Atezolizumab
- CAS No.
- 1380723-44-3
- Chemical Name:
- Atezolizumab
- Synonyms
- MPDL3280A;Atezolizumab;Atezolizumab (anti-PD-L1);Research Grade Atezolizumab(DHJ70101);Atezolizumab,Inhibitor,MPDL3280A,inhibit,Apoptosis,Autophagy
- CBNumber:
- CB82744221
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
| storage temp. | Store at -80°C |
|---|---|
| NCI Dictionary of Cancer Terms | atezolizumab |
| FDA UNII | 52CMI0WC3Y |
| NCI Drug Dictionary | atezolizumab |
| ATC code | L01XC32 |
Atezolizumab price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-7490 | Atezolizumab 98.98% | 1380723-44-3 | 1mg | $280 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | ATB0023621 | ATEZOLIZUMAB 95.00% | 1380723-44-3 | 5MG | $450.15 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BA165584 | Atezolizumab | 1380723-44-3 | 1mg | $600 | 2021-12-16 | Buy |
| ChemScene | CS-7490 | Atezolizumab 98.98% | 1380723-44-3 | 5mg | $670 | 2021-12-16 | Buy |
| ChemScene | CS-7490 | Atezolizumab 98.98% | 1380723-44-3 | 25mg | $2550 | 2021-12-16 | Buy |
Atezolizumab Chemical Properties,Uses,Production
Biological Activity
Atezolizumab inhibits proliferation and induces immune independent apoptosis of osteosarcoma cells. The proliferation of HOS and 143B both were inhibited by atezolizumab in a dose-dependent manner. The IC50 values of HOS and 143B were between 10-20 μg/ml. Atezolizumab treatment reduces endotoxin levels and intestinal mucosal permeability as well as decreases ileum histological scores in septic mice. However, atezolizumab treatment increases the expression of tight junction proteins in the ileum during sepsis.
Description
Atezolizumab (MPDL3280A) is a selective humanized monoclonal IgG1 antibody against programmed death ligand 1 (PD-L1), used for cancer research.
Uses
Atezolizumab is an FDA-approved targeted therapy drug. It is a monoclonal antibody that works by binding to PD-L1, a protein on the surface of certain cancer cells, thus preventing the cancer cells from suppressing the immune system. This allows the immune system to attack and kill the cancer cells. Atezolizumab is approved for use alone or with other drugs to treat Alveolar soft part sarcoma, Hepatocellular carcinoma, Melanoma, Non-small cell lung cancer and Small cell lung cancer.
Atezolizumab Preparation Products And Raw materials
Raw materials
Preparation Products
Atezolizumab Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
| HONG KONG IPURE BIOLOGY CO.,LIMITED | 86 18062405514 18062405514 | ada@ipurechemical.com | CHINA | 3465 | 58 |
| Shanghai Minbiotech Co., Ltd. | +8617315815539 | sales@minbiotech.com | CHINA | 129 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | info@afinechem.com | China | 15377 | 58 |
| Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | dominicguo@gk-bio.com | CHINA | 9427 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
| Wuhan Golt Biotech Co., Ltd. | +8615389281203 | maria@goltbiotech.com | China | 980 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |