N-Methylhydroxylamine hydrochloride
- CAS No.
- 4229-44-1
- Chemical Name:
- N-Methylhydroxylamine hydrochloride
- Synonyms
- 42229-44-1;N-Methylhydroxylamin;N-METHYLHYDROXYAMINEHCL;N-METHYLHYDROXYLAMINE HCL;Methyl hydroxylamine .HCL;Methylhydroxylammonium chloride;N-Methylhydroxyaminehydrochloride;N-METHYLHYDROXYLAMMONIUM CHLORIDE;n-hydroxy-methanaminhydrochloride;N-Hydroxymethanamine hydrochloride
- CBNumber:
- CB9403590
- Molecular Formula:
- CH6ClNO
- Molecular Weight:
- 83.52
- MDL Number:
- MFCD00012597
- MOL File:
- 4229-44-1.mol
- MSDS File:
- SDS
| Melting point | 86-88 °C(lit.) |
|---|---|
| Density | 1.36 g/cm3 |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | H2O: 0.1 g/mL, clear, very faintly yellow |
| form | solid |
| color | white |
| Water Solubility | soluble |
| Sensitive | Hygroscopic |
| BRN | 3541409 |
| CAS DataBase Reference | 4229-44-1(CAS DataBase Reference) |
| FDA UNII | MGW04SJ1LZ |
| EPA Substance Registry System | Methanamine, N-hydroxy-, hydrochloride (4229-44-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-24/25 | |||||||||
| RIDADR | 1759 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 3-10 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29280090 | |||||||||
| NFPA 704 |
|
N-Methylhydroxylamine hydrochloride price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | M50400 | N-Methylhydroxylamine hydrochloride 98% | 4229-44-1 | 5g | $63.5 | 2024-03-01 | Buy |
| Sigma-Aldrich | M50400 | N-Methylhydroxylamine hydrochloride 98% | 4229-44-1 | 10g | $102 | 2024-03-01 | Buy |
| TCI Chemical | M0804 | N-Methylhydroxylamine Hydrochloride >97.0%(T) | 4229-44-1 | 5g | $32 | 2024-03-01 | Buy |
| TCI Chemical | M0804 | N-Methylhydroxylamine Hydrochloride >97.0%(T) | 4229-44-1 | 25g | $125 | 2024-03-01 | Buy |
| Alfa Aesar | L02202 | N-Methylhydroxylamine hydrochloride, 98% | 4229-44-1 | 5g | $64.65 | 2024-03-01 | Buy |
N-Methylhydroxylamine hydrochloride Chemical Properties,Uses,Production
Chemical Properties
The substance appears as white to almost white crystals or crystalline powder. It exhibits solubility in water.
Uses
N-Methylhydroxylamine hydrochloride is used as an inorganic catalyst used in the transamidation of primary amides with amines. It is employed in constructing hydroxamates, important functional groups for the complexation of iron.
Preparation
N-methylhydroxylamine hydrochloride (N-MHA) was synthesized by a high pressure catalytic hydrogenation method using noble metal Pd/C and Pt-Rh/C as the catalyst. During the synthesis process, the catalyst was easily poisoned and the products would be deeply reduced to methylamine. Therefore, the purity of N-MHA is low and the cost is high. An industrial electrolytic cell was designed for the electrochemical synthesis of N-methylhydroxylamine hydrochloride (N-MHA). Copper was used as the cathode, graphite as the anode, and a cation membrane as the separator. The results show that N-MHA with a high purity of 99% can be electrosynthesized directly from nitromethane in HCl solution.
Reactions
N-methylhydroxylamine hydrochloride was widely used in the 1,3-dipolar cycloaddition and N-methylation reaction. For example, it has been considered an extremely important intermediate in the synthesis of biological active azetidinone and isoxazole compounds such as piperylone, isopyrine, and muscimole.
References
[1] A. Gibson and S. Mirzazadeh. N-methylhydroxylamine inhibits and M&B 22948 potentiates relaxations of the mouse anococcygeus to non-adrenergic, non-cholinergic field stimulation and to nitrovasodilator drugs.British Journal of Pharmacology.1989, 96 637-644. DOI:10.1111/j.1476-5381.1989.tb11863.x
[2] J. R. Ochoa Gomez. Electrosynthesis of N-methylhydroxylamine.Journal of Applied Electrochemistry.1991, 21 331-334. DOI:10.1007/BF01020218
[3] Reacts with aldehydes and ketones to give nitrones, which undergo 1,3-dipolar addition reactions with alkenes. Cycloaddition to trimethylvinylsilane has been used in a 2-carbon extension of aldehydes to ɑ?-unsaturated aldehydes: J. Org. Chem., 49, 3421 (1984). DOI:10.1021/jo00192a047
[4] Intramolecular cycloaddition has been used as a route to bicyclic systems, e.g. from citronellal: Org. Synth. Coll., 6, 670 (1988).
[5] Reviews: 1,3-Dipolar cycloadditions of nitrones: Synthesis, 205 (1975). The [3+2] nitrone-olefin cycloaddition reaction: Org. React., 36, 1 (1988). Synthetic applications of nitrones: Org. Prep. Proced. Int., 17, 25 (1985).
[6] For conversion to, and reactions of, the N,O-bis(TMS) derivative, see: J. Chem. Soc., Perkin 1, 1823 (1989).
[7] GAN Y, WENKUI Z, HUANG H, et al. Industrial Synthesis of N-Methylhydroxylamine Hydrochloride by Electrochemical Reduction of Nitromethane[J]. Chinese Journal of Chemical Engineering, 2006, 14: 649-653. DOI:10.1016/S1004-9541(06)60129-8.
N-Methylhydroxylamine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 | info@accelachem.com | United States | 19965 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 | 1015@dideu.com | China | 2263 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9641 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | marketing1@neostarunited.com | China | 8348 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 12733 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
View Lastest Price from N-Methylhydroxylamine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-03-11 | N-Methylhydroxylamine hydrochloride
4229-44-1
|
US $55.00 / kg | 1kg | 99% | 5000 tons | Hebei Duling International Trade Co. LTD | |
 |
2022-10-14 | N-Methylhydroxylamine hydrochloride
4229-44-1
|
US $0.00-0.00 / KG | 1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2021-11-15 | N-Methylhydroxylamine hydrochloride
4229-44-1
|
US $7.00 / g | 100g | 99% | 500ton/Month | Qiuxian Baitai New Material Co., LTD |
-
- N-Methylhydroxylamine hydrochloride
4229-44-1
- US $55.00 / kg
- 99%
- Hebei Duling International Trade Co. LTD
-
- N-Methylhydroxylamine hydrochloride
4229-44-1
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- N-Methylhydroxylamine hydrochloride
4229-44-1
- US $7.00 / g
- 99%
- Qiuxian Baitai New Material Co., LTD