WS6
- CAS No.
- 1421227-53-3
- Chemical Name:
- WS6
- Synonyms
- WS6;CS-1811;WS-6;WS 6;WS6, >=98%;WS6 USP/EP/BP;WS6 >=98% (HPLC);WS6, 1421227-53-3;4-[[6-[(cyclopropylcarbonyl)amino]-4-pyrimidinyl]oxy]-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzeneacetamide;N-(6-{4-[({4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}carbamoyl)methyl]phenoxy}pyrimidin-4-yl)cyclopropanecarboxamide;N-(6-(4-(2-(4-((4-METHYLPIPERAZIN-1-YL)METHYL)-3-(TRIFLUOROMETHYL)PHENYLAMINO)-2-OXOETHYL)PHENOXY)PYRIMIDIN-4-YL)CYCLOPROPANECARBOXAMIDE
- CBNumber:
- CB82723011
- Molecular Formula:
- C29H31F3N6O3
- Molecular Weight:
- 568.59
- MDL Number:
- MFCD26793882
- MOL File:
- 1421227-53-3.mol
- MSDS File:
- SDS
WS6 price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0757 | WS6 ≥98% (HPLC) | 1421227-53-3 | 5mg | $56.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0757 | WS6 ≥98% (HPLC) | 1421227-53-3 | 25mg | $482 | 2022-05-15 | Buy |
| Cayman Chemical | 17672 | WS-6 ≥95% | 1421227-53-3 | 1mg | $26 | 2024-03-01 | Buy |
| Cayman Chemical | 17672 | WS-6 ≥95% | 1421227-53-3 | 5mg | $91 | 2024-03-01 | Buy |
| Cayman Chemical | 17672 | WS-6 ≥95% | 1421227-53-3 | 10mg | $169 | 2024-03-01 | Buy |
WS6 Chemical Properties,Uses,Production
Uses
WS6 is a β-cell proliferation indocer via the IκB kinase pathway and modulation of the Erb3 binding-protein. Potential treatment and cure for diabetes type I.
Biological Activity
ws6 is a small-molecule inducer of β cell proliferation [1].β cells are a subset of cells in the pancreatic islets and play an important role in regulating glucose homeostasis through the production of insulin [1].ws6 is a small-molecule inducer of β cell proliferation. in mouse β cell line r7t1, ws6 induced cell proliferation with ec50 value of 0.28 μm. ws6 was very active in primary human and rodent islets. in primary rat and human β cells, ws6 induced rat β cell proliferation with ec50 value of 0.4 μm and increased 4% of rat β cells and 3% of human β cells to proliferate. in intact islet cultures, ws6 significantly induced proliferation [1]. in cultured human islets, ws6 induced β cell proliferation and also α cell proliferation. however, ws6 didn’t influence the expression of β cell-specific transcription factors and the amount of insulin-positive β cells, which suggested that ws6 didn’t influence β cell differentiation and human islet cell viability [2].in type 1 diabetes (t1d) mice, ws6 significantly reduced blood glucose and increased β cell proliferation from 3.8% to 6.4% [1].
storage
Store at -20°C
References
[1]. shen w, tremblay ms, deshmukh va, et al. small-molecule inducer of β cell proliferation identified by high-throughput screening. j am chem soc, 2013, 135(5): 1669-1672.
[2]. boerner bp, george nm, mir su, et al. ws6 induces both alpha and beta cell proliferation without affecting differentiation or viability. endocr j, 2015, 62(4): 379-386.
WS6 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 28098 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9991 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | sales@aceschem.com | United States | 19639 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
