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Dabigatran Etexilate Mesylate

Dabigatran Etexilate Mesylate Structure
Dabigatran Etexilate Mesylate structure
CAS No.
872728-81-9
Chemical Name:
Dabigatran Etexilate Mesylate
Synonyms
Pradaxa;Pradaxa Mesylate;Dabigatran mesylate;Dabigatran Etexilate Mesylate API;Ethyl 3-(2-(((4-(N-((hexyloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-;Hexyl 2-(4-(((5-((3-ethoxy-3-oxopropyl)(pyridin-2-yl)carbaMoyl)-1-Methyl-1H-benzo[d]iMidazol-2-yl)Methyl)aMino)benzylidene)hydrazinecarboxylate Methanesulfonate;(E)-hexyl 2-(4-((5-((3-ethoxy-3-oxopropyl)(pyridin-2-yl)carbaMoyl)-1-Methyl-1H-benzo[d]iMidazol-2-yl)MethylaMino)benzylidene)hydrazinecarboxylate Methanesulfonate;ethyl 3-(2-(((4-(N-((hexyloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate methanesulfonate;N-[[2-[[[4-[[[(Hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester monomethanesulfonat;Dabig
CBNumber:
CB92500679
Molecular Formula:
C35H45N7O8S
Molecular Weight:
723.85
MDL Number:
MFCD17215180
MOL File:
872728-81-9.mol
MSDS File:
SDS
Last updated:2024-05-13 18:00:15
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Dabigatran Etexilate Mesylate Properties

Melting point >125°C
storage temp. Refrigerator
solubility DMSO (Slightly, Heated), Methanol (Slightly)
form Solid
color White to Pale Yellow
FDA UNII SC7NUW5IIT
NCI Drug Dictionary dabigatran etexilate mesylate

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
Signal word  Danger
Hazard statements  H413
NFPA 704
0
2 0

Dabigatran Etexilate Mesylate price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 007470 Dabigatran Etexilate Mesylate 872728-81-9 10mg $425 2021-12-16 Buy
ApexBio Technology A3345 Dabigatranetexilatemesylate 872728-81-9 100mg $523 2021-12-16 Buy
Biosynth Carbosynth FD20773 Dabigatran etexilate mesylate 872728-81-9 2g $340 2021-12-16 Buy
ApexBio Technology A3345 Dabigatranetexilatemesylate 872728-81-9 50mg $361 2021-12-16 Buy
Biosynth Carbosynth FD20773 Dabigatran etexilate mesylate 872728-81-9 100mg $65 2021-12-16 Buy
Product number Packaging Price Buy
007470 10mg $425 Buy
A3345 100mg $523 Buy
FD20773 2g $340 Buy
A3345 50mg $361 Buy
FD20773 100mg $65 Buy

Dabigatran Etexilate Mesylate Chemical Properties,Uses,Production

Description

Dabigatran etexilate mesylate is a clinical direct thrombin inhibitor and a new type of oral anticoagulant. It can inhibit the formation of thrombus by reversibly and potently competing with the fibrin-specific binding site of thrombin to block fibrin generation.

Chemical Properties

Off-White to Pale Yellow Solid

Uses

Nonpeptide, direct thrombin inhibitor. Antithrombotic.

Clinical Use

Dabigatran Etexilate Mesylate is a direct thrombin inhibitor indicated to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation.

Definition

ChEBI: A methanesulfonate salt obtained by reaction of dabigatran etexilate with one equivalent of dabigatran etexilate. A prodrug for dabigatran, a thrombin inhibitor and anticoagulant which is used for the prevention of stroke and systemic embolism.

Biological Activity

Dabigatran etexilate mesylate (BIBR 1048MS) is an orally active prodrug of Dabigatran. Dabigatran etexilate mesylate has anticoagulant properties and can prevent venous thromboembolism and stroke due to atrial fibrillation.

Mechanism of action

Dabigatran etexilate mesylate is a prodrug of dabigatran that is metabolized in the body and converted to the active dabigatran. Compared with warfarin, dabigatran etexilate mesylate does not require frequent monitoring of coagulation function and dose adjustment during treatment, and there are fewer interactions between drugs and is not affected by eating, thus improving patients' medication compliance.

Side effects

The most common adverse reactions to Dabigatran Etexilate Mesylate (150 mg) were bleeding and gastrointestinal events (i.e. dyspepsia, nausea, epigastric pain, gastrointestinal bleeding, and diarrhoea). Very few patients experienced drug hypersensitivity (including urticaria, rash and pruritus), anaphylactic oedema, anaphylactic reactions and anaphylaxis.

in vivo

Dabigatran etexilate mesylate (BIBR 1048MS; oral; 10, 20 and 50 mg/kg for rats and 1, 2.5 and 5 mg/kg for monkeys) has dose- and time-dependent anticoagulant effects and has maximum effects between 30 and 120 min after administration, respectively.Dabigatran etexilate mesylate maximally and significantly prolongs partial thromboplastin time (aPTT) to 25.2, 38.4 and 78.3 s in 30 min after 10, 20 and 50 mg/kg oral doses, respectively.Dabigatran etexilate mesylate maximally prolongs the aPTT to 34.3 s, 44.0 s, and 63.0 s, respectively, 2h after 1, 2.5 or 5 mg/kg doses in the monkey.

Dabigatran Etexilate Mesylate synthesis

211915-06-9
75-75-2
872728-81-9
Synthesis of Dabigatran Etexilate Mesylate from Dabigatran etexilate and Methanesulfonic acid

Dabigatran Etexilate Mesylate Preparation Products And Raw materials

Raw materials

Dabigatran etexilate Methanesulfonic acid

Preparation Products

Dabigatran Etexilate Mesylate Suppliers

Global( 452)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Mojin Biotechnology Co., Ltd 		+8613288715578 sales@hbmojin.com China 12468 58
shandong perfect biotechnology co.ltd 		+86-53169958659; +8618596095638 sales@sdperfect.com China 294 58
Anhui Ruihan Technology Co., Ltd 		+8617756083858 daisy@anhuiruihan.com China 994 58
Hebei Weimiao Import and Export Trade Co., Ltd. 		+undefined19948166995 sale01@hbweimiao.com China 73 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 18219 58
hebei hongtan Biotechnology Co., Ltd 		+86-86-1913198-3935 +8617331935328 sales03@chemcn.cn China 952 58
Hebei Saisier Technology Co., LTD 		+86-18400010335 +86-18034520335 admin@hbsaisier.cn China 940 58
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 15956 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1811 55
Supplier Advantage
Hebei Mojin Biotechnology Co., Ltd 		58
shandong perfect biotechnology co.ltd 		58
Anhui Ruihan Technology Co., Ltd 		58
Hebei Weimiao Import and Export Trade Co., Ltd. 		58
Henan Fengda Chemical Co., Ltd 		58
hebei hongtan Biotechnology Co., Ltd 		58
Hebei Saisier Technology Co., LTD 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55

View Lastest Price from Dabigatran Etexilate Mesylate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Dabigatran Etexilate Mesylate pictures 2024-05-31 Dabigatran Etexilate Mesylate
872728-81-9
 US $30.00 / kg 1kg 99% 2000kg hebei hongtan Biotechnology Co., Ltd
Dabigatran Etexilate Mesylate pictures 2024-05-10 Dabigatran Etexilate Mesylate
872728-81-9
 US $6.00 / KG 1KG More than 99% 2000KG/Month Hebei Saisier Technology Co., LTD
Dabigatran Etexilate Mesylate pictures 2024-04-27 Dabigatran Etexilate Mesylate
872728-81-9
 US $10.00-3.00 / KG 1KG 99% g-kg-tons, free sample is available Henan Fengda Chemical Co., Ltd

Dabigatran Etexilate Mesylate Spectrum

Dabigatran Etexilate Mesylate(872728-81-9)1HNMR

872728-81-9(Dabigatran Etexilate Mesylate)Related Search:

5-(2-Bromoethyl)-2,3-dihydrobenzofuran 3-(S)-(+)-(1-Carbamoyl-1,1-diphenylmethyl)pyrroloidine-L-(+)-tartarate Dabigatran Etexilate iMpurity 4 Dabigatran Etexilate iMpurity 3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester
N-(4-CYANO-PHENYL)-GLYCINE Chloroacetic anhydride 4-Aminobenzamidine dihydrochloride 3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMINO]-PROPIONIC ACID ETHYL ESTER HEXYL CHLOROFORMATE
N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-(2-pyridinyl)-beta-alanine ethyl ester hydrochloride Dabigatran Etexilate iMpurity D Dabigatran iMpurity E Des-(N-2-pyridyl-β-alanine Ethyl Ester) Dabigatran Etexilate 5-Ethyl Carboxylate (Dabigatran IMpurity) Dabigatran iMpurity F
Dabigatran etexilate Dabigatran

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Dabigatran etexilate mesylate (Z)-ethyl 3-(2-(((4-(N'-((hexyloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate methanesulfonate Dabigatran etexilate mesylate,Pradaxa Dabigatran etexilate Mesylate 872728-81-9 [[[(Hexyloxy)carbonyl]aMino]iMinoMethyl]phenyl]aMino]Methyl]-1-Methyl-1H-benziMidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanineethylesterMonoMethanesulfonat N-[[2-[[[4-[[[(Hexyloxy)carbonyl]aMino]iMinoMethyl]phenyl]aMino]Methyl]-1-Methyl-1H-benziMidazol-5-y BIBR 1048MS N-[[2-[[[4-[[[(Hexyloxy)carbonyl]aMino]iMinoMethyl]phenyl]aMino]Methyl]-1-Methyl-1H-benziMidazol-5-yl]carbonyl]-N-2-pyridinyl-β-alanine Ethyl Ester Methanesulfonate Dabigatran etexilate Methanesulfonate PRADAXA; BIBR 1048MS; DABIGATRAN ETEXILATE METHANESULFONATE ate MesyL atran EtexiL Dabig Dabigatran EtexiL Dabigatran Etexilate Mesylate USP/EP/BP Dabigatran Etexilate Mesylate Pellet Dabigatran Etexilate Mesylate- IH B-Alanine, N-[[2-[[[4-[[[(hexyloxy) carbonyl] amino] iminomethyl] phenyl] amino] methyl]-1-methyl-1H-benzimidazol-5-yl] carbonyl]-N-2-pyridinyl -,ethyl ester, methanesulfonate N-[[2-[[[4-[[[(Hexyloxy)carbonyl] amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-β-alanine ethyl ester methanesulfonate Dabigatran Etexilate MesylateQ: What is Dabigatran Etexilate Mesylate Q: What is the CAS Number of Dabigatran Etexilate Mesylate Q: What is the storage condition of Dabigatran Etexilate Mesylate Q: What are the applications of Dabigatran Etexilate Mesylate Dabigatran Mesylate Reference N-[[2-[[[4-[[[(Hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester monomethanesulfonat supplier in Chin CS-900 3-([2-[[(4-(N-n-hexyloxycarbonylcarbamimidoyl)-phenylamino)-methyl]]-1-methyl-1H-benzimidazole-5-carbonyl]-pyridin-2-yl-amino)ethyl propionate mesylate Ethyl 3-(2-(((4-(N-((hexyloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin- N-[[2-[[[4-[[[(Hexyloxy)carbonyl]amino]iminomethyl]phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester monomethanesulfonat Pradaxa Hexyl 2-(4-(((5-((3-ethoxy-3-oxopropyl)(pyridin-2-yl)carbaMoyl)-1-Methyl-1H-benzo[d]iMidazol-2-yl)Methyl)aMino)benzylidene)hydrazinecarboxylate Methanesulfonate (E)-hexyl 2-(4-((5-((3-ethoxy-3-oxopropyl)(pyridin-2-yl)carbaMoyl)-1-Methyl-1H-benzo[d]iMidazol-2-yl)MethylaMino)benzylidene)hydrazinecarboxylate Methanesulfonate Pradaxa Mesylate Dabigatran Etexilate Mesylate API ethyl 3-(2-(((4-(N-((hexyloxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate methanesulfonate Dabigatran mesylate Dabigatran etexilatemesi Pradaxa, Dabigatran etexilate mesylate 872728-81-9 C34H41N7O5CH4O3S C35H45N7O8S Aromatics Bases & Related Reagents Heterocycles Intermediates & Fine Chemicals Nucleotides Pharmaceuticals Dabigatran etexilate mesylate API 872728-81-9