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CAY10581

CAY10581 Structure
CAY10581 structure
CAS No.
1018340-07-2
Chemical Name:
CAY10581
Synonyms
CAY10581;CAY10581 Exclusive;2H-Naphtho[2,3-b]pyran-5,10-dione, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-[(phenylmethyl)amino]-, (3R,4R)-rel-
CBNumber:
CB72590430
Molecular Formula:
C22H21NO4
Molecular Weight:
363.41
MDL Number:
MFCD18428034
MOL File:
1018340-07-2.mol
Last updated:2023-04-23 13:52:06
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CAY10581 Properties

Boiling point 548.8±50.0 °C(Predicted)
Density 1.32±0.1 g/cm3(Predicted)
solubility DMF: 10 mg/ml; DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml; DMSO: 3 mg/ml
form A crystalline solid
pka 12.53±0.60(Predicted)

CAY10581 price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 16838 CAY10581 ≥97% 1018340-07-2 1mg $37 2024-03-01 Buy
Cayman Chemical 16838 CAY10581 ≥97% 1018340-07-2 5mg $161 2024-03-01 Buy
Cayman Chemical 16838 CAY10581 ≥97% 1018340-07-2 10mg $283 2024-03-01 Buy
Cayman Chemical 16838 CAY10581 ≥97% 1018340-07-2 25mg $618 2024-03-01 Buy
Product number Packaging Price Buy
16838 1mg $37 Buy
16838 5mg $161 Buy
16838 10mg $283 Buy
16838 25mg $618 Buy

CAY10581 Chemical Properties,Uses,Production

Description

The enzyme indoleamine 2,3-dioxygenase (IDO) has been implicated in mediating pathological immunosuppression associated with certain diseases, including cancer. Several naphthoquinones inhibit IDO in vitro and in cells, but at low (μM) potency. Importantly, naphthoquinones reduce tumor growth in wild type mice but not in IDO-deficient mice. CAY10581 is a naphthoquinone derivative that potently inhibits IDO (IC50 = 55 nM). It is a more potent inhibitor of IDO than annulin B or 1-methyl-d-tryptophan (1MT). CAY10581 acts as a reversible uncompetitive inhibitor of IDO and demonstrates minimal impact on cell viability at 100 μM after 24 hours.

Uses

CAY10581 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor.

CAY10581 Preparation Products And Raw materials

Raw materials

Preparation Products

CAY10581 Suppliers

Global( 25)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Energy Chemical 021-58432009 400-005-6266 marketing1@energy-chemical.com China 44843 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8740 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.com China 24246 58
Supplier Advantage
Aladdin Scientific 		58
Shanghai Hongye Biotechnology Co. Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Energy Chemical 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58
CAY10581 CAY10581 Exclusive 2H-Naphtho[2,3-b]pyran-5,10-dione, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-[(phenylmethyl)amino]-, (3R,4R)-rel- 1018340-07-2