Losartan | 114798-26-4

Losartan Properties

Melting point	183-184 C
Boiling point	682.0±65.0 °C(Predicted)
Density	1.35±0.1 g/cm3(Predicted)
vapor pressure	0.002Pa at 20℃
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	5-6(at 25℃)
color	White to Off-White
Water Solubility	4.8mg/L at 20℃
LogP	1.1 at 20℃
CAS DataBase Reference	114798-26-4(CAS DataBase Reference)
FDA UNII	JMS50MPO89
ATC code	C09CA01
EPA Substance Registry System	1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- (114798-26-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS08
Signal word	Danger
Hazard statements	H317-H360FD-H362
Precautionary statements	P202-P260-P263-P280-P302+P352-P308+P313
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36

Losartan price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	L470470	Losartan	114798-26-4	500mg	$385	2021-12-16	Buy
Biorbyt Ltd	orb134724	Losartan >99%	114798-26-4	1g	$606.9	2021-12-16	Buy
Medical Isotopes, Inc.	D34052	Losartan-d6HCl	114798-26-4	5mg	$1500	2021-12-16	Buy
ChemScene	CS-2116	Losartan 99.55%	114798-26-4	500mg	$50	2021-12-16	Buy
Biosynth Carbosynth	BL164640	Losartan	114798-26-4	100mg	$50	2021-12-16	Buy

Product number	Packaging	Price	Buy
L470470	500mg	$385	Buy
orb134724	1g	$606.9	Buy
D34052	5mg	$1500	Buy
CS-2116	500mg	$50	Buy
BL164640	100mg	$50	Buy

Losartan Chemical Properties,Uses,Production

Originator

Alsartan, Aristo Pharmaceutical Ltd., India

Uses

Losartan is a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.

Uses

antihypertensive;antagonist of angiotensin type 1

Definition

ChEBI: A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position

Manufacturing Process

2-Butyl-4-chloro-1-(2'-(tetrazol-5-yl)biphenyl-4-ylmethyl)-1H-imidazole-5- methanolpotassium was synthesized in 5 stages.
1. Methyl 4'-methylbiphenyl-2-carboxylate (44.2 mmol), 0.5 N KOH in methanol (133 mmol), and water (50 mL) were mixed and refluxed under nitrogen. After 5 hours, the solvent was removed in vacuo and water (200 mL) and ethyl acetate (200 mL) added. The aqueous layer was acidified with concentrated hydrochloric acid to a pH of 3 and the layers were separated. The aqueous phase was extracted with ethyl acetate, the organic layers collected, dried (MgSO4) and the solvent removed in vacuo to yield 8.71 g of a 4'-methylbiphenyl-2-carboxylic acid, melting point 140.0-145.0°C.
2. 4'-Methylbiphenyl-2-carboxylic acid (41 mmol) and thionyl chloride (411 mmol) were mixed and refluxed for 2 hours. The excess thionyl chloride was removed in vacuo and the residue was taken up in toluene. The toluene was removed by rotary evaporation. The crude acid chloride was then added slowly to cold (0°C) concentrated NH4OH (50 mL) so that the temperature was kept below 15°C. After 15 minutes of stirring, water (100 mL) was added and solids precipitated. These were collected, washed with water and dried under high vacuum over P2O5 to yield 7.45 g of a white solid, melting point 126.0-128.5°C. The above product amide (35 mmol) and thionyl chloride (353 mmol) were mixed and refluxed for 3 hours. The thionyl chloride was removed using the same procedure as described above. The residue was washed with a little hexane to yield 6.64 g of 4'-methyl-2-cyanobiphenyl, melting point 44.0- 47.0°C.
3. 4'-Methyl-2-cyanobiphenyl (5.59 g) was brominated using benzoyl peroxide as an initiator. The product was recrystallized from ether to yield 4.7 g of 4'- bromomethyl-2-cyanobiphenyl, melting point 114.5-120.0°C.
4. 4'-Bromomethyl-2-cyanobiphenyl (4.6 g) was alkylated onto 2-n-butyl-4- chloro-5-(hydroxymethyl)-imidazole. For separation of the product was used a flash chromatography in 1:1 hexane/ethyl acetate over silica gel. The regioisomeric products yielded 2.53 g of the faster eluting isomer. Recrystallization from acetonitrile yielded 1.57 g of analytically pure 2-n-butyl4-chloro-1-[2'-cyanobiphenyl-4-yl)methyl]-5-(hydroxymethyl)-imidazole, melting point 153.5 -155.5°C.
5. 2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)- imidazole (10 mmole), sodium azide (10 mmol), and ammonium chloride (30 mmol) were mixed in DMF (150 mL) under N2 at 100°C for 2 days, after which the temperature was raised to 120°C for 6 days. The reaction was cooled and 3 more equivalents each of ammonium chloride and sodium azide were added. The reaction was again heated for 5 days at 120°C. The reaction was cooled, the inorganic salts filtered, and the filtrate solvent removed in vacuo. Water (200 mL) and ethyl acetate (200 mL) were added to the residue and the layers were separated. The aqueous layer was extracted with ethyl acetate, the organic layers were collected, dried (MgSO4) and the solvent removed in vacuo, to yield a dark yellow oil. The product was purified by flash chromatography in 100% ethyl acetate to 100% ethanol over silica gel to yield 5.60 g of a light yellow 2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1Htetrazol-5-yl)biphenyl-4-yl)methyl]imidazole. Recrystallization from acetonitrile yielded 4.36 g of light yellow crystals which still melted broadly. The crystals were taken up in 100 mL of hot acetonitrile. The solid that did not dissolve was filtered off to yield 1.04 g of product as a light yellow solid, melting point of 2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4- yl)methyl]imidazole 183.5-184.5°C.
2-n-Butyl-4-chloro-5-hydroxymethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4- yl)methyl]imidazole may be converted to potassium salt.

brand name

Cozaar (Merck).

Therapeutic Function

Antihypertensive

General Description

Losartan, 2-butyl-4-chloro-1-[p-(o-1H-tetrazol-5-yl-phenyl)benzyl]imidazole-5-methanol monopotassiumsalt (Cozarr), was the first nonpeptide imidazole to beintroduced as an orally active angiotensin II antagonist withhigh specificity for AT1. When administered to patients, itundergoes extensive first-pass metabolism, with the 5-methanol being oxidized to a carboxylic acid. This metabolismis mediated by CYP 2C9 and 3A4 isozymes. The 5-methanol metabolite is approximately 15 times more potentthan the parent hydroxyl compound. Because the parent hydroxylcompound has affinity for the AT1 receptor, strictlyspeaking, it is not a prodrug.

Flammability and Explosibility

Non flammable

Losartan Preparation Products And Raw materials

Raw materials

1-Methylimidazole Sodium azide Losartan carboxylic acid Methanol solution of sodium methoxide 2-n-Butyl-4-Chloro-5-Hydroxymethyl Imidazole

4′-Methylbiphenyl-2-carboxylic acid methyl ester Thionyl chloride Ammonium hydroxide Potassium hydroxide

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Preparation Products

METHYL TRIPHENYLMETHYL ETHER Losartan potassium

Losartan Suppliers

Global( 281)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12468	58
Sinoway Industrial co., ltd.	0592-5800732; +8613806035118	xie@china-sinoway.com	China	992	58
Ouhuang Engineering Materials (Hubei) Co., Ltd	+8617702722807	admin@hbouhuang.com	China	3001	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21688	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9341	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	+86 18953170293	sales@sdzschem.com	China	2931	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10247	58
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	alice@crovellbio.com	China	8829	58

Supplier	Advantage
Hebei Mojin Biotechnology Co., Ltd	58
Sinoway Industrial co., ltd.	58
Ouhuang Engineering Materials (Hubei) Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
career henan chemical co	58
SHANDONG ZHI SHANG CHEMICAL CO.LTD	58
Shenzhen Nexconn Pharmatechs Ltd	58
Hebei Guanlang Biotechnology Co., Ltd.	58

View Lastest Price from Losartan manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-05-31	Losartan 114798-26-4	US $220.00-85.00 / Kg/Bag	1Kg/Bag	99% up, High Density	20 tons	Sinoway Industrial co., ltd.
2024-04-24	Losartan 114798-26-4	US $5.00 / kg	1kg	99.92%	50000tons	Ouhuang Engineering Materials (Hubei) Co., Ltd
2023-11-27	Losartan 114798-26-4	US $0.00-0.00 / kg	1kg	99%	500kg	Wuhan Senwayer Century Chemical Co.,Ltd

Losartan
114798-26-4
US $220.00-85.00 / Kg/Bag
99% up, High Density
Sinoway Industrial co., ltd.

Losartan
114798-26-4
US $5.00 / kg
99.92%
Ouhuang Engineering Materials (Hubei) Co., Ltd

Losartan
114798-26-4
US $0.00-0.00 / kg
99%
Wuhan Senwayer Century Chemical Co.,Ltd

Losartan Spectrum

Losartan(114798-26-4)¹HNMR

114798-26-4(Losartan)Related Search:

Benzyl nicotinate Benzyl alcohol Benzyl benzoate Nitrotetrazolium blue chloride Methanol

Imidazole 1H-Tetrazole-1-acetic acid Bifendate Benzyl isocyanate Benzyl chloride

2,3,5-Triphenyltetrazolium chloride Tetrazole TRIPHENYL LOSARTAN,Trithyl Losartan,TRITYL LOSARTAN Benzyl Difluorochloromethane

LOSARTAN MONOPOTASSIUM SALT,LOSARTAN POTASSIUM SALT,LOSARTAN POTASSIUM Losartan carboxylic acid 4''-METHYL-2-CYANO-BIPHENYL (FOR LOSARTAN)

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2-Butyl-4-chloro-5-(hydroxymethyl)-1-[(2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole Compound 89 2-n-butyl-4-chloro-5-hydroxyMethyl-1-[(2'-(1H-tetrazole-5-yl)biph 2-Butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)-biphenyl-4-yl]methyl]-1H-imidazol-5-methanol (2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol dup89 nyl)-4-yl)methyl)- 2-butyl-4-chloro-1-[p-(o-1h-tetrazol-5-ylphenyl)benzyl]imidazole-5- methanol LOSARTAN LosartanC22H23C1N60 1h-imidazole-5-methanol, 2-butyl-4-chloro-1-((2'-(1h-tetrazol-5-yl)(1,1'- biphenyl)-4-yl)methyl)- (1-((2-(1H-TETRAZOL-5-YL)BIPHENYL-4-YL)METHYL)-2-BUTYL-4-CHLORO-1H-IMIDAZOL-5-YL)METHANOL (LOSARTAN) 2-Butyl-4-chloro-1-[[2’-(1H-tetrazol-5-y1)[1，1'-biphenyl]’4’y1]methyl]-1H-imidazole-5-methanol 2-Butyl-3-[[2'-(2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl]-5-chloro-3H-imidazole-4-methanol (2-BUTYL-4-CHLORO-1-{[2'-(1H-TETRAZOL-5-YL)-4-BIPHENYLYL]METHYL}-1H-IMIDAZOL-5-YL)METHANOL Losartan (DuP-753) [2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-4-imidazolyl]methanol 1H-Imidazole-5-methanol, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- Losartan Potassium Form-I Losartan USP/EP/BP 2-Butyl-4-chloro-1[[(2'-(1 H-tetrazole-5-yl) (1,1'-biphenyl)-4yl]methyl]-1H imidazole-5-methanol (Losartan) Losartan (DUP 89) LosartanQ: What is Losartan Q: What is the CAS Number of Losartan Q: What is the storage condition of Losartan Q: What are the applications of Losartan LOS Benzaldehyde,3,4-dichloro-6-hydroxy- (3-oxo-1lambda3,2-benziodoxol-5-yl)acetate Losartan（base） 2 butyl 4-chloro-1[(2-(1H-tetrazole-5[1,1 biphenyl]-4-yl]methyl]-H imidazole-5methanol (1-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-butyl-4-chloro-1H-imidazol-5-yl)methanol 114798-26-4 C22H23ClN6O Isotopically Labeled Pharmaceutical Reference Standard