(2-METHOXY-5-[2-(2,4,6-TRIMETHOXY-PHENYL)-ETHENESULFONYLMETHYL]-PHENYLAMINO)-ACETIC ACID, SODIUM SALT
![(2-METHOXY-5-[2-(2,4,6-TRIMETHOXY-PHENYL)-ETHENESULFONYLMETHYL]-PHENYLAMINO)-ACETIC ACID, SODIUM SALT Structure](CAS/GIF/592542-59-1.gif)
- CAS No.
- 592542-59-1
- Chemical Name:
- (2-METHOXY-5-[2-(2,4,6-TRIMETHOXY-PHENYL)-ETHENESULFONYLMETHYL]-PHENYLAMINO)-ACETIC ACID, SODIUM SALT
- Synonyms
- CS-1407;Rigosertib;Rigosertib(acid);rigosertib(PI3K/Plk1 inhibitor)ORPHAN DRUG;3: PN: WO2006074149 PAGE: 45 claiMed sequence;(E)-2-((2-Methoxy-5-(((2,4,6-triMethoxystyryl)sulfonyl)Methyl)phenyl)aMino)acetic acid;N-[2-Methoxy-5-[[[(1E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]glycine;Glycine, N-[2-Methoxy-5-[[[(1E)-2-(2,4,6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]phenyl]-;(2-METHOXY-5-[2-(2,4,6-TRIMETHOXY-PHENYL)-ETHENESULFONYLMETHYL]-PHENYLAMINO)-ACETIC ACID, SODIUM SALT;PI3K,Polo-like Kinase (PLK),Rigosertib,Phosphoinositide 3-kinase,Apoptosis,ON 01910,Inhibitor,inhibit,ON01910
- CBNumber:
- CB92457038
- Molecular Formula:
- C21H25NO8S
- Molecular Weight:
- 451.49
- MDL Number:
- MFCD09038489
- MOL File:
- 592542-59-1.mol
- MSDS File:
- SDS
(2-METHOXY-5-[2-(2,4,6-TRIMETHOXY-PHENYL)-ETHENESULFONYLMETHYL]-PHENYLAMINO)-ACETIC ACID, SODIUM SALT Properties
| Melting point | 172-174 °C(Solv: acetone (67-64-1)) |
|---|---|
| Boiling point | 756.1±60.0 °C(Predicted) |
| Density | 1.332±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C,unstable in solution, ready to use. |
| solubility | Soluble in DMSO |
| form | Powder |
| pka | 4.23±0.20(Predicted) |
| FDA UNII | 67DOW7F9GL |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
(2-METHOXY-5-[2-(2,4,6-TRIMETHOXY-PHENYL)-ETHENESULFONYLMETHYL]-PHENYLAMINO)-ACETIC ACID, SODIUM SALT price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | R590713 | Rigosertib | 592542-59-1 | 50mg | $685 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181113 | Rigosertib >98% | 592542-59-1 | 100mg | $765 | 2021-12-16 | Buy |
| ChemScene | CS-1710 | Rigosertib 98.81% | 592542-59-1 | 100mg | $900 | 2021-12-16 | Buy |
| ApexBio Technology | B1288 | Rigosertib | 592542-59-1 | 50mg | $900 | 2021-12-16 | Buy |
| Activate Scientific | AS59462 | Rigosertib 95+% | 592542-59-1 | 1g | $903 | 2021-12-16 | Buy |
(2-METHOXY-5-[2-(2,4,6-TRIMETHOXY-PHENYL)-ETHENESULFONYLMETHYL]-PHENYLAMINO)-ACETIC ACID, SODIUM SALT Chemical Properties,Uses,Production
Uses
Rigosertib is a microtubule destabilizing agent which may be employed in the treatment of high-?risk myelodysplastic syndrome.
Definition
ChEBI: Rigosertib is an N-[2-methoxy-5-({[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl}methyl)phenyl]glycine in which the double bond has E-configuration. It is a non-ATP-competitive inhibitor of PLK1 with an IC50 of 9 nM and exhibits anti-cancer properties. It has a role as a microtubule-destabilising agent, an EC 2.7.11.21 (polo kinase) inhibitor, an apoptosis inducer and an antineoplastic agent. It is a conjugate acid of a rigosertib(1-).
Biological Activity
rigosertib is a dual inhibitor of phosphoinositide 3-kinase (pi3k) and polo-like kinase 1 (plk1) [1].
in vitro
studies show that rigosertib inhibits the pi3k/akt pathway, down-regulates cyclin d1, induces noxa and bim and activates the jnk pathway in human leukemic cells. rigosertib induces apoptosis of a variety of human tumor cell lines including breast, prostate, ovarian, pancreatic, sclc, colorectal, melanoma and et al. for instant, it shows anti-tumor efficacy in bt20, mcf-7, bt474, ov-car-3, a549 and hct-116 with ic50 values of 80nm, 75nm, 50nm, 75nm, 90nm and 75nm, respectively. in addition, rigosertib is also effective against the drug resistant tumor cell lines. it potently inhibits tumor growth with ic50 values of 100nm and 50nm against mes-sa/dx5 and cem/c2, respectively. moreover, it is reported that rigosertib can affect the cell cycle of both normal cells and tumor cells. rigosertib leads to a blockade of cell cycle progression in the g1 and g2/m phases in normal diploid human fetal lung cells. when treated with du145 cells, rigosertib induces cell cycle arrest in g2/m phase [2].
References
[1] anderson r t, keysar s b, bowles d w, et al. the dual pathway inhibitor rigosertib is effective in direct patient tumor xenografts of head and neck squamous cell carcinomas. molecular cancer therapeutics, 2013, 12(10): 1994-2005.
[2] reddy m v r, venkatapuram p, mallireddigari m r, et al. discovery of a clinical stage multi-kinase inhibitor sodium (e)-2-{2-methoxy-5-[(2′, 4′, 6′-trimethoxystyrylsulfonyl) methyl] phenylamino} acetate (on 01910. na): synthesis, structure–activity relationship, and biological activity. journal of medicinal chemistry, 2011, 54(18): 6254-6276.
(2-METHOXY-5-[2-(2,4,6-TRIMETHOXY-PHENYL)-ETHENESULFONYLMETHYL]-PHENYLAMINO)-ACETIC ACID, SODIUM SALT Preparation Products And Raw materials
Raw materials
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Preparation Products
(2-METHOXY-5-[2-(2,4,6-TRIMETHOXY-PHENYL)-ETHENESULFONYLMETHYL]-PHENYLAMINO)-ACETIC ACID, SODIUM SALT Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com | China | 19949 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323967 +86-18015559028 | sales1@artkmedchem.com | China | 39009 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Liaocheng Jinge Synthetic Material CO.,LTD. | 0635-2121866 18365825121 | y18365825121@163.com | China | 109 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
| WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. | 17702719238 17702719238 | sales@sun-shinechem.com | China | 918 | 64 |
| Shanghai Witofly Chemical Co.,Ltd | sales@witofly.com | China | 2867 | 52 |