AG 1478
- CAS No.
- 175178-82-2
- Chemical Name:
- AG 1478
- Synonyms
- AG 1517;AG 1478;SU 5271;WHI-P 79;NSC 669364;PD-153,035;COMPOUND 32;Tyrphostin AG;AG 1478 USP/EP/BP;TYRPHOSTIN AG 1517
- CBNumber:
- CB8751920
- Molecular Formula:
- C16H14ClN3O2
- Molecular Weight:
- 315.75
- MDL Number:
- MFCD00270914
- MOL File:
- 175178-82-2.mol
- MSDS File:
- SDS
| Melting point | 180 - 183°C |
|---|---|
| storage temp. | 2-8°C |
| solubility | 0.1 M HCl: soluble <0.4 mg/mL |
| form | Pale yellow solid |
| color | Off-white |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| FDA UNII | TC62B68RSL |
AG 1478 price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 658552 | AG 1478 | 175178-82-2 | 5mg | $187 | 2024-03-01 | Buy |
| Sigma-Aldrich | 658548 | InSolution? AG 1478 | 175178-82-2 | 1mg | $113 | 2024-03-01 | Buy |
| Sigma-Aldrich | T4182 | Tyrphostin AG 1478 ≥98% | 175178-82-2 | 1mg | $76.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | T4182 | Tyrphostin AG 1478 ≥98% | 175178-82-2 | 5mg | $228 | 2024-03-01 | Buy |
| American Custom Chemicals Corporation | KIN0001450 | AG 1478 95.00% | 175178-82-2 | 1G | $798 | 2021-12-16 | Buy |
AG 1478 Chemical Properties,Uses,Production
Description
AG-1478 (175478-82-2; base) is a potent and selective inhibitor of the EGFR kinase (IC50 = 3 nM). Inhibits proliferation of a variety human cancer cell lines.1,2 AG-1478 reduces pulmonary fibrosis in a rat model.3?Cell permeable.
Uses
A highly potent and specific EGFR tyrosine kinase inhibitor with an IC50 of 3 nM.
Uses
Tyrphostin AG 1478 is a potent and selective inhibitor of EGFR.
Uses
Tyrphostin AG 1478 has been used as epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor to study its effect on desmoid cell mobility in boyden chamber motility assays. It has also been used to inhibit phosphorylation of c-Met by exogenous transforming growth factor α in epidermoid carcinoma cell line A431.
Definition
ChEBI: Tyrphostin AG 1478 is a member of the class of quinazolines that is quinazoline substituted by methoxy groups at positions 6 and 7 and a (3-chlorophenyl)nitrilo group at position 4. It acts as an epidermal growth factor receptor antagonist. It has a role as an epidermal growth factor receptor antagonist, an antineoplastic agent, a geroprotector and an antiviral agent. It is a member of quinazolines, an aromatic ether and a member of monochlorobenzenes.
General Description
Highly potent and specific inhibitor of the epidermal growth factor (EGF) receptor tyrosine kinase (IC50 = 3 nM). Much higher concentrations are required for inhibition of the kinase activity of the closely related HER2 (neu/erb-B2) receptor (IC50 >100 μM), the platelet-derived growth factor (PDGF) receptor (IC50 >100 μM), and p210Bcr-Abl (IC50 >50 μM). Its mechanism of inhibition likely mimics that of the related compound, 4-(3-chloroanilino)quinazoline (CAQ), a competitive inhibitor with respect to ATP.
Biochem/physiol Actions
Primary TargetEpidermal growth factor receptor kinase
References
1) Han et al. (1996), Tyrphostin AG 1478 preferentially inhibits human glioma cells expressing truncated rather than wild-type epidermal growth factor receptors; Cancer Res., 56 3859 2) Partik et al. (1999), Inhibition of epidermal-growth-factor-receptor-dependent signaling by tyrphostins A25 and AG1478 blocks growth and induces apoptosis in colorectal tumor cells in vitro; J. Cancer Res. Clin. Oncol., 125 379 3) Rice et al. (1999), Specific inhibitors of platelet-derived growth factor or epidermal growth factor receptor tyrosine kinase reduce pulmonary fibrosis in rats; Am. J. Pathol., 155 213
AG 1478 Preparation Products And Raw materials
Raw materials
Preparation Products
AG 1478 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 27644 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shanghai Paulshine Chemical Co., Ltd. | +86-021-37788663 | China | 186 | 64 | |
| Jinan Trio PharmaTech Co., Ltd. | +86 (531) 88811783 | sales@trio-pharmatech.com (International market) | China | 1856 | 62 |
| Spectrum Chemical Manufacturing Corp. | 021-021-021-67601398-809-809-809 15221380277 | marketing_china@spectrumchemical.com | China | 9664 | 60 |
| UHN Shanghai Research & Development Co., Ltd. | 021-58958002 18930822973 | SALES@UHNSHANGHAI.COM | China | 977 | 58 |