ChemicalBook >> CAS DataBase List >>Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide
Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide
![Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide Structure](CAS/20150408/GIF/325970-71-6.gif)
- CAS No.
- 325970-71-6
- Chemical Name:
- Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide
- Synonyms
- L67 >=98% (HPLC);DNA LIGASE INHIBITOR; L-67; L 67;Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide
- CBNumber:
- CB82668145
- Molecular Formula:
- C16H14Br2N4O4
- Molecular Weight:
- 486.11
- MDL Number:
- MFCD00363966
- MOL File:
- 325970-71-6.mol
Last updated:2023-05-21 10:59:17
Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide Properties
| storage temp. | Store at -20°C |
|---|---|
| solubility |
DMSO:21.5(Max Conc. mg/mL);44.23(Max Conc. mM) DMF:10.0(Max Conc. mg/mL);20.57(Max Conc. mM) Water:1.0(Max Conc. mg/mL);2.06(Max Conc. mM) |
| form | A crystalline solid |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS07,GHS08,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H361-H372-H410 |
| Precautionary statements | P201-P264-P280-P301+P330+P331-P312 |
Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22941 | L67 ≥98% | 325970-71-6 | 5mg | $97 | 2024-03-01 | Buy |
| Cayman Chemical | 22941 | L67 ≥98% | 325970-71-6 | 10mg | $184 | 2024-03-01 | Buy |
| Cayman Chemical | 22941 | L67 ≥98% | 325970-71-6 | 25mg | $433 | 2024-03-01 | Buy |
| Cayman Chemical | 22941 | L67 ≥98% | 325970-71-6 | 50mg | $721 | 2024-03-01 | Buy |
| ChemScene | CS-5279 | L67 >98.0% | 325970-71-6 | 100mg | $280 | 2021-12-16 | Buy |
Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide Chemical Properties,Uses,Production
Description
L67 is a competitive inhibitor of DNA ligases I and III (IC50s = 10 and 10 μM for human DNA ligase I and human ligase IIIβ). It blocks DNA binding (Ki = 10 μM), increasing the cytotoxicity of DNA-damaging agents. It also inhibits mitochondrial DNA ligase IIIα and induces the production of reactive oxygen species (ROS) and apoptosis in cancerous, but not non-malignant, cells. It does not inhibit DNA ligase IV or T4 DNA ligase at concentrations up to 100 μM.
Uses
L 67 is used in the identification and validation of human DNA ligase inhibitors using computer-aided grug design.
Synthesis of Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide from 3,5-DIBROMO-4-METHYLANILINE
Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide Preparation Products And Raw materials
Global( 38)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| TargetMol Chemicals Inc. | 021-021-33632979 15002134094 | marketing@targetmol.com | China | 7854 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7892 | 56 |
| Nanjing Chalf-Pharm Technology Co., Ltd. | 025-57018978 18251899859 | sales@chalf-pharm.com | China | 5928 | 50 |
Glycine, N-(3,5-dibroMo-4-Methylphenyl)-, 2-[(2-hydroxy-5-nitrophenyl)Methylene]hydrazide
DNA LIGASE INHIBITOR; L-67; L 67
L67 >=98% (HPLC)
325970-71-6
C16H14Br2N4O4