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5-Dehydro Tolvaptan

5-Dehydro Tolvaptan Structure
5-Dehydro Tolvaptan structure
CAS No.
137973-76-3
Chemical Name:
5-Dehydro Tolvaptan
Synonyms
Dehydrotolvaptan;5-Dehydro Tolvaptan;Tolvaptan Intermediate;Tolvaptan 5-Oxo Analog;Tolvaptan impurity 5 (DM-21826);7-chloro-1-[2-methyl-4-[(2-methylbenzoyl)amino]benzoyl]-5-ox...;N-(4-(7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methy;N-[4-(7-chloro-5-oxo-3,4-dihydro-2H-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide;N-(4-(7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbe;7-chloro-1-[2-methyl-4-[(2-methylbenzoyl)amino]benzoyl]-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine
CBNumber:
CB72500620
Molecular Formula:
C26H23ClN2O3
Molecular Weight:
446.93
MDL Number:
MFCD19440797
MOL File:
137973-76-3.mol
MSDS File:
SDS
Last updated:2024-03-07 09:17:34
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5-Dehydro Tolvaptan Properties

Melting point >118°C (dec.)
Boiling point 593.2±50.0 °C(Predicted)
Density 1.307
storage temp. Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka 12.97±0.70(Predicted)
color White to Off-White
InChIKey VENGMROMZOKURN-UHFFFAOYSA-N
SMILES C(NC1=CC=C(C(N2C3=CC=C(Cl)C=C3C(=O)CCC2)=O)C(C)=C1)(=O)C1=CC=CC=C1C
FDA UNII YR22W5RA83

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H413
Precautionary statements  P501-P273-P270-P264-P301+P312+P330

5-Dehydro Tolvaptan price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC D230350 5-DehydroTolvaptan 137973-76-3 50mg $1190 2021-12-16 Buy
Matrix Scientific 096805 N-(4-(7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbenzamide 95+% 137973-76-3 1g $1647 2021-12-16 Buy
Medical Isotopes, Inc. 56358 5-DehydroTolvaptan 137973-76-3 50mg $2200 2021-12-16 Buy
Biosynth Carbosynth FC151485 N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-oxo-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide 137973-76-3 2mg $59 2021-12-16 Buy
Biosynth Carbosynth FC151485 N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-oxo-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide 137973-76-3 50mg $704 2021-12-16 Buy
Product number Packaging Price Buy
D230350 50mg $1190 Buy
096805 1g $1647 Buy
56358 50mg $2200 Buy
FC151485 2mg $59 Buy
FC151485 50mg $704 Buy

5-Dehydro Tolvaptan Chemical Properties,Uses,Production

Uses

5-Dehydro Tolvaptan is an impurity of Tolvaptan (T536650), a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH g

Preparation

To a 3 L reactor was added 1- (4-amino-2-methylbenzoyl) -7-chloro-5-oxo-2,3,4,5-tetrahydro- 1 H- 1 -benzazepine (70. 0 g, 212.90 mmol), dichloromethane (560 ml) and distilled water (140 ml), and the mixture was stirred for 1 hour. Magnesium hydroxide (14.90 g, 14.90 mmol) was added to the reaction mixture at 10 ° C. or lower, and the mixture was stirred for 30 minutes. 2-Methylbenzoyl chloride (30.42 ml) was gradually added to the reaction mixture, stirring for 3 hours. The reaction mixture was filtered to remove magnesium hydroxide, and the pH of the reaction mixture was adjusted to pH 8 to 9 using an aqueous sodium hydroxide solution, and then the organic layer was separated. The obtained organic layer was dried with sodium sulfate (Na 2 SO 4), filtered, and concentrated under reduced pressure to give 5-Dehydro Tolvaptan (yield: 96 percent).

5-Dehydro Tolvaptan Preparation Products And Raw materials

Raw materials

N-(4-bromo-3-methylphenyl)-2-methylbenzamide 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one 2-Methyl-4-(2-methylbenzamido)benzoic acid carbon monoxide

Preparation Products

5-Dehydro Tolvaptan Suppliers

Global( 137)Suppliers
Supplier Tel Email Country ProdList Advantage
Enki Biopharmaceuticals (Shanghai) Limited
+86-0086-2157680326 +8613916707528 yusu@enkibiopharma.com China 46 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15954 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21687 55
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3012 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Cangzhou Wanyou New Material Technology Co.,Ltd 		18631714998 sales@czwytech.com CHINA 906 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14336 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39916 58
Supplier Advantage
Enki Biopharmaceuticals (Shanghai) Limited
58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
career henan chemical co 		58
Cangzhou Wanyou New Material Technology Co.,Ltd 		58
Standardpharm Co. Ltd. 		58
Chongqing Chemdad Co., Ltd 		58

View Lastest Price from 5-Dehydro Tolvaptan manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Tolvaptan Intermediate pictures 2019-08-05 Tolvaptan Intermediate
137973-76-3
 US $1.00 / g 1g 99% 5 tons Cangzhou Wanyou New Material Technology Co.,Ltd
N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-oxo-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide pictures 2019-07-06 N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-oxo-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide
137973-76-3
 US $2.00 / kg 1kg 99% Ask Career Henan Chemical Co

137973-76-3(5-Dehydro Tolvaptan)Related Search:

(R)-(+)-Tolvaptan Ethyl 7-Chloro-5-oxo-1-toxyl-2,3,4,5,-tetrahydro-1H-benzo[b]azepine-4-carboxylate Tolvaptan Impurity 18 Tolvaptan Impurity 13 5-Chloro-2-[(4-ethoxy-4-oxobutyl)[(4-methylphenyl)sulfonyl]amino]benzoic acid methyl ester
Tolvaptan Impurity 21 Tolvaptan Impurity 3 (DM-4104) Tolvaptan Impurity 30 7-Chloro-1,2,3,4-tetrahydro-1-[(4-methylphenyl)sulfonyl]-5H-1-benzazepin-5-one Tolvaptan Impurity 17
Tolvaptan impurity 2 Tolvaptan Impurity 20 Tolvaptan Impurity 15 Tolvaptan Impurity 11 Tolvaptan Impurity 26
Tolvaptan 7-Chloro-1,2,3,4-tetrahydrobenzo(b)azepin-5-one 7-Chloro-1,2,3,4-tetrahydro-1-(2-methyl-4-nitrobenzoyl)-5H-1-benzazepin-5-one

1of4

N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-oxo-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide 7-chloro-1-[2-methyl-4-[(2-methylbenzoyl)amino]benzoyl]-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine N-(4-(7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methylbe 5-Dehydro Tolvaptan N-(4-(7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-Methylphenyl)-2-MethylbenzaMide Dehydrotolvaptan N-[4-[7-Chloro-2,3,4,5-Tetrahydro-5-oxo-1H-1-Benzazepine-1-yl)carbonyl]-3-MethylPhenyl]-2-MethylBenzamide N-[4-(7-chloro-5-oxo-3,4-dihydro-2H-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide N-(4-(7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepine-1-carbonyl)-3-methylphenyl)-2-methy Tolvaptan Intermediate Tolvaptan impurity 5 (DM-21826) Tolvaptan 5-Oxo Analog Benzamide, N-[4-[(7-chloro-2,3,4,5-tetrahydro-5-oxo-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methyl- N-[4-(7-chloro-5-oxo-2,3,4,5-tetrahydro-1H-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide 7-chloro-1-[2-methyl-4-[(2-methylbenzoyl)amino]benzoyl]-5-ox... N-[4-[(7- chloro -2,3,4,5- tetrahydro -5- oxo -1H-1- benzoazepine -1- yl) carbonyl ]-3- methylphenyl ]-2- methylbenzamide * N-[4-[(7-Chloro-5-oxo-2,3,4,5-tetrahydro-1H-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide 137973-76-3 Tolvaptan intermediate