KN-92 (hydrochloride)
- CAS No.
- 1431698-47-3
- Chemical Name:
- KN-92 (hydrochloride)
- Synonyms
- CS-1448;KN92-HCl;KN-92 (hydrochloride);KN 92 HYDROCHLORIDE; KN92 HYDROCHLORIDE;N-(2-(((3-(4-Chlorophenyl)allyl)(methyl)amino)methyl)phenyl)-4-methoxybenzenesulfonamide hydrochloride;Inhibitor,derivative,experimental,inactive,KN-92,KN92 hydrochloride,KN92,inhibit,analog,KN 92 hydrochloride,control,KN 92
- CBNumber:
- CB82591540
- Molecular Formula:
- C24H26Cl2N2O3S
- Molecular Weight:
- 493.44584
- MDL Number:
- MFCD25372041
- MOL File:
- 1431698-47-3.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
KN-92 (hydrochloride) price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 9000890 | KN-92 (hydrochloride) ≥98% | 1431698-47-3 | 1mg | $107 | 2024-03-01 | Buy |
| Cayman Chemical | 9000890 | KN-92 (hydrochloride) ≥98% | 1431698-47-3 | 5mg | $471 | 2024-03-01 | Buy |
| Cayman Chemical | 9000890 | KN-92 (hydrochloride) ≥98% | 1431698-47-3 | 10mg | $836 | 2024-03-01 | Buy |
| Biorbyt Ltd | orb181267 | KN-92-hydrochloride >98% | 1431698-47-3 | 100mg | $986 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181267 | KN-92-hydrochloride >98% | 1431698-47-3 | 250mg | $1802 | 2021-12-16 | Buy |
KN-92 (hydrochloride) Chemical Properties,Uses,Production
Biological Activity
kn-92 is an inactive analog of kn-93. kn-93 is the cam kinase ii inhibitor. [1]hearts were treated with the cam kinase inhibitor kn-93 or the inactive analog kn-92 (0.5 μm) for 10 min before clofilium exposure. early afterdepolarizations (eads) were largely inhibited by kn-93 contrasted to kn-92. there were little differences in parameters favoring eads such as monophasic action potential duration or heart rate in kn-92- or kn-93- treated hearts. cam kinase activity in situ increased 37% in hearts with eads compared to hearts without eads. this increase in cam kinase activity was prevented by pretreatment with kn-93. [1]in vitro, kn-93 potently suppressed rabbit myocardial cam kinase activity (calculated ki ≤ 2.58 μm), but the inactive analog kn-92 did not (ki > 100 μm). the actions of kn-93 and kn-92 on ica and other repolarizing k+currents did not illustrate preferential ead suppression by kn-93. [1]
References
1. kn-93, an inhibitor of multifunctional ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. j pharmacol exp ther. 1998 dec;287(3):996-1006.
KN-92 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 4664 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2784 | 58 |