[7S-(7alpha,7bbeta,10abeta)]-N-(5,6,7,7b,8,10a-hexahydro-1,2,3,9-tetramethoxy-8-oxobenzo[a]cyclopenta[3,4]cyclobuta[1,2-c]cyclohepten-7-yl)acetamide
- CAS No.
- 6901-13-9
- Chemical Name:
- [7S-(7alpha,7bbeta,10abeta)]-N-(5,6,7,7b,8,10a-hexahydro-1,2,3,9-tetramethoxy-8-oxobenzo[a]cyclopenta[3,4]cyclobuta[1,2-c]cyclohepten-7-yl)acetamide
- Synonyms
- β-Lumi(-)-Colchicine;Colchicine EP Impurity C;N-[(7S,7bR,10aS)-1,2,3,9-Tetrametho;Colchicine Impurity 3(Colchicine EP Impurity C);N-[(7S)-5,6,7,7bβ,8,10aβ-Hexahydro-1,2,3,9-tetramethoxy-8-oxobenzo[a]cyclopenta[3,4]cyclobuta[1,2-c]cyclohepten-7-yl]acetamide;N-((7S,7bR,10aS)-1,2,3,9-tetramethoxy-8-oxo-5,6,7,7b,8,10a-hexahydrobenzo[a]cyclopenta[3,4]cyclobuta[1,2-c][7]annulen-7-yl)acetamide;N-[(7S,7bR,10aS)-5,6,7,7b,8,10a-Hexahydro-1,2,3,9-tetraMethoxy-8-oxobenzo[a]cyclopenta[3,4]cyclobuta[1,2-c]cyclohepten-7-yl]acetaMide;Acetamide, N-[(7S,7bR,10aS)-5,6,7,7b,8,10a-hexahydro-1,2,3,9-tetramethoxy-8-oxobenzo[a]cyclopenta[3,4]cyclobuta[1,2-c]cyclohepten-7-yl]-;[7S-(7alpha,7bbeta,10abeta)]-N-(5,6,7,7b,8,10a-hexahydro-1,2,3,9-tetramethoxy-8-oxobenzo[a]cyclopenta[3,4]cyclobuta[1,2-c]cyclohepten-7-yl)acetamide;[7S-(7alpha,7bbeta,10abeta)]-N-(5,6,7,7b,8,10a-hexahydro-1,2,3,9-tetramethoxy-8-oxobenzo[a]cyclopenta[3,4]cyclobuta[1,2-c]cyclohepten-7-yl)acetamide
- CBNumber:
- CB8895398
- Molecular Formula:
- C22H25NO6
- Molecular Weight:
- 399.437
- MDL Number:
- MFCD00151111
- MOL File:
- 6901-13-9.mol
- MSDS File:
- SDS
[7S-(7alpha,7bbeta,10abeta)]-N-(5,6,7,7b,8,10a-hexahydro-1,2,3,9-tetramethoxy-8-oxobenzo[a]cyclopenta[3,4]cyclobuta[1,2-c]cyclohepten-7-yl)acetamide Properties
Melting point | 177-180°C |
---|---|
Density | 1.30±0.1 g/cm3 (20 ºC 760 Torr) |
storage temp. | Amber Vial, -20°C Freezer, Under Inert Atmosphere |
solubility | Chloroform (Slightly), Methanol (Sparingly) |
form | Solid |
color | Off-White to Pale Orange |
Stability | Light Sensitive |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302 |
Precautionary statements | P264-P270-P301+P312-P330-P501 |
[7S-(7alpha,7bbeta,10abeta)]-N-(5,6,7,7b,8,10a-hexahydro-1,2,3,9-tetramethoxy-8-oxobenzo[a]cyclopenta[3,4]cyclobuta[1,2-c]cyclohepten-7-yl)acetamide price
[7S-(7alpha,7bbeta,10abeta)]-N-(5,6,7,7b,8,10a-hexahydro-1,2,3,9-tetramethoxy-8-oxobenzo[a]cyclopenta[3,4]cyclobuta[1,2-c]cyclohepten-7-yl)acetamide Chemical Properties,Uses,Production
Description
This alkaloid has been isolated from a number of plants including Colchicum kesselringii, C. luteum Baker, Merendera jolanta E. Czerniak, M. raddeana Rgl.and M. robusta Bge. It forms colourless crystals from CHC13-Et20. It is possible that this base may be an artifact formed during the isolation process.
Chemical Properties
Pale Yellow Solid
Uses
An analog of Colchicine (C640000), β-lumicolchicine, does not bind tubulin or disrupt microtubules. A GABAA receptor chloride channel.
Definition
ChEBI: LSM-4236 is a carbotricyclic compound, a member of acetamides and an alkaloid.
References
Santavy, Collect. Czech. Chem. Commun., 16,665 (1951)
Santavy, Pharm. Zent., 96, 307 (1957)
Yusupov, Sadykov, Tr. Nauch. Tashkent. Gos. Univ., 203, 3, 15 (1962)
YUSUpOY, SadykoY, J. Gen. Chem. USSR, 34, 1672 (1964)
Yusupov, Sadykov, Tr. Nauch. Tashkent. Gos. Univ., 286,11,56 (1966)
Chommedov, Yusupov, Sadykov, Khim. Prir. Soedin., 6, 82, 275 (1970)
Trozyan, Yusupov, Sadykov, ibid, 7,541 (1971)
Santavy, Tr. Nauchi. Tashkent, 11 (1972)
[7S-(7alpha,7bbeta,10abeta)]-N-(5,6,7,7b,8,10a-hexahydro-1,2,3,9-tetramethoxy-8-oxobenzo[a]cyclopenta[3,4]cyclobuta[1,2-c]cyclohepten-7-yl)acetamide Preparation Products And Raw materials
Raw materials
Preparation Products
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