Morinidazole
- CAS No.
- 92478-27-8
- Chemical Name:
- Morinidazole
- Synonyms
- Morinidazole;Morpholinenidazole impurity H;1-(2-methyl-5-nitro-1H-imidazol-1-yl)-3-morpholinopropan-2-ol;4-Morpholineethanol, α-[(2-methyl-5-nitro-1H-imidazol-1-yl)methyl]-;alpha-[(2-Methyl-5-nitro-1H-imidazol-1-yl)methyl]-4-morpholineethanol
- CBNumber:
- CB82716291
- Molecular Formula:
- C11H18N4O4
- Molecular Weight:
- 270.29
- MDL Number:
- MFCD28386297
- MOL File:
- 92478-27-8.mol
| Boiling point | 521.4±50.0 °C(Predicted) |
|---|---|
| Density | 1.44±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO : ≥ 100 mg/mL (369.97 mM) |
| pka | 14.14±0.20(Predicted) |
| FDA UNII | TUPWG40JAL |
Morinidazole price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-5058 | Morinidazole >98.0% | 92478-27-8 | 5mg | $420 | 2021-12-16 | Buy |
| ChemScene | CS-5058 | Morinidazole >98.0% | 92478-27-8 | 10mg | $600 | 2021-12-16 | Buy |
| Crysdot | CD31000234 | Morinidazole 98+% | 92478-27-8 | 5mg | $245 | 2021-12-16 | Buy |
| Crysdot | CD31000234 | Morinidazole 98+% | 92478-27-8 | 10mg | $350 | 2021-12-16 | Buy |
Morinidazole Chemical Properties,Uses,Production
Description
Morinidazole (迈灵达®), discovered and developed by Jiangsu Hansoh Pharmaceutical, was approved by the CFDA in February 2014. Morinidazole is a novel third generation 5-nitroimidazoleclass antimicrobial agent indicated for the treatment of amoebiasis and anaerobic bacterial infections including appendicitis and pelvic inflammatory disease. 5-Nitroimidazole antimicrobial drugs act via nitroreduction of the molecules in the pathogens; as an analog of metronidazole, morinidazole exhibits greater antiparasitic potency against Trichomonas vaginalis and amoebic protozoa, and relatively weaker toxicity in vitro and in preclinical studies compared with metronidazole.
Uses
Morinidazole is a useful research chemical compound used as a microbial drug against Trichomoniasis, a non-viral sexually transmitted disease.
Synthesis
The strategy to prepare morinidazole, which exists as a racemate, overlaps with that of ornidazole. Commercially available epichlorohydrin (176) was reacted with commercial 2-methyl-5-nitro-1H-imidazole (175) to provide ornidazole 177 in 51% yield. Next, epoxide 178 was obtained in 84% through the treatment of ornidazole 177 with TBAF in aqueous sodium hydroxide. Subsequently, the ring of epoxide 178 was opened with the treatment of morpholine (179) to afford morinidazole (XX) in 75% yield.
Morinidazole Preparation Products And Raw materials
Raw materials
Preparation Products
Morinidazole Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| Huadong Medicine (Xi'an)Bodyguard Pharmaceutical Co.,Ltd. | +86-029-86185165 +8618629664246 | guoyuan@eastchinapharm.com | China | 1615 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| FarmaSino Pharmaceuticals (Jiangsu) Co.,Ltd | 025-86979920 18118984557 | txd@farmasino.com | China | 150 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3423 | 58 |
| ChemStrong Scientific Co.,Ltd | 0755-0755-66853366 13670046396 | sales@chem-strong.com | China | 17993 | 56 |