17-methyl- (8CI, 9CI);Dextromethorphan Impurity 6(Levomethorphan);Levomethorphan (dextromethorphan impurity 23);2H-10,4a-Iminoethanophenanthrene, 1,3,4,9,10,10a-hexahydro-6-methoxy-11-methyl- (6CI)
CBNumber:
CB6925105
Molecular Formula:
C18H25NO
Molecular Weight:
271.4
MDL Number:
MFCD00866833
MOL File:
125-70-2.mol
Last updated:2023-05-15 10:43:25

levomethorphan Properties

storage temp. 2-8°C
solubility Chloroform (Slightly), Ethanol (Slightly), Methanol (Sparingly)
Boiling point 394.9±42.0 °C(Predicted)
Density 1.11±0.1 g/cm3(Predicted)
Melting point 81-83 °C
pka 9.13±0.20(Predicted)
FDA UNII 7ZZ22K9QE6

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P501
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
HS Code  2933492250
Toxicity mouse,LD50,subcutaneous,78mg/kg (78mg/kg),British Journal of Pharmacology and Chemotherapy. Vol. 17, Pg. 433, 1961.

levomethorphan Chemical Properties,Uses,Production

Uses

The enatiomer of Dextromethorphan (D299455), an antitussive medicine, a narcotic.

Definition

ChEBI: Levomethorphan is a 6-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthrene in which the stereocenters at positions 4a, 10 and 10a have R-configuration. It is a prodrug of levorphanol and a strong narcotic analgesic, and listed as a schedule II controlled substance. It has a role as an opioid analgesic and a prodrug. It is functionally related to a Levorphanol. It is an enantiomer of a dextromethorphan.

levomethorphan Preparation Products And Raw materials

Raw materials

Preparation Products

Levomethorphanum 2H-10,4a-Iminoethanophenanthrene, 1,3,4,9,10,10a-hexahydro-6-methoxy-11-methyl- (6CI) l-Methorphan Morphinan, 3-methoxy-17-methyl- (8CI, 9CI) Levomethorphan (1.0mg/ml in Acetonitrile) Dextromethorphan Impurity 18 HCl Dextromethorphan Impurity 6(Levomethorphan) Levomethorphan (dextromethorphan impurity 23) 125-70-2 Aromatics Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals