ACE 031
- CAS No.
- Chemical Name:
- ACE 031
- Synonyms
- ACE 031
- CBNumber:
- CB83123133
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
ACE 031 Chemical Properties,Uses,Production
Description
ACE-031 is a fusion protein comprised of the extracellular domain of the human ActRIIB linked to the Fc (hinge CH2 and CH3 domains) portion of the human immunoglobulin G1 (IgG1). ACE-031 binds avidly to myostatin and other negative regulators of muscle mass and inhibits their biological effects by preventing signaling through the endogenous receptor[1].
Side effects
ACE-031, a soluble ACVR2B receptor, was prematurely terminated due to severe adverse effects, including nosebleeds, gum bleeding, telangiectasia, and erythema attributed to cross-inhibition of BMP9 and BMP10, ligands involved in endothelial cell function. In addition, a 43% decrease in serum follicle-stimulating hormone (FSH), whose synthesis is stimulated by activins, was observed in healthy, postmenopausal women who received a single dose (3 mg/kg) of ACE-031, which caused a near-maximal suppression of activin signaling[2].
Research
Ramatercept (ACE-031) is a soluble form of ACVR2B developed by Acceleron Pharma to treat Duchenne Muscular Dystrophy (DMD). Despite encouraging results of both the animal study, in which ACE-031 significantly increased both type 1 and type 2 muscle fiber cross-sectional area in young mice, and phase 1 clinical study in healthy postmenopausal women, in which ACE-031 injection (3 mg/kg) significantly increased total body lean mass and thigh muscle volume, subsequent phase 2 clinical trial in patients with DMD was terminated due to occurrence of non-muscle-related severe adverse events including nosebleed, gum bleeding, telangiectasia, and/or erythema, halting further development of the drug[2].
References
[1] Craig Campbell. “Myostatin inhibitor ACE-031 treatment of ambulatory boys with Duchenne muscular dystrophy: Results of a randomized, placebo-controlled clinical trial.” Muscle & Nerve 55 4 (2017): 458–464.
[2] Joonho Suh, Yun-Sil Lee. “Myostatin Inhibitors: Panacea or Predicament for Musculoskeletal Disorders?” Journal of Bone Metabolism 27 3 (2020): 151–165.
ACE 031 Preparation Products And Raw materials
Raw materials
Preparation Products
ACE 031 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Zhejiang Hangyu API Co., Ltd | +8617531972939 | anna@api-made.com | China | 2944 | 58 |
Hebei Anlijie Biotechnology Co., Ltd | +8619031013551 | ably@aljbio.com | China | 192 | 58 |
Qingdao Xinli Technology Development Co., Ltd. | +8616632313095 | xinlikeji01@qdxlchem.com | China | 59 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12468 | 58 |
Hebei Xinsheng New Material Technology Co., LTD. | +86-16632316109 | xinshengkeji@xsmaterial.com | China | 1099 | 58 |
Shijiazhuang Saixin Technology Co., Ltd. | +86-16632312509 +86-16632315022 | saixinkeji@aliyun.com | China | 90 | 58 |
Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 616 | 58 |
zhuzhou dingcheng meihei comestic co.,ltd | +8618873369619 | dingchengbusiness8@163.com | China | 260 | 58 |
Sigma Audley | +86-18336680971 +86-18126314766 | nova@sh-teruiop.com | China | 525 | 58 |
hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | sales03@chemcn.cn | China | 952 | 58 |
View Lastest Price from ACE 031 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-06-01 | Ace-031 | US $9.90-9.90 / g | 1g | 99% | 1000g | Wuhan Cell Pharmaceutical Co., Ltd | ||
2024-05-31 | ACE-031 | US $150.00-100.00 / box | 1box | 99.9% | 500 box | hebei hongtan Biotechnology Co., Ltd | ||
2024-05-31 | ACE-031 | US $50.00-30.00 / box | 1box | 99.99% | 1000 | hebei hongtan Biotechnology Co., Ltd |