ChemicalBook >> CAS DataBase List >>[22R,(+)]-15α-Acetyloxy-5,6β-epoxy-4β,14β,22-trihydroxy-1-oxo-5β-ergosta-2,24-diene-26-oic acid 26,22-lactone

[22R,(+)]-15α-Acetyloxy-5,6β-epoxy-4β,14β,22-trihydroxy-1-oxo-5β-ergosta-2,24-diene-26-oic acid 26,22-lactone

[22R,(+)]-15α-Acetyloxy-5,6β-epoxy-4β,14β,22-trihydroxy-1-oxo-5β-ergosta-2,24-diene-26-oic acid 26,22-lactone structure

CAS No.: 100217-92-3

Chemical Name:: [22R,(+)]-15α-Acetyloxy-5,6β-epoxy-4β,14β,22-trihydroxy-1-oxo-5β-ergosta-2,24-diene-26-oic acid 26,22-lactone

Synonyms: NSC368674;NSC-368674;NSC 368674;Physapubenolide;(+)-Physapubenolide;[22R,(+)]-15α-Acetyloxy-5,6β-epoxy-4β,14β,22-trihydroxy-1-oxo-5β-ergosta-2,24-diene-26-oic acid 26,22-lactone

CBNumber:: CB92372090

Molecular Formula:: C30H40O8

Molecular Weight:: 528.6338

MDL Number:

MOL File:: 100217-92-3.mol

Last updated:2023-03-31 09:12:58

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[22R,(+)]-15α-Acetyloxy-5,6β-epoxy-4β,14β,22-trihydroxy-1-oxo-5β-ergosta-2,24-diene-26-oic acid 26,22-lactone Chemical Properties,Uses,Production

Description

Physapubenolide is natural cytotoxic withanolide antitumor agent, inducing apoptosis by decreasing mitochondrial membrane potential and elevating the Bax/Bcl-2 protein expression ratio. Downregulation of TIGAR sensitizes the antitumor effect of physapubenolide through increasing intracellular ROS levels to trigger apoptosis and autophagosome formation in human breast carcinoma cells. Metabonomics applied in exploring the antitumour mechanism of physapubenolide on hepatocellular carcinoma cells by targeting glycolysis through the Akt-p53 pathway.

[22R,(+)]-15α-Acetyloxy-5,6β-epoxy-4β,14β,22-trihydroxy-1-oxo-5β-ergosta-2,24-diene-26-oic acid 26,22-lactone Preparation Products And Raw materials

Raw materials

Preparation Products

[22R,(+)]-15α-Acetyloxy-5,6β-epoxy-4β,14β,22-trihydroxy-1-oxo-5β-ergosta-2,24-diene-26-oic acid 26,22-lactone Suppliers

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(+)-Physapubenolide [22R,(+)]-15α-Acetyloxy-5,6β-epoxy-4β,14β,22-trihydroxy-1-oxo-5β-ergosta-2,24-diene-26-oic acid 26,22-lactone Physapubenolide NSC 368674 NSC368674 NSC-368674 100217-92-3