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GSK-2256098

GSK-2256098 structure

CAS No.: 1224887-10-8

Chemical Name:: GSK-2256098

Synonyms: CS-2424;GTPL7939;GSK-2256099;GSK-2256098;GSK-2256098, GTPL7939;GSK-2256098;GSK 2256098;FAK inhibitor GS2256098;2-(5-chloro-2-(1-isopropyl-3-methyl-1H-pyrazol-5-ylamino)pyridin-4-ylamino)-N-methoxybenzamide;2-[(5-chloro-2-{[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino}-4-pyridinyl)amino]-N(methyloxy)benzamide;Benzamide, 2-[[5-chloro-2-[[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino]-4-pyridinyl]amino]-N-methoxy-

CBNumber:: CB83044319

Molecular Formula:: C20H23ClN6O2

Molecular Weight:: 414.89

MDL Number:: MFCD30502650

MOL File:: 1224887-10-8.mol

Last updated:2023-06-30 15:45:59

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GSK-2256098 Properties

Density	1.32±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:47.33(Max Conc. mg/mL);114.08(Max Conc. mM) DMF:30.0(Max Conc. mg/mL);72.31(Max Conc. mM) Ethanol:56.0(Max Conc. mg/mL);134.98(Max Conc. mM) Ethanol:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.48(Max Conc. mM)
form	A crystalline solid
pka	5.24±0.10(Predicted)
InChI	InChI=1S/C20H23ClN6O2/c1-12(2)27-19(9-13(3)25-27)24-18-10-17(15(21)11-22-18)23-16-8-6-5-7-14(16)20(28)26-29-4/h5-12H,1-4H3,(H,26,28)(H2,22,23,24)
InChIKey	BVAHPPKGOOJSPU-UHFFFAOYSA-N
SMILES	C(NOC)(=O)C1=CC=CC=C1NC1C(Cl)=CN=C(NC2N(C(C)C)N=C(C)C=2)C=1
FDA UNII	R7O0O4110G

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H332-H335

Precautionary statements

P280-P305+P351+P338-P310

NFPA 704

	0
2		0

GSK-2256098 price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	22955	GSK2256098 ≥98%	1224887-10-8	1mg	$34	2024-03-01	Buy
Cayman Chemical	22955	GSK2256098 ≥98%	1224887-10-8	5mg	$133	2024-03-01	Buy
Cayman Chemical	22955	GSK2256098 ≥98%	1224887-10-8	10mg	$231	2024-03-01	Buy
Cayman Chemical	22955	GSK2256098 ≥98%	1224887-10-8	25mg	$412	2024-03-01	Buy
TRC	G797530	GSK2256098	1224887-10-8	2.5mg	$145	2021-12-16	Buy

Product number	Packaging	Price	Buy
22955	1mg	$34	Buy
22955	5mg	$133	Buy
22955	10mg	$231	Buy
22955	25mg	$412	Buy
G797530	2.5mg	$145	Buy

GSK-2256098 Chemical Properties,Uses,Production

Description

GSK2256098 is an inhibitor of focal adhesion kinase (FAK). It is selective for FAK, inhibiting only FAK greater than 50% in a panel of 261 kinases. GSK2256098 inhibits FAK autophosphorylation at tyrosine 397 (Y397) in OVCAR8 ovarian, U87MG glioblastoma, and A549 lung cancer cell lines (IC₅₀s = 15, 8.5, and 12 nM, respectively). It induces apoptosis and increases PARP levels, decreases viability (IC₅₀ = 25 μM), and inhibits colony formation in L3.6P1 cells. GSK2256098 (75 mg/kg per day) also leads to lower tumor weight and fewer metastases in the Ishikawa orthotopic mouse model of uterine cancer.

Uses

GSK 2256098 is FAK inhibitor. It can be used in biological study of molecular pathways: endothelial cell FAK-?A target for cancer treatment.

storage

Store at -20°C

GSK-2256098 Preparation Products And Raw materials

Raw materials

Preparation Products

GSK-2256098 Suppliers

Global( 101)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32686	60
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23556	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9635	58
Shenzhen Shengda Pharma Limited	755-85269922 +8613424394241	sales@shengdapharm.com	CHINA	310	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58

Supplier	Advantage
Wuhan Topule Biopharmaceutical Co., Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
BOC Sciences	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
ANHUI WITOP BIOTECH CO., LTD	58
Finetech Industry Limited	58
Shenzhen Shengda Pharma Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58

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GSK-2256098 2-(5-chloro-2-(1-isopropyl-3-methyl-1H-pyrazol-5-ylamino)pyridin-4-ylamino)-N-methoxybenzamide GTPL7939 Benzamide, 2-[[5-chloro-2-[[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino]-4-pyridinyl]amino]-N-methoxy- 2-[(5-chloro-2-{[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino}-4-pyridinyl)amino]-N(methyloxy)benzamide CS-2424 FAK inhibitor GS2256098 GSK-2256098;GSK 2256098 GSK-2256099 GSK-2256098, GTPL7939 1224887-10-8 Inhibitors APIs