Moxonidine hydrochloride
- CAS No.
- 75438-58-3
- Chemical Name:
- Moxonidine hydrochloride
- Synonyms
- BDF-5895 HCL;MOXONIDINE HCL;Moxoidine hydrochloride;MOXONIDINE HYDROCHLORIDE;MoxonidineHclC9H12C1N50.HC1;Moxonidine hydrochloride USP/EP/BP;4-CHLORO-6-METHOXY-2-METHYL-5-(2-IMIDAZOLIN-2-YL)AMINOPYRIMIDINE HCL;BDF-5895, 4-Chloro-6-methoxy-2-methyl-5-(2-imidazolin-2-yl)aminopyrimidine hydrochloride;4-CHLORO-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-6-METHOXY-2-METHYL-5-PYRIMIDINAMINE HYDROCHLORIDE;6-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-4-methoxy-2-methyl-1H-pyrimidin-2-amine hydrochloride
- CBNumber:
- CB8686233
- Molecular Formula:
- C9H13Cl2N5O
- Molecular Weight:
- 278.14
- MDL Number:
- MFCD06795643
- MOL File:
- 75438-58-3.mol
| Melting point | 189° |
|---|---|
| CAS DataBase Reference | 75438-58-3(CAS DataBase Reference) |
| FDA UNII | 5RYW07SK5E |
Moxonidine hydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | M1559 | Moxonidine hydrochloride ≥98% | 10MG | $143 | 2024-03-01 | Buy | |
| Sigma-Aldrich | M1559 | Moxonidine hydrochloride ≥98% | 25MG | $285 | 2024-03-01 | Buy | |
| Usbiological | 255893 | Moxonidine hydrochloride | 75438-58-3 | 10mg | $403 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb134877 | Moxonidine hydrochloride >99% | 75438-58-3 | 100mg | $510 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb134877 | Moxonidine hydrochloride >99% | 75438-58-3 | 250mg | $606.9 | 2021-12-16 | Buy |
Moxonidine hydrochloride Chemical Properties,Uses,Production
Description
Moxonidine hydrochloride is a centrally acting antihypertensive agent. Mixed I1 imidazoline receptor and α2-adrenergic agonist; displays 40-fold higher affinity for I1 receptors versus α2-adrenoceptors.
Moxonidine is a selective high-affinity imidazoline I1-receptor agonist and a selectively low-affinity α2-adrenoceptor agonist. It exhibits anti-hypertensive properties by reducing blood pressure efficiently. Moxonidine also exhibits spinal analgesic activity through the α2C-adrenoceptor component.
Uses
Moxonidine is a new-generation centrally acting antihypertensive drug approved for the treatment of mild to moderate essential hypertension. It is suggested to be effective in cases where other agents such as thiazides, beta-blockers, ACE inhibitors, and calcium channel blockers are not appropriate or irresponsive. As well, moxonidine has been shown to present blood pressure-independent beneficial effects on insulin resistance syndrome.
Moxonidine hydrochloride is used as antihypertensive agent. It has been reported to produce dose-dependent analgesia in multiple acute pain assays and has been reported to potently inhibit the binding of [3H]-clonidine to VLM (ventrolateral medulla) membranes in a dose-dependent manner with the IC50 value of 53 ± 10nM.
Application
Moxonidine hydrochloride has been used:
as a standard to study its blood-brain barrier (BBB) permeability in porcine brain lipid extract by parallel artificial membrane permeability assay (PAMPA) method.
as a standard to study the chromatographic behavior and lipophilicity by reversed-phase thin-layer chromatography (RP-TLC).
as an imidazoline I1 receptor agonist to study its effects on excitatory inputs in airway vagal preganglionic neuron (AVPN).
Biological Activity
Moxonidine is a selective high-affinity imidazoline I1-receptor agonist and a selectively low-affinity α2-adrenoceptor agonist. It exhibits anti-hypertensive properties by reducing blood pressure efficiently. Moxonidine also exhibits spinal analgesic activity through the α2C-adrenoceptor component.
Moxonidine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Yikanglong Biotechnology Co., Ltd. | 17791478691 | yklbiotech@163.com | CHINA | 296 | 58 |
| Synbest Biotech(Hangzhou) Co., Ltd | 86-571-88737065 | sales@synbestech.com | CHINA | 171 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 9126 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 27945 | 58 |
| AFINE CHEMICALS LIMITED | 0571-85134551 18958018566; | info@afinechem.com | China | 15377 | 58 |
| Xi'an ZB Biotech Co.,Ltd | +8618591943808 | sales01@xazbbio.com | China | 816 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9634 | 58 |
View Lastest Price from Moxonidine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-11-09 | Moxonidine hydrochloride
75438-58-3
|
US $0.00 / Kg/Bag | 1KG | 97.5%-102% HPLC;EP | 10KGS | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2021-08-11 | Moxonidine hydrochloride USP/EP/BP
75438-58-3
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited | |
 |
2020-05-10 | Moxonidine hydrochloride
75438-58-3
|
US $0.00-0.00 / Kg | 1KG | 99.0% | 500 MT | Shaanxi Dideu Medichem Co. Ltd |
-
- Moxonidine hydrochloride
75438-58-3
- US $0.00 / Kg/Bag
- 97.5%-102% HPLC;EP
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Moxonidine hydrochloride USP/EP/BP
75438-58-3
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
-
- Moxonidine hydrochloride
75438-58-3
- US $0.00-0.00 / Kg
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd