ChemicalBook >> CAS DataBase List >>Y16
Y16
- CAS No.
- 429653-73-6
- Chemical Name:
- Y16
- Synonyms
- Y16;Y16, >98%;Y16, 429653-73-6;Inhibitor,inhibit,Y-16,Y 16,Ras,Y16;4-(3-((3-Methylbenzyl)oxy)benzylidene)-1-phenylpyrazolidine-3,5-dione;4-[[3-[(3-Methylphenyl)methoxy]phenyl]methylene]-1-phenyl-3,5-pyrazolidinedione;3,5-Pyrazolidinedione, 4-[[3-[(3-methylphenyl)methoxy]phenyl]methylene]-1-phenyl-
- CBNumber:
- CB92735545
- Molecular Formula:
- C24H20N2O3
- Molecular Weight:
- 384.43
- MDL Number:
- MFCD03083787
- MOL File:
- 429653-73-6.mol
Last updated:2023-05-18 11:31:09
Y16 price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0873 | Y16 ≥98% (HPLC) | 429653-73-6 | 25mg | $42.8 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0873 | Y16 ≥98% (HPLC) | 429653-73-6 | 5mg | $118 | 2024-03-01 | Buy |
| ChemScene | CS-3879 | Y16 99.03% | 429653-73-6 | 10mg | $144 | 2021-12-16 | Buy |
| ChemScene | CS-3879 | Y16 99.03% | 429653-73-6 | 5mg | $84 | 2021-12-16 | Buy |
| Crysdot | CD31001921 | Y16 98+% | 429653-73-6 | 5mg | $49 | 2021-12-16 | Buy |
Y16 Chemical Properties,Uses,Production
Biological Activity
Y16 is an inhibitor of G protein-coupled Rho GEFs. It blocks the binding of LARG and Rho with a Kd of 80 nM.
in vitro
Y16 (10-30 μΜ; 24 hours; NIH 3T3 cells) could inhibit RhoA-GTP formation induced by serum dose dependently and is specific for RhoA.
Y16 (10-30 μΜ; 24 hours ; NIH 3T3 cells) efficiently inhibits serum or SDF-1α-induced phospho-MLC and phospho-FAK formation, which are downstream of RhoA.
Cell Viability Assay
| Cell Line: | NIH 3T3 cells |
| Concentration: | 10 μΜ, 30 μΜ |
| Incubation Time: | 24 hours |
| Result: | Inhibited RhoA-GTP formation induced by serum dose dependently and was specific for RhoA. |
Western Blot Analysis
| Cell Line: | NIH 3T3 cells |
| Concentration: | 10 μΜ, 30 μΜ |
| Incubation Time: | 24 hours |
| Result: | Inhibited serum or SDF-1α-induced phospho-MLC and phospho-FAK formation, which were downstream of RhoA. |
target
| Target | Value | ||||
| RhoGEFs () |
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| Shanghai JiYi Biotechnology Co. Ltd. | 13621943973 | sales@shjiyipharmatech.com | China | 1166 | 55 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
429653-73-6(Y16)Related Search:
Y16
4-[[3-[(3-Methylphenyl)methoxy]phenyl]methylene]-1-phenyl-3,5-pyrazolidinedione
Y16, 429653-73-6
Y16, >98%
3,5-Pyrazolidinedione, 4-[[3-[(3-methylphenyl)methoxy]phenyl]methylene]-1-phenyl-
Inhibitor,inhibit,Y-16,Y 16,Ras,Y16
4-(3-((3-Methylbenzyl)oxy)benzylidene)-1-phenylpyrazolidine-3,5-dione
429653-73-6