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Cyclic AMP

Cyclic AMP structure

CAS No.: 60-92-4

Chemical Name:: Cyclic AMP

Synonyms: CAMP;ADENOSINE CYCLOPHOSPHATE;Acrasin;ADENOSINE CYCLPHOSPHATE;(4aR,6R,7R,7aS)-6-(6-Amino-9H-purin-9-yl)-2,7-dihydroxytetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine 2-oxide;3:5-CAMP;Cyclo-AMP;CYCLIC AMP;3',5'-cAMPH;Adenosine 3'

CBNumber:: CB8747868

Molecular Formula:: C10H12N5O6P

Molecular Weight:: 329.21

MDL Number:: MFCD00005845

MOL File:: 60-92-4.mol

MSDS File:: SDS

Last updated:2024-02-06 18:17:50

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Cyclic AMP Properties

Melting point	260 °C (dec.)(lit.)
alpha	-53.7 º (c=0.7,water)
Boiling point	56.12°C
Density	2.47±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	H₂O: 10 mg/mL pH of aqueous solution is approx. 3.0. The sodium salt (A6885) is about 20×
form	powder
pka	1.00±0.60(Predicted)
color	white
Water Solubility	50 mg/mL
Merck	14,2708
BRN	52645
Stability	Hygroscopic
FDA UNII	E0399OZS9N
NIST Chemistry Reference	Adenosine 3',5'-cyclic monophosphate(60-92-4)
EPA Substance Registry System	Adenosine, cyclic 3',5'-(hydrogen phosphate) (60-92-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Danger

Hazard statements

H314

Precautionary statements

P264b-P280-P301+P330+P331-P304+P340-P305+P351+P338-P310-P363-P403+P233-P501c

Hazard Codes

C,Xi

Risk Statements

34-36/37/38

Safety Statements

22-24/25-45-36/37/39-26-36

WGK Germany

RTECS

AU7357600

10-21

TSCA

Yes

HS Code

29349990

Toxicity

oms-hmn:oth 100 mmol/L JIDEAE 65,52,75

NFPA 704

	0
2		0

Cyclic AMP price More Price(43)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	A9501	Adenosine 3′,5′-cyclic monophosphate ≥98.5% (HPLC), powder	60-92-4	1g	$295	2024-03-01	Buy
Sigma-Aldrich	A9501	Adenosine 3′,5′-cyclic monophosphate ≥98.5% (HPLC), powder	60-92-4	5g	$1120	2024-03-01	Buy
TCI Chemical	A2381	Adenosine 3',5'-Cyclic Monophosphate Hydrate >99.0%(HPLC)	60-92-4	1g	$86	2024-03-01	Buy
TCI Chemical	A2381	Adenosine 3',5'-Cyclic Monophosphate Hydrate >99.0%(HPLC)	60-92-4	5g	$274	2024-03-01	Buy
Alfa Aesar	J60936	Adenosine-3',5'-cyclic monophosphate, 98%	60-92-4	1g	$151	2024-03-01	Buy

Product number	Packaging	Price	Buy
A9501	1g	$295	Buy
A9501	5g	$1120	Buy
A2381	1g	$86	Buy
A2381	5g	$274	Buy
J60936	1g	$151	Buy

Cyclic AMP Chemical Properties,Uses,Production

Chemical Properties

White crystalline or Pale yellow powder; odorless. Slightly soluble in water, almost insoluble in ethanol or ether.

Uses

cAMP is used for intracellular signal transduction in many different organisms, conveying the cAMP-dependent pathway. Restoration of several morphological characteristics of normal fibroblasts in sarcoma cells when treated with adenosine-3': 5'-cyclic monophosphate. In the presence of adenosine 3':5'-cyclic monophosphate, protein kinase I dissociated into two subunits: a subunit binding adenosine 3':5'-cyclic monophosphate, and a catalytic subunit. Stimulation of calcium uptake in platelet membrane vesicles by adenosine 3',5'-cyclic monophosphate.

Definition

ChEBI: Cyclic AMP is a 3',5'-cyclic purine nucleotide having having adenine as the nucleobase. It has a role as a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is an adenyl ribonucleotide and a 3',5'-cyclic purine nucleotide. It is a conjugate acid of a 3',5'-cyclic AMP(1-).

General Description

Cyclic AMP is a second messenger molecule comprised of an adenine ribonucleotide bearing a phosphate group bound to the oxygen molecules at the 3' and 5' positions of the sugar moiety. Cyclic AMP, which is synthesized from ATP by the intracellular enzyme adenylate cyclase, modulates the activity of several hormone-dependent signal transduction pathways.

Biochem/physiol Actions

Naturally-occurring activator of cyclic-AMP-dependent protein kinase (PKA). cAMP is an important second messenger that is linked in many systems to neurotransmitter- or hormone-induced receptor stimulation. The cAMP/PKA signaling pathway has been shown to inhibit cell proliferation, induce differentiation and lead to apoptosis.

Safety Profile

Human mutation data reported.When heated to decomposition it emits toxic fumes ofPOx and NOx.

Synthesis

Cyclic AMP is synthesized from ATP by adenylate cyclase located on the inner side of the plasma membrane and anchored at various locations in the interior of the cell.[1] Adenylate cyclase is activated by a range of signaling molecules through the activation of adenylate cyclase stimulatory G (Gs)-protein-coupled receptors. Adenylate cyclase is inhibited by agonists of adenylate cyclase inhibitory G (Gi)-protein-coupled receptors. Liver adenylate cyclase responds more strongly to glucagon, and muscle adenylate cyclase responds more strongly to adrenaline.
cAMP decomposition into AMP is catalyzed by the enzyme phosphodiesterase.

Cyclic AMP Preparation Products And Raw materials

Raw materials

Moroxydine Dicyclohexylcarbodide or CDCC Styrene cation exchange resin Anhydrous pyridine Water pump

Ammonium bicarbonate Dicyclohexylcarbodiimide

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Preparation Products

6-Thioguanine INOSINE-3',5'-CYCLIC PHOSPHATE

Cyclic AMP Suppliers

Global( 525)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
HangZhou RunYan Pharma Technology Co.,LTD.	+86-88660901 +86-18112526015	sales@runyanpharma.com	China	326	58
Wuhu Nuowei chemistry Co., Ltd.	+86-0553-2911116-802 +undefined17756524438	sales1@nuowei-chem.com	China	1642	58
Hangzhou Meiya Pharmaceutical Co Ltd	+86-021-33686691 +8618001850931	sales@meiyapharm.com	China	57	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12471	58
Hubei Langyou International Trading Co., Ltd	+8618874586545	linda@xrdchem.cn	China	197	58
Yantai Fenglu Fine Chemical Co. LTD	+86-+undefined-008618315825527 +86-+undefined-008618315825527	kevin.wang@xhtechgroup.com	China	42	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	16801	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21689	55
Shanghai Time Chemicals CO., Ltd.	+86-021-57951555 +8617317452075	jack.li@time-chemicals.com	China	1807	55
Nanjing Finetech Chemical Co., Ltd.	025-85710122 17714198479	sales@fine-chemtech.com	CHINA	885	55

Supplier	Advantage
HangZhou RunYan Pharma Technology Co.,LTD.	58
Wuhu Nuowei chemistry Co., Ltd.	58
Hangzhou Meiya Pharmaceutical Co Ltd	58
Hebei Mojin Biotechnology Co., Ltd	58
Hubei Langyou International Trading Co., Ltd	58
Yantai Fenglu Fine Chemical Co. LTD	58
Henan Fengda Chemical Co., Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Time Chemicals CO., Ltd.	55
Nanjing Finetech Chemical Co., Ltd.	55

View Lastest Price from Cyclic AMP manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-03-11	Adenosine 3’,5’-cyclic monophosphate (cAMP) 60-92-4	US $0.00-0.00 / kg	1kg	≥98%	20 MT	Hangzhou Meiya Pharmaceutical Co Ltd
2024-02-22	Cyclic AMP 60-92-4	US $1.00 / kg	1kg	99%	10000kg	Hubei Langyou International Trading Co., Ltd
2024-01-16	Adenosine 3`, 5`-cyclic monophosphate 60-92-4	US $5.00-1.00 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd

Adenosine 3’,5’-cyclic monophosphate (cAMP)
60-92-4
US $0.00-0.00 / kg
≥98%
Hangzhou Meiya Pharmaceutical Co Ltd

Cyclic AMP
60-92-4
US $1.00 / kg
99%
Hubei Langyou International Trading Co., Ltd

Adenosine 3`, 5`-cyclic monophosphate
60-92-4
US $5.00-1.00 / KG
99%
Henan Fengda Chemical Co., Ltd

Cyclic AMP Spectrum

Cyclic AMP(60-92-4)MS Cyclic AMP(60-92-4)¹HNMR Cyclic AMP(60-92-4)IR1 Cyclic AMP(60-92-4)IR2 Cyclic AMP(60-92-4)Raman

60-92-4(Cyclic AMP)Related Search:

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SULPHOSUCCINIC ACID ESTER ADP Adenosine5'-(tetrahydrogen triphosphate), disodiuM salt, trihydrate (9CI) ADENOSINE 5'-TRIPHOSPHATASE Adenosine 5'-monophosphate

Adenosine 3',5'-cyclic monophosphate sodium salt Adenosine-5'-diphosphate disodium salt ADENOSINE 5'-TRIPHOSPHATE DISODIUM SAL& ADENOSINE 5'-DIPHOSPHATE MONOPOTASSIUM SALT Adenosine-5'-diphosphate trilithium salt

ADENOSINE-2':3'-CYCLIC MONOPHOSPHATE, SODIUM SALT 5'-Tosyladenosine ATP disodium salt

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adenosine 3',5'-phosphate monohydrate CAMP, ADENOSINE-3',5'-CYCLIC MONOPHOSPHATE CYCLIC AMP CYCLIC AMP-3',5' 5’-cyclicmonophosphate 6-(6-Amino-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide Adenosine 3',5'-cyclophosphate Adenosine 3',5'-phosphate Adenosine cyclic 3',5'-monophosphate Adenosine cyclic 3',5'-phosphate Adenosine cyclic monophosphate Adenosine, cyclic 3',5'-(hydrogen phosphate) adenosine,cyclic3’,5’-(hydrogenphosphate) adenosine3’,5’-cyclophosphate adenosine3’,5’-phosphate adenosinecyclic3’,5’-phosphate adenosinecyclicmonophosphate adenosinecyclicphosphate,cyclicamp Cyclic 3',5'-adenylic acid Cyclic adenosine 3',5'-monophosphate Cyclic adenosine 3',5'-phosphate cyclic3’,5’-(hydrogenphosphate)-adenosin ADENOSINE 3':5'-CYCLIC MONOPHOSPHATE*HPL C MARKER ADENOSINE 3':5'-CYCLIC MONOPHOSPHATEFREE ACID (-)-ADENOSIN-3',5'-CYCLOPHOSPHORSAEURE 9 Adenosine 3',5'-hydrogen phosphate Adenosine 3'-,5'-cyclic monophosphate, 99+% Adenosine-3’,5’-cyclic phosphoric acid cyclic 3',5'-(hydrogen phosphate)Adenosine Adenosine-3'',5''-monophosphoric acid 3'-5' Cyclic adenosine monophosphate CYCLIC-AMP (ADENOSINE 3'', 5''-CYCLIC MONOPHOSPHATE) ADENOSINE-3,5-CYCLICMONOPHOSPHPRIC ACID extrapure for biochemistry 3μ,5μ-Cyclic AMP, Adenosine 3μ,5μ-cyclophosphate, cAMP Cyclic Adenosine Monophosphate (cAMP) cyclic3’,5’-adenylicacid cyclic3’,5’-amp cyclicadenosine3’,5’-phosphate (S)-CYCLIC 3' 5'-(HYDROGEN PHOSPHATE) ADENOSINE ADENOSINE CYCLICPHOSPHATE (-)-ADENOSINE 3',5'-CYCLIC MONOPHOSPHATE ADENOSINE 3'-,5'-CYCLIC MONOPHOSPHATE ADENOSINE 3':5'-CYCLIC MONOPHOSPHATE ADENOSINE-3',5'-CYCLIC-MONOPHOSPHORIC ACID ADENOSINE-3':5'-CYCLIC MONOPHOSPHORIC ACID ADENOSINE-3':5'-CYCLIC PHOSPHATE ADENOSINE-3',5'-CYCLIC PHOSPHATE H2O ADENOSINE-3',5'-CYCLOPHOSPHORIC ACID ADENOSINE 3'5'-MONOPHOSPHATE ADENOSINE-3':5'-PHOSPHATE CYCLIC 3:5-CAMP 3',5'-CYCLIC AMP 3',5'-Cyclic adenylphosphoric acid Adenosine-3',5'-cyclophosphate ,99% Adenosine 3',5'-Cyclic Monophosphate Hydrate Adenosin Cyclophosphate 3',5'-Cyclic AMP 3',5'-cAMP Adenosine 3',5'-cyclic Monophosphate Monohydrate